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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PABPC4
Full Name:
Polyadenylate-binding protein 4
Alias:
Activated-platelet protein-1; APP1; APP-1; Inducible poly(A)-binding protein; IPABP; PAB4; PABP4; Poly (A) binding protein, cytoplasmic 4 (inducible form); Poly(A)-binding protein 4
Type:
RNA binding protein
Mass (Da):
70783
Number AA:
644
UniProt ID:
Q13310
International Prot ID:
IPI00012726
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0030529
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0008143
GO:0008266
PhosphoSite+
KinaseNET
Biological Process:
GO:0006401
GO:0006396
GO:0007596
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y14
S
Y
P
M
A
S
L
Y
V
G
D
L
H
S
D
Site 2
T23
G
D
L
H
S
D
V
T
E
A
M
L
Y
E
K
Site 3
Y28
D
V
T
E
A
M
L
Y
E
K
F
S
P
A
G
Site 4
S39
S
P
A
G
P
V
L
S
I
R
V
C
R
D
M
Site 5
T48
R
V
C
R
D
M
I
T
R
R
S
L
G
Y
A
Site 6
S51
R
D
M
I
T
R
R
S
L
G
Y
A
Y
V
N
Site 7
Y54
I
T
R
R
S
L
G
Y
A
Y
V
N
F
Q
Q
Site 8
Y56
R
R
S
L
G
Y
A
Y
V
N
F
Q
Q
P
A
Site 9
T71
D
A
E
R
A
L
D
T
M
N
F
D
V
I
K
Site 10
S87
K
P
I
R
I
M
W
S
Q
R
D
P
S
L
R
Site 11
S92
M
W
S
Q
R
D
P
S
L
R
K
S
G
V
G
Site 12
S96
R
D
P
S
L
R
K
S
G
V
G
N
V
F
I
Site 13
S109
F
I
K
N
L
D
K
S
I
D
N
K
A
L
Y
Site 14
Y116
S
I
D
N
K
A
L
Y
D
T
F
S
A
F
G
Site 15
T118
D
N
K
A
L
Y
D
T
F
S
A
F
G
N
I
Site 16
Y140
D
E
N
G
S
K
G
Y
A
F
V
H
F
E
T
Site 17
S175
V
F
V
G
R
F
K
S
R
K
E
R
E
A
E
Site 18
T191
G
A
K
A
K
E
F
T
N
V
Y
I
K
N
F
Site 19
Y194
A
K
E
F
T
N
V
Y
I
K
N
F
G
E
E
Site 20
S206
G
E
E
V
D
D
E
S
L
K
E
L
F
S
Q
Site 21
S212
E
S
L
K
E
L
F
S
Q
F
G
K
T
L
S
Site 22
S219
S
Q
F
G
K
T
L
S
V
K
V
M
R
D
P
Site 23
S230
M
R
D
P
N
G
K
S
K
G
F
G
F
V
S
Site 24
S237
S
K
G
F
G
F
V
S
Y
E
K
H
E
D
A
Site 25
Y238
K
G
F
G
F
V
S
Y
E
K
H
E
D
A
N
Site 26
S289
Q
L
K
Q
E
R
I
S
R
Y
Q
G
V
N
L
Site 27
Y291
K
Q
E
R
I
S
R
Y
Q
G
V
N
L
Y
I
Site 28
Y297
R
Y
Q
G
V
N
L
Y
I
K
N
L
D
D
T
Site 29
T304
Y
I
K
N
L
D
D
T
I
D
D
E
K
L
R
Site 30
S315
E
K
L
R
K
E
F
S
P
F
G
S
I
T
S
Site 31
S319
K
E
F
S
P
F
G
S
I
T
S
A
K
V
M
Site 32
S341
G
F
G
F
V
C
F
S
S
P
E
E
A
T
K
Site 33
S342
F
G
F
V
C
F
S
S
P
E
E
A
T
K
A
Site 34
S360
M
N
G
R
I
V
G
S
K
P
L
Y
V
A
L
Site 35
Y364
I
V
G
S
K
P
L
Y
V
A
L
A
Q
R
K
Site 36
T379
E
E
R
K
A
H
L
T
N
Q
Y
M
Q
R
V
Site 37
Y382
K
A
H
L
T
N
Q
Y
M
Q
R
V
A
G
M
Site 38
Y422
Q
A
Q
G
R
P
P
Y
Y
T
P
N
Q
L
A
Site 39
Y423
A
Q
G
R
P
P
Y
Y
T
P
N
Q
L
A
Q
Site 40
T424
Q
G
R
P
P
Y
Y
T
P
N
Q
L
A
Q
M
Site 41
S451
Q
G
F
Q
G
M
P
S
A
I
R
Q
S
G
P
Site 42
S456
M
P
S
A
I
R
Q
S
G
P
R
P
T
L
R
Site 43
T461
R
Q
S
G
P
R
P
T
L
R
H
L
A
P
T
Site 44
T468
T
L
R
H
L
A
P
T
G
S
E
C
P
D
R
Site 45
S470
R
H
L
A
P
T
G
S
E
C
P
D
R
L
A
Site 46
T491
G
A
A
Q
Q
G
L
T
D
S
C
Q
S
G
G
Site 47
S493
A
Q
Q
G
L
T
D
S
C
Q
S
G
G
V
P
Site 48
Y523
A
P
R
A
V
A
P
Y
K
Y
A
S
S
V
R
Site 49
Y525
R
A
V
A
P
Y
K
Y
A
S
S
V
R
S
P
Site 50
S527
V
A
P
Y
K
Y
A
S
S
V
R
S
P
H
P
Site 51
S528
A
P
Y
K
Y
A
S
S
V
R
S
P
H
P
A
Site 52
S531
K
Y
A
S
S
V
R
S
P
H
P
A
I
Q
P
Site 53
S557
G
Q
E
P
L
T
A
S
M
L
A
A
A
P
P
Site 54
S600
M
L
L
E
I
D
N
S
E
L
L
H
M
L
E
Site 55
S608
E
L
L
H
M
L
E
S
P
E
S
L
R
S
K
Site 56
S611
H
M
L
E
S
P
E
S
L
R
S
K
V
D
E
Site 57
S614
E
S
P
E
S
L
R
S
K
V
D
E
A
V
A
Site 58
S644
G
A
V
A
A
A
T
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation