KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
GRIN2B
Full Name:
Glutamate [NMDA] receptor subunit epsilon-2
Alias:
Glutamate [NMDA] receptor subunit epsilon 2 precursor; Glutamate receptor, ionotropic, N-methyl D-aspartate 2B; HNR3; NMDAR2B; NMDE2; NME2; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3; NR2B; NR3
Type:
Channel, ligand-gated; Channel, calcium
Mass (Da):
166367
Number AA:
1484
UniProt ID:
Q13224
International Prot ID:
IPI00297933
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0017146
GO:0030054
GO:0045211
Uniprot
OncoNet
Molecular Function:
GO:0004972
GO:0005509
GO:0005234
PhosphoSite+
KinaseNET
Biological Process:
GO:0045471
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
K
P
R
A
E
C
C
S
P
K
F
W
L
V
L
Site 2
S24
A
V
L
A
V
S
G
S
R
A
R
S
Q
K
S
Site 3
S28
V
S
G
S
R
A
R
S
Q
K
S
P
P
S
I
Site 4
S31
S
R
A
R
S
Q
K
S
P
P
S
I
G
I
A
Site 5
S63
K
D
D
F
H
H
L
S
V
V
P
R
V
E
L
Site 6
S90
T
R
I
C
D
L
M
S
D
R
K
I
Q
G
V
Site 7
T103
G
V
V
F
A
D
D
T
D
Q
E
A
I
A
Q
Site 8
S141
M
A
D
K
D
E
S
S
M
F
F
Q
F
G
P
Site 9
S155
P
S
I
E
Q
Q
A
S
V
M
L
N
I
M
E
Site 10
Y179
V
T
T
Y
F
P
G
Y
Q
D
F
V
N
K
I
Site 11
S188
D
F
V
N
K
I
R
S
T
I
E
N
S
F
V
Site 12
T189
F
V
N
K
I
R
S
T
I
E
N
S
F
V
G
Site 13
S193
I
R
S
T
I
E
N
S
F
V
G
W
E
L
E
Site 14
S208
E
V
L
L
L
D
M
S
L
D
D
G
D
S
K
Site 15
S214
M
S
L
D
D
G
D
S
K
I
Q
N
Q
L
K
Site 16
Y239
C
T
K
E
E
A
T
Y
I
F
E
V
A
N
S
Site 17
S279
E
F
P
T
G
L
I
S
V
S
Y
D
E
W
D
Site 18
S281
P
T
G
L
I
S
V
S
Y
D
E
W
D
Y
G
Site 19
Y282
T
G
L
I
S
V
S
Y
D
E
W
D
Y
G
L
Site 20
Y287
V
S
Y
D
E
W
D
Y
G
L
P
A
R
V
R
Site 21
S309
T
A
A
S
D
M
L
S
E
H
S
F
I
P
E
Site 22
S312
S
D
M
L
S
E
H
S
F
I
P
E
P
K
S
Site 23
S319
S
F
I
P
E
P
K
S
S
C
Y
N
T
H
E
Site 24
S320
F
I
P
E
P
K
S
S
C
Y
N
T
H
E
K
Site 25
T324
P
K
S
S
C
Y
N
T
H
E
K
R
I
Y
Q
Site 26
Y330
N
T
H
E
K
R
I
Y
Q
S
N
M
L
N
R
Site 27
Y338
Q
S
N
M
L
N
R
Y
L
I
N
V
T
F
E
Site 28
T343
N
R
Y
L
I
N
V
T
F
E
G
R
N
L
S
Site 29
S350
T
F
E
G
R
N
L
S
F
S
E
D
G
Y
Q
Site 30
S352
E
G
R
N
L
S
F
S
E
D
G
Y
Q
M
H
Site 31
Y356
L
S
F
S
E
D
G
Y
Q
M
H
P
K
L
V
Site 32
S407
E
Q
E
D
D
H
L
S
I
V
T
L
E
E
A
Site 33
S426
V
E
S
V
D
P
L
S
G
T
C
M
R
N
T
Site 34
T442
P
C
Q
K
R
I
V
T
E
N
K
T
D
E
E
Site 35
T446
R
I
V
T
E
N
K
T
D
E
E
P
G
Y
I
Site 36
Y452
K
T
D
E
E
P
G
Y
I
K
K
C
C
K
G
Site 37
S471
I
L
K
K
I
S
K
S
V
K
F
T
Y
D
L
Site 38
T475
I
S
K
S
V
K
F
T
Y
D
L
Y
L
V
T
Site 39
Y479
V
K
F
T
Y
D
L
Y
L
V
T
N
G
K
H
Site 40
T493
H
G
K
K
I
N
G
T
W
N
G
M
I
G
E
Site 41
T514
Y
M
A
V
G
S
L
T
I
N
E
E
R
S
E
Site 42
S541
I
S
V
M
V
S
R
S
N
G
T
V
S
P
S
Site 43
S546
S
R
S
N
G
T
V
S
P
S
A
F
L
E
P
Site 44
S548
S
N
G
T
V
S
P
S
A
F
L
E
P
F
S
Site 45
Y585
E
Y
F
S
P
V
G
Y
N
R
C
L
A
D
G
Site 46
S599
G
R
E
P
G
G
P
S
F
T
I
G
K
A
I
Site 47
S678
F
Q
R
P
N
D
F
S
P
P
F
R
F
G
T
Site 48
T685
S
P
P
F
R
F
G
T
V
P
N
G
S
T
E
Site 49
S690
F
G
T
V
P
N
G
S
T
E
R
N
I
R
N
Site 50
Y699
E
R
N
I
R
N
N
Y
A
E
M
H
A
Y
M
Site 51
Y705
N
Y
A
E
M
H
A
Y
M
G
K
F
N
Q
R
Site 52
S720
G
V
D
D
A
L
L
S
L
K
T
G
K
L
D
Site 53
S770
G
I
A
I
Q
K
D
S
G
W
K
R
Q
V
D
Site 54
S811
E
K
N
E
V
M
S
S
Q
L
D
I
D
N
M
Site 55
S882
V
A
I
E
E
R
Q
S
V
M
N
S
P
T
A
Site 56
S886
E
R
Q
S
V
M
N
S
P
T
A
T
M
N
N
Site 57
T890
V
M
N
S
P
T
A
T
M
N
N
T
H
S
N
Site 58
T894
P
T
A
T
M
N
N
T
H
S
N
I
L
R
L
Site 59
S912
A
K
N
M
A
N
L
S
G
V
N
G
S
P
Q
Site 60
S917
N
L
S
G
V
N
G
S
P
Q
S
A
L
D
F
Site 61
S920
G
V
N
G
S
P
Q
S
A
L
D
F
I
R
R
Site 62
S929
L
D
F
I
R
R
E
S
S
V
Y
D
I
S
E
Site 63
S930
D
F
I
R
R
E
S
S
V
Y
D
I
S
E
H
Site 64
Y932
I
R
R
E
S
S
V
Y
D
I
S
E
H
R
R
Site 65
S935
E
S
S
V
Y
D
I
S
E
H
R
R
S
F
T
Site 66
S940
D
I
S
E
H
R
R
S
F
T
H
S
D
C
K
Site 67
T942
S
E
H
R
R
S
F
T
H
S
D
C
K
S
Y
Site 68
S944
H
R
R
S
F
T
H
S
D
C
K
S
Y
N
N
Site 69
Y949
T
H
S
D
C
K
S
Y
N
N
P
P
C
E
E
Site 70
S960
P
C
E
E
N
L
F
S
D
Y
I
S
E
V
E
Site 71
Y962
E
E
N
L
F
S
D
Y
I
S
E
V
E
R
T
Site 72
S964
N
L
F
S
D
Y
I
S
E
V
E
R
T
F
G
Site 73
T969
Y
I
S
E
V
E
R
T
F
G
N
L
Q
L
K
Site 74
Y981
Q
L
K
D
S
N
V
Y
Q
D
H
Y
H
H
H
Site 75
S993
H
H
H
H
R
P
H
S
I
G
S
A
S
S
I
Site 76
S996
H
R
P
H
S
I
G
S
A
S
S
I
D
G
L
Site 77
S998
P
H
S
I
G
S
A
S
S
I
D
G
L
Y
D
Site 78
S999
H
S
I
G
S
A
S
S
I
D
G
L
Y
D
C
Site 79
Y1004
A
S
S
I
D
G
L
Y
D
C
D
N
P
P
F
Site 80
T1012
D
C
D
N
P
P
F
T
T
Q
S
R
S
I
S
Site 81
T1013
C
D
N
P
P
F
T
T
Q
S
R
S
I
S
K
Site 82
S1015
N
P
P
F
T
T
Q
S
R
S
I
S
K
K
P
Site 83
S1017
P
F
T
T
Q
S
R
S
I
S
K
K
P
L
D
Site 84
S1019
T
T
Q
S
R
S
I
S
K
K
P
L
D
I
G
Site 85
S1029
P
L
D
I
G
L
P
S
S
K
H
S
Q
L
S
Site 86
S1030
L
D
I
G
L
P
S
S
K
H
S
Q
L
S
D
Site 87
S1033
G
L
P
S
S
K
H
S
Q
L
S
D
L
Y
G
Site 88
S1036
S
S
K
H
S
Q
L
S
D
L
Y
G
K
F
S
Site 89
Y1039
H
S
Q
L
S
D
L
Y
G
K
F
S
F
K
S
Site 90
S1043
S
D
L
Y
G
K
F
S
F
K
S
D
R
Y
S
Site 91
S1046
Y
G
K
F
S
F
K
S
D
R
Y
S
G
H
D
Site 92
Y1049
F
S
F
K
S
D
R
Y
S
G
H
D
D
L
I
Site 93
S1050
S
F
K
S
D
R
Y
S
G
H
D
D
L
I
R
Site 94
S1058
G
H
D
D
L
I
R
S
D
V
S
D
I
S
T
Site 95
S1061
D
L
I
R
S
D
V
S
D
I
S
T
H
T
V
Site 96
S1064
R
S
D
V
S
D
I
S
T
H
T
V
T
Y
G
Site 97
T1065
S
D
V
S
D
I
S
T
H
T
V
T
Y
G
N
Site 98
T1067
V
S
D
I
S
T
H
T
V
T
Y
G
N
I
E
Site 99
Y1070
I
S
T
H
T
V
T
Y
G
N
I
E
G
N
A
Site 100
Y1085
A
K
R
R
K
Q
Q
Y
K
D
S
L
K
K
R
Site 101
S1088
R
K
Q
Q
Y
K
D
S
L
K
K
R
P
A
S
Site 102
S1095
S
L
K
K
R
P
A
S
A
K
S
R
R
E
F
Site 103
S1098
K
R
P
A
S
A
K
S
R
R
E
F
D
E
I
Site 104
Y1109
F
D
E
I
E
L
A
Y
R
R
R
P
P
R
S
Site 105
S1116
Y
R
R
R
P
P
R
S
P
D
H
K
R
Y
F
Site 106
Y1122
R
S
P
D
H
K
R
Y
F
R
D
K
E
G
L
Site 107
Y1133
K
E
G
L
R
D
F
Y
L
D
Q
F
R
T
K
Site 108
S1143
Q
F
R
T
K
E
N
S
P
H
W
E
H
V
D
Site 109
T1152
H
W
E
H
V
D
L
T
D
I
Y
K
E
R
S
Site 110
Y1155
H
V
D
L
T
D
I
Y
K
E
R
S
D
D
F
Site 111
S1159
T
D
I
Y
K
E
R
S
D
D
F
K
R
D
S
Site 112
S1166
S
D
D
F
K
R
D
S
V
S
G
G
G
P
C
Site 113
S1168
D
F
K
R
D
S
V
S
G
G
G
P
C
T
N
Site 114
T1174
V
S
G
G
G
P
C
T
N
R
S
H
I
K
H
Site 115
S1177
G
G
P
C
T
N
R
S
H
I
K
H
G
T
G
Site 116
S1191
G
D
K
H
G
V
V
S
G
V
P
A
P
W
E
Site 117
S1217
S
G
G
N
F
C
R
S
C
P
S
K
L
H
N
Site 118
T1227
S
K
L
H
N
Y
S
T
T
V
T
G
Q
N
S
Site 119
T1228
K
L
H
N
Y
S
T
T
V
T
G
Q
N
S
G
Site 120
T1230
H
N
Y
S
T
T
V
T
G
Q
N
S
G
R
Q
Site 121
S1234
T
T
V
T
G
Q
N
S
G
R
Q
A
C
I
R
Site 122
Y1252
C
K
K
A
G
N
L
Y
D
I
S
E
D
N
S
Site 123
S1255
A
G
N
L
Y
D
I
S
E
D
N
S
L
Q
E
Site 124
S1259
Y
D
I
S
E
D
N
S
L
Q
E
L
D
Q
P
Site 125
S1274
A
A
P
V
A
V
T
S
N
A
S
T
T
K
Y
Site 126
T1278
A
V
T
S
N
A
S
T
T
K
Y
P
Q
S
P
Site 127
Y1281
S
N
A
S
T
T
K
Y
P
Q
S
P
T
N
S
Site 128
S1284
S
T
T
K
Y
P
Q
S
P
T
N
S
K
A
Q
Site 129
T1286
T
K
Y
P
Q
S
P
T
N
S
K
A
Q
K
K
Site 130
S1288
Y
P
Q
S
P
T
N
S
K
A
Q
K
K
N
R
Site 131
S1303
N
K
L
R
R
Q
H
S
Y
D
T
F
V
D
L
Site 132
Y1304
K
L
R
R
Q
H
S
Y
D
T
F
V
D
L
Q
Site 133
T1306
R
R
Q
H
S
Y
D
T
F
V
D
L
Q
K
E
Site 134
S1321
E
A
A
L
A
P
R
S
V
S
L
K
D
K
G
Site 135
S1323
A
L
A
P
R
S
V
S
L
K
D
K
G
R
F
Site 136
S1334
K
G
R
F
M
D
G
S
P
Y
A
H
M
F
E
Site 137
Y1336
R
F
M
D
G
S
P
Y
A
H
M
F
E
M
S
Site 138
S1343
Y
A
H
M
F
E
M
S
A
G
E
S
T
F
A
Site 139
S1347
F
E
M
S
A
G
E
S
T
F
A
N
N
K
S
Site 140
T1348
E
M
S
A
G
E
S
T
F
A
N
N
K
S
S
Site 141
S1354
S
T
F
A
N
N
K
S
S
V
P
T
A
G
H
Site 142
S1355
T
F
A
N
N
K
S
S
V
P
T
A
G
H
H
Site 143
S1374
P
G
G
G
Y
M
L
S
K
S
L
Y
P
D
R
Site 144
S1376
G
G
Y
M
L
S
K
S
L
Y
P
D
R
V
T
Site 145
Y1378
Y
M
L
S
K
S
L
Y
P
D
R
V
T
Q
N
Site 146
T1383
S
L
Y
P
D
R
V
T
Q
N
P
F
I
P
T
Site 147
S1403
C
L
L
H
G
S
K
S
Y
F
F
R
Q
P
T
Site 148
Y1404
L
L
H
G
S
K
S
Y
F
F
R
Q
P
T
V
Site 149
T1410
S
Y
F
F
R
Q
P
T
V
A
G
A
S
K
A
Site 150
S1415
Q
P
T
V
A
G
A
S
K
A
R
P
D
F
R
Site 151
T1426
P
D
F
R
A
L
V
T
N
K
P
V
V
S
A
Site 152
S1468
N
P
R
A
F
N
G
S
S
N
G
H
V
Y
E
Site 153
S1469
P
R
A
F
N
G
S
S
N
G
H
V
Y
E
K
Site 154
Y1474
G
S
S
N
G
H
V
Y
E
K
L
S
S
I
E
Site 155
S1478
G
H
V
Y
E
K
L
S
S
I
E
S
D
V
_
Site 156
S1479
H
V
Y
E
K
L
S
S
I
E
S
D
V
_
_
Site 157
S1482
E
K
L
S
S
I
E
S
D
V
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation