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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Grb10
Full Name:
Growth factor receptor-bound protein 10
Alias:
GRB10 adaptor protein; GRBIR; Insulin receptor binding protein GRB-IR; KIAA0207
Type:
Adapter/scaffold protein
Mass (Da):
67231
Number AA:
594
UniProt ID:
Q13322
International Prot ID:
IPI00218909
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005070
GO:0005158
PhosphoSite+
KinaseNET
Biological Process:
GO:0007267
GO:0008286
GO:0046325
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
S
F
L
H
H
P
Y
Y
Q
D
K
V
E
Q
T
Site 2
T23
Y
Q
D
K
V
E
Q
T
P
R
S
Q
Q
D
P
Site 3
S26
K
V
E
Q
T
P
R
S
Q
Q
D
P
A
G
P
Site 4
S39
G
P
G
L
P
A
Q
S
D
R
L
A
N
H
Q
Site 5
S62
L
V
N
D
M
N
A
S
L
E
S
L
Y
S
A
Site 6
S65
D
M
N
A
S
L
E
S
L
Y
S
A
C
S
M
Site 7
Y67
N
A
S
L
E
S
L
Y
S
A
C
S
M
Q
S
Site 8
S68
A
S
L
E
S
L
Y
S
A
C
S
M
Q
S
D
Site 9
S71
E
S
L
Y
S
A
C
S
M
Q
S
D
T
V
P
Site 10
S74
Y
S
A
C
S
M
Q
S
D
T
V
P
L
L
Q
Site 11
T76
A
C
S
M
Q
S
D
T
V
P
L
L
Q
N
G
Site 12
S88
Q
N
G
Q
H
A
R
S
Q
P
R
A
S
G
P
Site 13
S93
A
R
S
Q
P
R
A
S
G
P
P
R
S
I
Q
Site 14
S98
R
A
S
G
P
P
R
S
I
Q
P
Q
V
S
P
Site 15
S104
R
S
I
Q
P
Q
V
S
P
R
Q
R
V
Q
R
Site 16
S112
P
R
Q
R
V
Q
R
S
Q
P
V
H
I
L
A
Site 17
S133
P
E
L
C
G
P
G
S
P
P
V
L
T
P
G
Site 18
S134
D
Q
Q
F
R
T
S
S
L
P
A
I
P
N
P
Site 19
S150
P
E
L
C
G
P
G
S
P
P
V
L
T
P
G
Site 20
T155
P
G
S
P
P
V
L
T
P
G
S
L
P
P
S
Site 21
S158
P
P
V
L
T
P
G
S
L
P
P
S
Q
A
A
Site 22
S162
T
P
G
S
L
P
P
S
Q
A
A
A
K
Q
D
Site 23
S179
V
F
S
E
D
G
T
S
K
V
V
E
I
L
A
Site 24
S235
E
L
V
V
Q
V
E
S
T
M
A
S
E
S
K
Site 25
S239
Q
V
E
S
T
M
A
S
E
S
K
F
L
F
R
Site 26
Y249
K
F
L
F
R
K
N
Y
A
K
Y
E
F
F
K
Site 27
Y252
F
R
K
N
Y
A
K
Y
E
F
F
K
N
P
M
Site 28
T268
F
F
P
E
Q
M
V
T
W
C
Q
Q
S
N
G
Site 29
S287
L
L
Q
N
F
L
N
S
S
S
C
P
E
I
Q
Site 30
S289
Q
N
F
L
N
S
S
S
C
P
E
I
Q
G
F
Site 31
S306
V
K
E
L
G
K
K
S
W
K
K
L
Y
V
C
Site 32
Y311
K
K
S
W
K
K
L
Y
V
C
L
R
R
S
G
Site 33
Y320
C
L
R
R
S
G
L
Y
C
S
T
K
G
T
S
Site 34
S322
R
R
S
G
L
Y
C
S
T
K
G
T
S
K
E
Site 35
S346
L
E
D
S
N
I
F
S
L
I
A
G
R
K
Q
Site 36
Y354
L
I
A
G
R
K
Q
Y
N
A
P
T
D
H
G
Site 37
T373
P
N
K
V
R
N
E
T
K
E
L
R
L
L
C
Site 38
T388
A
E
D
E
Q
T
R
T
C
W
M
T
A
F
R
Site 39
Y404
L
K
Y
G
M
L
L
Y
Q
N
Y
R
I
P
Q
Site 40
Y407
G
M
L
L
Y
Q
N
Y
R
I
P
Q
Q
R
K
Site 41
S418
Q
Q
R
K
A
L
L
S
P
F
S
T
P
V
R
Site 42
S421
K
A
L
L
S
P
F
S
T
P
V
R
S
V
S
Site 43
T422
A
L
L
S
P
F
S
T
P
V
R
S
V
S
E
Site 44
S426
P
F
S
T
P
V
R
S
V
S
E
N
S
L
V
Site 45
S428
S
T
P
V
R
S
V
S
E
N
S
L
V
A
M
Site 46
S431
V
R
S
V
S
E
N
S
L
V
A
M
D
F
S
Site 47
S453
E
N
P
A
E
A
Q
S
A
A
L
E
E
G
H
Site 48
S466
G
H
A
W
R
K
R
S
T
R
M
N
I
L
G
Site 49
T467
H
A
W
R
K
R
S
T
R
M
N
I
L
G
S
Site 50
S474
T
R
M
N
I
L
G
S
Q
S
P
L
H
P
S
Site 51
S476
M
N
I
L
G
S
Q
S
P
L
H
P
S
T
L
Site 52
S481
S
Q
S
P
L
H
P
S
T
L
S
T
V
I
H
Site 53
T482
Q
S
P
L
H
P
S
T
L
S
T
V
I
H
R
Site 54
T485
L
H
P
S
T
L
S
T
V
I
H
R
T
Q
H
Site 55
T490
L
S
T
V
I
H
R
T
Q
H
W
F
H
G
R
Site 56
S503
G
R
I
S
R
E
E
S
H
R
I
I
K
Q
Q
Site 57
S522
G
L
F
L
L
R
D
S
Q
S
N
P
K
A
F
Site 58
S524
F
L
L
R
D
S
Q
S
N
P
K
A
F
V
L
Site 59
T553
P
C
E
D
D
G
Q
T
F
F
S
L
D
D
G
Site 60
S556
D
D
G
Q
T
F
F
S
L
D
D
G
N
T
K
Site 61
T562
F
S
L
D
D
G
N
T
K
F
S
D
L
I
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation