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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SFRS6
Full Name:
Serine/arginine-rich splicing factor 6
Alias:
B52; Pre-mRNA splicing factor SRP55; Pre-mRNA-splicing factor SRP55; SFR6; Splicing factor, arginine/serine-rich 6; SRP55
Type:
RNA binding protein
Mass (Da):
39587
Number AA:
344
UniProt ID:
Q13247
International Prot ID:
IPI00012345
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0000166
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006376
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
R
V
Y
I
G
R
L
S
Y
N
V
R
E
K
D
Site 2
Y11
V
Y
I
G
R
L
S
Y
N
V
R
E
K
D
I
Site 3
S23
K
D
I
Q
R
F
F
S
G
Y
G
R
L
L
E
Site 4
Y25
I
Q
R
F
F
S
G
Y
G
R
L
L
E
V
D
Site 5
Y37
E
V
D
L
K
N
G
Y
G
F
V
E
F
E
D
Site 6
S45
G
F
V
E
F
E
D
S
R
D
A
D
D
A
V
Site 7
Y53
R
D
A
D
D
A
V
Y
E
L
N
G
K
E
L
Site 8
Y80
P
R
R
D
R
D
G
Y
S
Y
G
S
R
S
G
Site 9
S81
R
R
D
R
D
G
Y
S
Y
G
S
R
S
G
G
Site 10
Y82
R
D
R
D
G
Y
S
Y
G
S
R
S
G
G
G
Site 11
S84
R
D
G
Y
S
Y
G
S
R
S
G
G
G
G
Y
Site 12
S86
G
Y
S
Y
G
S
R
S
G
G
G
G
Y
S
S
Site 13
Y91
S
R
S
G
G
G
G
Y
S
S
R
R
T
S
G
Site 14
S92
R
S
G
G
G
G
Y
S
S
R
R
T
S
G
R
Site 15
S93
S
G
G
G
G
Y
S
S
R
R
T
S
G
R
D
Site 16
T96
G
G
Y
S
S
R
R
T
S
G
R
D
K
Y
G
Site 17
S97
G
Y
S
S
R
R
T
S
G
R
D
K
Y
G
P
Site 18
Y102
R
T
S
G
R
D
K
Y
G
P
P
V
R
T
E
Site 19
Y110
G
P
P
V
R
T
E
Y
R
L
I
V
E
N
L
Site 20
S118
R
L
I
V
E
N
L
S
S
R
C
S
W
Q
D
Site 21
S119
L
I
V
E
N
L
S
S
R
C
S
W
Q
D
L
Site 22
S122
E
N
L
S
S
R
C
S
W
Q
D
L
K
D
F
Site 23
Y138
R
Q
A
G
E
V
T
Y
A
D
A
H
K
E
R
Site 24
T146
A
D
A
H
K
E
R
T
N
E
G
V
I
E
F
Site 25
S155
E
G
V
I
E
F
R
S
Y
S
D
M
K
R
A
Site 26
Y156
G
V
I
E
F
R
S
Y
S
D
M
K
R
A
L
Site 27
S157
V
I
E
F
R
S
Y
S
D
M
K
R
A
L
D
Site 28
T169
A
L
D
K
L
D
G
T
E
I
N
G
R
N
I
Site 29
T185
L
I
E
D
K
P
R
T
S
H
R
R
S
Y
S
Site 30
S186
I
E
D
K
P
R
T
S
H
R
R
S
Y
S
G
Site 31
S190
P
R
T
S
H
R
R
S
Y
S
G
S
R
S
R
Site 32
Y191
R
T
S
H
R
R
S
Y
S
G
S
R
S
R
S
Site 33
S192
T
S
H
R
R
S
Y
S
G
S
R
S
R
S
R
Site 34
S194
H
R
R
S
Y
S
G
S
R
S
R
S
R
S
R
Site 35
S196
R
S
Y
S
G
S
R
S
R
S
R
S
R
R
R
Site 36
S198
Y
S
G
S
R
S
R
S
R
S
R
R
R
S
R
Site 37
S200
G
S
R
S
R
S
R
S
R
R
R
S
R
S
R
Site 38
S204
R
S
R
S
R
R
R
S
R
S
R
S
R
R
S
Site 39
S206
R
S
R
R
R
S
R
S
R
S
R
R
S
S
R
Site 40
S208
R
R
R
S
R
S
R
S
R
R
S
S
R
S
R
Site 41
S211
S
R
S
R
S
R
R
S
S
R
S
R
S
R
S
Site 42
S212
R
S
R
S
R
R
S
S
R
S
R
S
R
S
I
Site 43
S214
R
S
R
R
S
S
R
S
R
S
R
S
I
S
K
Site 44
S216
R
R
S
S
R
S
R
S
R
S
I
S
K
S
R
Site 45
S218
S
S
R
S
R
S
R
S
I
S
K
S
R
S
R
Site 46
S220
R
S
R
S
R
S
I
S
K
S
R
S
R
S
R
Site 47
S222
R
S
R
S
I
S
K
S
R
S
R
S
R
S
R
Site 48
S224
R
S
I
S
K
S
R
S
R
S
R
S
R
S
K
Site 49
S226
I
S
K
S
R
S
R
S
R
S
R
S
K
G
R
Site 50
S228
K
S
R
S
R
S
R
S
R
S
K
G
R
S
R
Site 51
S230
R
S
R
S
R
S
R
S
K
G
R
S
R
S
R
Site 52
S234
R
S
R
S
K
G
R
S
R
S
R
S
K
G
R
Site 53
S236
R
S
K
G
R
S
R
S
R
S
K
G
R
K
S
Site 54
S238
K
G
R
S
R
S
R
S
K
G
R
K
S
R
S
Site 55
S243
S
R
S
K
G
R
K
S
R
S
K
S
K
S
K
Site 56
S245
S
K
G
R
K
S
R
S
K
S
K
S
K
P
K
Site 57
S247
G
R
K
S
R
S
K
S
K
S
K
P
K
S
D
Site 58
S249
K
S
R
S
K
S
K
S
K
P
K
S
D
R
G
Site 59
S253
K
S
K
S
K
P
K
S
D
R
G
S
H
S
H
Site 60
S257
K
P
K
S
D
R
G
S
H
S
H
S
R
S
R
Site 61
S259
K
S
D
R
G
S
H
S
H
S
R
S
R
S
K
Site 62
S261
D
R
G
S
H
S
H
S
R
S
R
S
K
D
E
Site 63
S263
G
S
H
S
H
S
R
S
R
S
K
D
E
Y
E
Site 64
S265
H
S
H
S
R
S
R
S
K
D
E
Y
E
K
S
Site 65
Y269
R
S
R
S
K
D
E
Y
E
K
S
R
S
R
S
Site 66
S272
S
K
D
E
Y
E
K
S
R
S
R
S
R
S
R
Site 67
S274
D
E
Y
E
K
S
R
S
R
S
R
S
R
S
P
Site 68
S276
Y
E
K
S
R
S
R
S
R
S
R
S
P
K
E
Site 69
S278
K
S
R
S
R
S
R
S
R
S
P
K
E
N
G
Site 70
S280
R
S
R
S
R
S
R
S
P
K
E
N
G
K
G
Site 71
S291
N
G
K
G
D
I
K
S
K
S
R
S
R
S
Q
Site 72
S293
K
G
D
I
K
S
K
S
R
S
R
S
Q
S
R
Site 73
S295
D
I
K
S
K
S
R
S
R
S
Q
S
R
S
N
Site 74
S297
K
S
K
S
R
S
R
S
Q
S
R
S
N
S
P
Site 75
S299
K
S
R
S
R
S
Q
S
R
S
N
S
P
L
P
Site 76
S301
R
S
R
S
Q
S
R
S
N
S
P
L
P
V
P
Site 77
S303
R
S
Q
S
R
S
N
S
P
L
P
V
P
P
S
Site 78
S310
S
P
L
P
V
P
P
S
K
A
R
S
V
S
P
Site 79
S314
V
P
P
S
K
A
R
S
V
S
P
P
P
K
R
Site 80
S316
P
S
K
A
R
S
V
S
P
P
P
K
R
A
T
Site 81
T323
S
P
P
P
K
R
A
T
S
R
S
R
S
R
S
Site 82
S324
P
P
P
K
R
A
T
S
R
S
R
S
R
S
R
Site 83
S326
P
K
R
A
T
S
R
S
R
S
R
S
R
S
K
Site 84
S328
R
A
T
S
R
S
R
S
R
S
R
S
K
S
R
Site 85
S330
T
S
R
S
R
S
R
S
R
S
K
S
R
S
R
Site 86
S332
R
S
R
S
R
S
R
S
K
S
R
S
R
S
R
Site 87
S334
R
S
R
S
R
S
K
S
R
S
R
S
R
S
S
Site 88
S336
R
S
R
S
K
S
R
S
R
S
R
S
S
S
R
Site 89
S338
R
S
K
S
R
S
R
S
R
S
S
S
R
D
_
Site 90
S340
K
S
R
S
R
S
R
S
S
S
R
D
_
_
_
Site 91
S341
S
R
S
R
S
R
S
S
S
R
D
_
_
_
_
Site 92
S342
R
S
R
S
R
S
S
S
R
D
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation