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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTPRS
Full Name:
Receptor-type tyrosine-protein phosphatase S
Alias:
EC 3.1.3.48; R-PTP-S
Type:
Membrane, Integral plasma membrane protein
Mass (Da):
217094
Number AA:
1948
UniProt ID:
Q13332
International Prot ID:
IPI00289831
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
GO:0016020
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004721
GO:0004725
PhosphoSite+
KinaseNET
Biological Process:
GO:0006464
GO:0006470
GO:0006793
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y214
E
E
T
D
Q
G
K
Y
E
C
V
A
T
N
S
Site 2
S396
I
G
G
L
S
P
N
S
E
Y
E
I
W
V
S
Site 3
Y556
R
Q
E
S
I
I
K
Y
E
L
L
F
R
E
G
Site 4
Y692
A
L
E
K
W
T
Q
Y
R
I
T
T
V
A
H
Site 5
S708
E
V
G
P
G
P
E
S
S
P
V
V
V
R
T
Site 6
T876
E
D
S
T
P
L
A
T
L
E
F
P
P
S
E
Site 7
T880
E
D
S
T
P
L
A
T
L
E
F
P
P
S
E
Site 8
T891
P
P
S
E
D
R
Y
T
A
S
G
V
H
K
G
Site 9
S893
S
E
D
R
Y
T
A
S
G
V
H
K
G
A
T
Site 10
Y965
R
N
G
A
I
V
K
Y
T
V
A
V
R
E
A
Site 11
S1312
L
Y
K
N
K
P
D
S
K
R
K
D
S
E
P
Site 12
S1317
P
D
S
K
R
K
D
S
E
P
R
T
K
C
L
Site 13
T1321
R
K
D
S
E
P
R
T
K
C
L
L
N
N
A
Site 14
T1348
M
R
R
I
N
F
Q
T
P
D
S
G
L
R
S
Site 15
S1351
I
N
F
Q
T
P
D
S
G
L
R
S
P
L
R
Site 16
S1355
T
P
D
S
G
L
R
S
P
L
R
E
P
G
F
Site 17
S1366
E
P
G
F
H
F
E
S
M
L
S
H
P
P
I
Site 18
S1390
E
R
L
K
A
N
D
S
L
K
L
S
Q
E
Y
Site 19
S1394
A
N
D
S
L
K
L
S
Q
E
Y
E
S
I
D
Site 20
Y1397
S
L
K
L
S
Q
E
Y
E
S
I
D
P
G
Q
Site 21
Y1422
V
N
K
P
K
N
R
Y
A
N
V
I
A
Y
D
Site 22
Y1428
R
Y
A
N
V
I
A
Y
D
H
S
R
V
I
L
Site 23
S1431
N
V
I
A
Y
D
H
S
R
V
I
L
Q
P
I
Site 24
Y1446
E
G
I
M
G
S
D
Y
I
N
A
N
Y
V
D
Site 25
Y1451
S
D
Y
I
N
A
N
Y
V
D
G
Y
R
R
Q
Site 26
Y1455
N
A
N
Y
V
D
G
Y
R
R
Q
N
A
Y
I
Site 27
Y1461
G
Y
R
R
Q
N
A
Y
I
A
T
Q
G
P
L
Site 28
T1464
R
Q
N
A
Y
I
A
T
Q
G
P
L
P
E
T
Site 29
T1471
T
Q
G
P
L
P
E
T
F
G
D
F
W
R
M
Site 30
S1484
R
M
V
W
E
Q
R
S
A
T
I
V
M
M
T
Site 31
T1486
V
W
E
Q
R
S
A
T
I
V
M
M
T
R
L
Site 32
S1497
M
T
R
L
E
E
K
S
R
I
K
C
D
Q
Y
Site 33
Y1504
S
R
I
K
C
D
Q
Y
W
P
N
R
G
T
E
Site 34
Y1513
P
N
R
G
T
E
T
Y
G
F
I
Q
V
T
L
Site 35
S1535
T
F
C
V
R
T
F
S
L
H
K
N
G
S
S
Site 36
S1541
F
S
L
H
K
N
G
S
S
E
K
R
E
V
R
Site 37
S1542
S
L
H
K
N
G
S
S
E
K
R
E
V
R
Q
Site 38
Y1563
P
D
H
G
V
P
E
Y
P
T
P
F
L
A
F
Site 39
T1576
A
F
L
R
R
V
K
T
C
N
P
P
D
A
G
Site 40
T1596
C
S
A
G
V
G
R
T
G
C
F
I
V
I
D
Site 41
T1614
E
R
I
K
P
E
K
T
V
D
V
Y
G
H
V
Site 42
Y1618
P
E
K
T
V
D
V
Y
G
H
V
T
L
M
R
Site 43
T1622
V
D
V
Y
G
H
V
T
L
M
R
S
Q
R
N
Site 44
Y1630
L
M
R
S
Q
R
N
Y
M
V
Q
T
E
D
Q
Site 45
Y1638
M
V
Q
T
E
D
Q
Y
S
F
I
H
E
A
L
Site 46
S1639
V
Q
T
E
D
Q
Y
S
F
I
H
E
A
L
L
Site 47
Y1662
E
V
P
A
R
S
L
Y
A
Y
I
Q
K
L
A
Site 48
Y1664
P
A
R
S
L
Y
A
Y
I
Q
K
L
A
Q
V
Site 49
S1690
E
F
K
R
L
A
N
S
K
A
H
T
S
R
F
Site 50
T1694
L
A
N
S
K
A
H
T
S
R
F
I
S
A
N
Site 51
S1695
A
N
S
K
A
H
T
S
R
F
I
S
A
N
L
Site 52
S1699
A
H
T
S
R
F
I
S
A
N
L
P
C
N
K
Site 53
Y1717
R
L
V
N
I
M
P
Y
E
S
T
R
V
C
L
Site 54
T1720
N
I
M
P
Y
E
S
T
R
V
C
L
Q
P
I
Site 55
S1733
P
I
R
G
V
E
G
S
D
Y
I
N
A
S
F
Site 56
Y1735
R
G
V
E
G
S
D
Y
I
N
A
S
F
I
D
Site 57
S1739
G
S
D
Y
I
N
A
S
F
I
D
G
Y
R
Q
Site 58
Y1744
N
A
S
F
I
D
G
Y
R
Q
Q
K
A
Y
I
Site 59
Y1750
G
Y
R
Q
Q
K
A
Y
I
A
T
Q
G
P
L
Site 60
Y1793
G
R
E
K
C
H
Q
Y
W
P
A
E
R
S
A
Site 61
Y1804
E
R
S
A
R
Y
Q
Y
F
V
V
D
P
M
A
Site 62
Y1818
A
E
Y
N
M
P
Q
Y
I
L
R
E
F
K
V
Site 63
T1826
I
L
R
E
F
K
V
T
D
A
R
D
G
Q
S
Site 64
S1833
T
D
A
R
D
G
Q
S
R
T
V
R
Q
F
Q
Site 65
T1835
A
R
D
G
Q
S
R
T
V
R
Q
F
Q
F
T
Site 66
S1852
P
E
Q
G
V
P
K
S
G
E
G
F
I
D
F
Site 67
T1866
F
I
G
Q
V
H
K
T
K
E
Q
F
G
Q
D
Site 68
T1917
Q
T
V
K
M
L
R
T
Q
R
P
A
M
V
Q
Site 69
Y1929
M
V
Q
T
E
D
E
Y
Q
F
C
Y
Q
A
A
Site 70
Y1933
E
D
E
Y
Q
F
C
Y
Q
A
A
L
E
Y
L
Site 71
Y1939
C
Y
Q
A
A
L
E
Y
L
G
S
F
D
H
Y
Site 72
S1942
A
A
L
E
Y
L
G
S
F
D
H
Y
A
T
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation