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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
G3BP1
Full Name:
Ras GTPase-activating protein-binding protein 1
Alias:
ATP-dependent DNA helicase VIII; G3BP; G3BP-1; GAP SH3 domain-binding protein 1; HDH-VIII
Type:
Adaptor/scaffold; Helicase; EC 3.6.1.-
Mass (Da):
52164
Number AA:
466
UniProt ID:
Q13283
International Prot ID:
IPI00012442
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005634
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004003
GO:0004004
PhosphoSite+
KinaseNET
Biological Process:
GO:0007265
GO:0006810
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
V
M
E
K
P
S
P
L
L
V
G
R
E
Site 2
Y19
G
R
E
F
V
R
Q
Y
Y
T
L
L
N
Q
A
Site 3
Y20
R
E
F
V
R
Q
Y
Y
T
L
L
N
Q
A
P
Site 4
Y34
P
D
M
L
H
R
F
Y
G
K
N
S
S
Y
V
Site 5
S39
R
F
Y
G
K
N
S
S
Y
V
H
G
G
L
D
Site 6
Y40
F
Y
G
K
N
S
S
Y
V
H
G
G
L
D
S
Site 7
Y56
G
K
P
A
D
A
V
Y
G
Q
K
E
I
H
R
Site 8
S99
V
Q
V
M
G
L
L
S
N
N
N
Q
A
L
R
Site 9
Y125
G
S
V
A
N
K
F
Y
V
H
N
D
I
F
R
Site 10
Y133
V
H
N
D
I
F
R
Y
Q
D
E
V
F
G
G
Site 11
T143
E
V
F
G
G
F
V
T
E
P
Q
E
E
S
E
Site 12
S149
V
T
E
P
Q
E
E
S
E
E
E
V
E
E
P
Site 13
T162
E
P
E
E
R
Q
Q
T
P
E
V
V
P
D
D
Site 14
S170
P
E
V
V
P
D
D
S
G
T
F
Y
D
Q
A
Site 15
T172
V
V
P
D
D
S
G
T
F
Y
D
Q
A
V
V
Site 16
Y174
P
D
D
S
G
T
F
Y
D
Q
A
V
V
S
N
Site 17
S208
E
P
E
Q
E
P
V
S
E
I
Q
E
E
K
P
Site 18
T222
P
E
P
V
L
E
E
T
A
P
E
D
A
Q
K
Site 19
S230
A
P
E
D
A
Q
K
S
S
S
P
A
P
A
D
Site 20
S231
P
E
D
A
Q
K
S
S
S
P
A
P
A
D
I
Site 21
S232
E
D
A
Q
K
S
S
S
P
A
P
A
D
I
A
Site 22
T241
A
P
A
D
I
A
Q
T
V
Q
E
D
L
R
T
Site 23
T248
T
V
Q
E
D
L
R
T
F
S
W
A
S
V
T
Site 24
S250
Q
E
D
L
R
T
F
S
W
A
S
V
T
S
K
Site 25
S253
L
R
T
F
S
W
A
S
V
T
S
K
N
L
P
Site 26
S256
F
S
W
A
S
V
T
S
K
N
L
P
P
S
G
Site 27
S262
T
S
K
N
L
P
P
S
G
A
V
P
V
T
G
Site 28
T268
P
S
G
A
V
P
V
T
G
I
P
P
H
V
V
Site 29
S280
H
V
V
K
V
P
A
S
Q
P
R
P
E
S
K
Site 30
S286
A
S
Q
P
R
P
E
S
K
P
E
S
Q
I
P
Site 31
S290
R
P
E
S
K
P
E
S
Q
I
P
P
Q
R
P
Site 32
S354
L
P
H
E
V
D
K
S
E
L
K
D
F
F
Q
Site 33
Y363
L
K
D
F
F
Q
S
Y
G
N
V
V
E
L
R
Site 34
S373
V
V
E
L
R
I
N
S
G
G
K
L
P
N
F
Site 35
S388
G
F
V
V
F
D
D
S
E
P
V
Q
K
V
L
Site 36
S396
E
P
V
Q
K
V
L
S
N
R
P
I
M
F
R
Site 37
T415
L
N
V
E
E
K
K
T
R
A
A
R
E
G
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation