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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PAPPA
Full Name:
Pappalysin-1
Alias:
Insulin-like growth factor-dependent IGF-binding protein 4 protease;Pregnancy-associated plasma protein A
Type:
Mass (Da):
180973
Number AA:
1627
UniProt ID:
Q13219
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S58
A
A
R
G
R
R
A
S
P
P
P
P
P
P
P
Site 2
T87
Q
R
E
A
R
G
A
T
E
E
P
S
P
P
S
Site 3
S91
R
G
A
T
E
E
P
S
P
P
S
R
A
L
Y
Site 4
S94
T
E
E
P
S
P
P
S
R
A
L
Y
F
S
G
Site 5
Y98
S
P
P
S
R
A
L
Y
F
S
G
R
G
E
Q
Site 6
S100
P
S
R
A
L
Y
F
S
G
R
G
E
Q
L
R
Site 7
T120
E
L
P
R
D
A
F
T
L
Q
V
W
L
R
A
Site 8
S133
R
A
E
G
G
Q
R
S
P
A
V
I
T
G
L
Site 9
S145
T
G
L
Y
D
K
C
S
Y
I
S
R
D
R
G
Site 10
Y146
G
L
Y
D
K
C
S
Y
I
S
R
D
R
G
W
Site 11
Y170
Q
D
N
K
D
P
R
Y
F
F
S
L
K
T
D
Site 12
T176
R
Y
F
F
S
L
K
T
D
R
A
R
Q
V
T
Site 13
T183
T
D
R
A
R
Q
V
T
T
I
N
A
H
R
S
Site 14
Y191
T
I
N
A
H
R
S
Y
L
P
G
Q
W
V
Y
Site 15
Y211
D
G
Q
F
M
K
L
Y
V
N
G
A
Q
V
A
Site 16
S220
N
G
A
Q
V
A
T
S
G
E
Q
V
G
G
I
Site 17
S229
E
Q
V
G
G
I
F
S
P
L
T
Q
K
C
K
Site 18
S243
K
V
L
M
L
G
G
S
A
L
N
H
N
Y
R
Site 19
Y249
G
S
A
L
N
H
N
Y
R
G
Y
I
E
H
F
Site 20
Y252
L
N
H
N
Y
R
G
Y
I
E
H
F
S
L
W
Site 21
T264
S
L
W
K
V
A
R
T
Q
R
E
I
L
S
D
Site 22
S270
R
T
Q
R
E
I
L
S
D
M
E
T
H
G
A
Site 23
T274
E
I
L
S
D
M
E
T
H
G
A
H
T
A
L
Site 24
S298
D
N
V
K
H
A
W
S
P
M
K
D
G
S
S
Site 25
S304
W
S
P
M
K
D
G
S
S
P
K
V
E
F
S
Site 26
S305
S
P
M
K
D
G
S
S
P
K
V
E
F
S
N
Site 27
S311
S
S
P
K
V
E
F
S
N
A
H
G
F
L
L
Site 28
T330
E
P
P
L
C
G
Q
T
L
C
D
N
T
E
V
Site 29
T335
G
Q
T
L
C
D
N
T
E
V
I
A
S
Y
N
Site 30
S340
D
N
T
E
V
I
A
S
Y
N
Q
L
S
S
F
Site 31
Y341
N
T
E
V
I
A
S
Y
N
Q
L
S
S
F
R
Site 32
S345
I
A
S
Y
N
Q
L
S
S
F
R
Q
P
K
V
Site 33
S346
A
S
Y
N
Q
L
S
S
F
R
Q
P
K
V
V
Site 34
Y355
R
Q
P
K
V
V
R
Y
R
V
V
N
L
Y
E
Site 35
Y361
R
Y
R
V
V
N
L
Y
E
D
D
H
K
N
P
Site 36
T369
E
D
D
H
K
N
P
T
V
T
R
E
Q
V
D
Site 37
S401
E
L
D
V
L
E
V
S
N
S
S
L
R
R
R
Site 38
S403
D
V
L
E
V
S
N
S
S
L
R
R
R
L
I
Site 39
T431
C
D
P
E
C
N
H
T
L
T
G
H
D
G
G
Site 40
T433
P
E
C
N
H
T
L
T
G
H
D
G
G
D
C
Site 41
S490
Q
T
C
F
D
P
D
S
P
H
R
A
Y
L
D
Site 42
Y495
P
D
S
P
H
R
A
Y
L
D
V
N
E
L
K
Site 43
S520
L
N
I
F
F
A
K
S
S
E
E
E
L
A
G
Site 44
S521
N
I
F
F
A
K
S
S
E
E
E
L
A
G
V
Site 45
Y551
I
V
L
N
P
S
F
Y
G
M
P
G
H
T
H
Site 46
S578
Y
H
V
F
R
G
I
S
E
I
Q
S
C
S
D
Site 47
S582
R
G
I
S
E
I
Q
S
C
S
D
P
C
M
E
Site 48
S584
I
S
E
I
Q
S
C
S
D
P
C
M
E
T
E
Site 49
S593
P
C
M
E
T
E
P
S
F
E
T
G
D
L
C
Site 50
T603
T
G
D
L
C
N
D
T
N
P
A
P
K
H
K
Site 51
S611
N
P
A
P
K
H
K
S
C
G
D
P
G
P
G
Site 52
T644
S
Y
A
D
D
D
C
T
D
S
F
T
P
N
Q
Site 53
S646
A
D
D
D
C
T
D
S
F
T
P
N
Q
V
A
Site 54
T648
D
D
C
T
D
S
F
T
P
N
Q
V
A
R
M
Site 55
Y663
H
C
Y
L
D
L
V
Y
Q
G
W
Q
P
S
R
Site 56
S669
V
Y
Q
G
W
Q
P
S
R
K
P
A
P
V
A
Site 57
T686
P
Q
V
L
G
H
T
T
D
S
V
T
L
E
W
Site 58
T690
G
H
T
T
D
S
V
T
L
E
W
F
P
P
I
Site 59
Y722
E
G
R
I
L
V
Q
Y
A
S
N
A
S
S
P
Site 60
S724
R
I
L
V
Q
Y
A
S
N
A
S
S
P
M
P
Site 61
S728
Q
Y
A
S
N
A
S
S
P
M
P
C
S
P
S
Site 62
S733
A
S
S
P
M
P
C
S
P
S
G
H
W
S
P
Site 63
S735
S
P
M
P
C
S
P
S
G
H
W
S
P
R
E
Site 64
S739
C
S
P
S
G
H
W
S
P
R
E
A
E
G
H
Site 65
S755
D
V
E
Q
P
C
K
S
S
V
R
T
W
S
P
Site 66
S756
V
E
Q
P
C
K
S
S
V
R
T
W
S
P
N
Site 67
T759
P
C
K
S
S
V
R
T
W
S
P
N
S
A
V
Site 68
S761
K
S
S
V
R
T
W
S
P
N
S
A
V
N
P
Site 69
S764
V
R
T
W
S
P
N
S
A
V
N
P
H
T
V
Site 70
T770
N
S
A
V
N
P
H
T
V
P
P
A
C
P
E
Site 71
S809
F
V
S
T
D
W
D
S
S
G
A
V
N
D
I
Site 72
Y886
L
Q
C
K
P
L
K
Y
K
V
V
R
D
P
P
Site 73
S900
P
L
Q
M
D
V
A
S
I
L
H
L
N
R
K
Site 74
S917
D
M
D
L
N
L
G
S
V
Y
Q
Y
W
V
I
Site 75
S927
Q
Y
W
V
I
T
I
S
G
T
E
E
S
E
P
Site 76
S935
G
T
E
E
S
E
P
S
P
A
V
T
Y
I
H
Site 77
T939
S
E
P
S
P
A
V
T
Y
I
H
G
S
G
Y
Site 78
Y940
E
P
S
P
A
V
T
Y
I
H
G
S
G
Y
C
Site 79
Y946
T
Y
I
H
G
S
G
Y
C
G
D
G
I
I
Q
Site 80
Y991
I
D
E
P
S
R
C
Y
F
H
D
G
D
G
V
Site 81
S1007
E
E
F
E
Q
K
T
S
I
K
D
C
G
V
Y
Site 82
Y1014
S
I
K
D
C
G
V
Y
T
P
Q
G
F
L
D
Site 83
T1015
I
K
D
C
G
V
Y
T
P
Q
G
F
L
D
Q
Site 84
S1025
G
F
L
D
Q
W
A
S
N
A
S
V
S
H
Q
Site 85
S1028
D
Q
W
A
S
N
A
S
V
S
H
Q
D
Q
Q
Site 86
S1059
R
T
K
V
I
D
L
S
E
G
I
S
Q
H
A
Site 87
S1077
C
T
I
S
Y
P
Y
S
Q
L
A
Q
T
T
F
Site 88
T1108
V
H
L
V
T
D
G
T
Y
Y
G
D
Q
K
Q
Site 89
Y1109
H
L
V
T
D
G
T
Y
Y
G
D
Q
K
Q
E
Site 90
T1117
Y
G
D
Q
K
Q
E
T
I
S
V
Q
L
L
D
Site 91
T1125
I
S
V
Q
L
L
D
T
K
D
Q
S
H
D
L
Site 92
S1129
L
L
D
T
K
D
Q
S
H
D
L
G
L
H
V
Site 93
S1153
I
P
V
V
H
D
L
S
Q
P
F
Y
H
S
Q
Site 94
Y1157
H
D
L
S
Q
P
F
Y
H
S
Q
A
V
R
V
Site 95
S1159
L
S
Q
P
F
Y
H
S
Q
A
V
R
V
S
F
Site 96
T1188
F
D
N
F
D
P
V
T
L
S
S
C
Q
R
G
Site 97
S1190
N
F
D
P
V
T
L
S
S
C
Q
R
G
E
T
Site 98
S1191
F
D
P
V
T
L
S
S
C
Q
R
G
E
T
Y
Site 99
T1197
S
S
C
Q
R
G
E
T
Y
S
P
A
E
Q
S
Site 100
S1199
C
Q
R
G
E
T
Y
S
P
A
E
Q
S
C
V
Site 101
S1224
E
L
A
V
E
N
A
S
L
N
C
S
S
S
D
Site 102
S1228
E
N
A
S
L
N
C
S
S
S
D
R
Y
H
G
Site 103
S1230
A
S
L
N
C
S
S
S
D
R
Y
H
G
A
Q
Site 104
Y1233
N
C
S
S
S
D
R
Y
H
G
A
Q
C
T
V
Site 105
T1239
R
Y
H
G
A
Q
C
T
V
S
C
R
T
G
Y
Site 106
Y1246
T
V
S
C
R
T
G
Y
V
L
Q
I
R
R
D
Site 107
S1259
R
D
D
E
L
I
K
S
Q
T
G
P
S
V
T
Site 108
T1268
T
G
P
S
V
T
V
T
C
T
E
G
K
W
N
Site 109
Y1294
I
P
D
H
H
Q
V
Y
A
A
S
F
S
C
P
Site 110
S1297
H
H
Q
V
Y
A
A
S
F
S
C
P
E
G
T
Site 111
T1304
S
F
S
C
P
E
G
T
T
F
G
S
Q
C
S
Site 112
T1305
F
S
C
P
E
G
T
T
F
G
S
Q
C
S
F
Site 113
S1308
P
E
G
T
T
F
G
S
Q
C
S
F
Q
C
R
Site 114
S1325
A
Q
L
K
G
N
N
S
L
L
T
C
M
E
D
Site 115
T1359
V
P
N
A
D
L
Q
T
A
R
C
R
E
N
K
Site 116
Y1375
K
V
G
S
F
C
K
Y
K
C
K
P
G
Y
H
Site 117
Y1381
K
Y
K
C
K
P
G
Y
H
V
P
G
S
S
R
Site 118
S1386
P
G
Y
H
V
P
G
S
S
R
K
S
K
K
R
Site 119
S1390
V
P
G
S
S
R
K
S
K
K
R
A
F
K
T
Site 120
T1397
S
K
K
R
A
F
K
T
Q
C
T
Q
D
G
S
Site 121
T1400
R
A
F
K
T
Q
C
T
Q
D
G
S
W
Q
E
Site 122
T1414
E
G
A
C
V
P
V
T
C
D
P
P
P
P
K
Site 123
Y1426
P
P
K
F
H
G
L
Y
Q
C
T
N
G
F
Q
Site 124
S1445
C
R
I
K
C
E
D
S
D
A
S
Q
G
L
G
Site 125
S1448
K
C
E
D
S
D
A
S
Q
G
L
G
S
N
V
Site 126
S1479
Q
E
M
Q
G
Q
C
S
V
P
N
E
L
N
S
Site 127
Y1496
K
L
Q
C
P
D
G
Y
A
I
G
S
E
C
A
Site 128
T1504
A
I
G
S
E
C
A
T
S
C
L
D
H
N
S
Site 129
S1505
I
G
S
E
C
A
T
S
C
L
D
H
N
S
E
Site 130
S1511
T
S
C
L
D
H
N
S
E
S
I
I
L
P
M
Site 131
Y1566
E
P
F
M
G
D
N
Y
C
D
A
I
N
N
R
Site 132
T1585
Y
D
G
G
D
C
C
T
S
T
V
K
T
K
K
Site 133
S1586
D
G
G
D
C
C
T
S
T
V
K
T
K
K
V
Site 134
T1587
G
G
D
C
C
T
S
T
V
K
T
K
K
V
T
Site 135
T1590
C
C
T
S
T
V
K
T
K
K
V
T
P
F
P
Site 136
T1594
T
V
K
T
K
K
V
T
P
F
P
M
S
C
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation