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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPIL2
Full Name:
Peptidyl-prolyl cis-trans isomerase-like 2
Alias:
Cyclophilin-60;Cyclophilin-like protein Cyp-60;Rotamase PPIL2
Type:
Mass (Da):
58823
Number AA:
520
UniProt ID:
Q13356
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y12
Q
H
Q
K
D
K
M
Y
I
T
C
A
E
Y
T
Site 2
Y18
M
Y
I
T
C
A
E
Y
T
H
F
Y
G
G
K
Site 3
T32
K
K
P
D
L
P
Q
T
N
F
R
R
L
P
F
Site 4
S45
P
F
D
H
C
S
L
S
L
Q
P
F
V
Y
P
Site 5
Y73
I
V
P
W
L
K
K
Y
G
T
N
P
S
N
G
Site 6
T75
P
W
L
K
K
Y
G
T
N
P
S
N
G
E
K
Site 7
S78
K
K
Y
G
T
N
P
S
N
G
E
K
L
D
G
Site 8
Y101
S
K
N
S
E
G
K
Y
H
C
P
V
L
F
T
Site 9
Y128
T
T
G
N
V
Y
A
Y
E
A
V
E
Q
L
N
Site 10
T146
K
N
F
R
D
L
L
T
D
E
P
F
S
R
Q
Site 11
T157
F
S
R
Q
D
I
I
T
L
Q
D
P
T
N
L
Site 12
Y173
K
F
N
V
S
N
F
Y
H
V
K
N
N
M
K
Site 13
S194
E
K
A
K
Q
D
P
S
Y
Y
L
K
N
T
N
Site 14
Y195
K
A
K
Q
D
P
S
Y
Y
L
K
N
T
N
A
Site 15
Y196
A
K
Q
D
P
S
Y
Y
L
K
N
T
N
A
E
Site 16
T207
T
N
A
E
T
R
E
T
L
Q
E
L
Y
K
E
Site 17
Y212
R
E
T
L
Q
E
L
Y
K
E
F
K
G
D
E
Site 18
S242
K
L
N
A
A
H
Y
S
T
G
K
V
S
A
S
Site 19
Y281
Q
F
V
K
K
K
G
Y
V
R
L
H
T
N
K
Site 20
T286
K
G
Y
V
R
L
H
T
N
K
G
D
L
N
L
Site 21
T300
L
E
L
H
C
D
L
T
P
K
T
C
E
N
F
Site 22
Y315
I
R
L
C
K
K
H
Y
Y
D
G
T
I
F
H
Site 23
Y316
R
L
C
K
K
H
Y
Y
D
G
T
I
F
H
R
Site 24
T319
K
K
H
Y
Y
D
G
T
I
F
H
R
S
I
R
Site 25
T336
V
I
Q
G
G
D
P
T
G
T
G
T
G
G
E
Site 26
T338
Q
G
G
D
P
T
G
T
G
T
G
G
E
S
Y
Site 27
T340
G
D
P
T
G
T
G
T
G
G
E
S
Y
W
G
Site 28
S344
G
T
G
T
G
G
E
S
Y
W
G
K
P
F
K
Site 29
Y345
T
G
T
G
G
E
S
Y
W
G
K
P
F
K
D
Site 30
S359
D
E
F
R
P
N
L
S
H
T
G
R
G
I
L
Site 31
T361
F
R
P
N
L
S
H
T
G
R
G
I
L
S
M
Site 32
S367
H
T
G
R
G
I
L
S
M
A
N
S
G
P
N
Site 33
S371
G
I
L
S
M
A
N
S
G
P
N
S
N
R
S
Site 34
S375
M
A
N
S
G
P
N
S
N
R
S
Q
F
F
I
Site 35
S378
S
G
P
N
S
N
R
S
Q
F
F
I
T
F
R
Site 36
T383
N
R
S
Q
F
F
I
T
F
R
S
C
A
Y
L
Site 37
T395
A
Y
L
D
K
K
H
T
I
F
G
R
V
V
G
Site 38
S415
T
A
M
E
N
V
E
S
D
P
K
T
D
R
P
Site 39
T419
N
V
E
S
D
P
K
T
D
R
P
K
E
E
I
Site 40
T431
E
E
I
R
I
D
A
T
T
V
F
V
D
P
Y
Site 41
T432
E
I
R
I
D
A
T
T
V
F
V
D
P
Y
E
Site 42
Y438
T
T
V
F
V
D
P
Y
E
E
A
D
A
Q
I
Site 43
T451
Q
I
A
Q
E
R
K
T
Q
L
K
V
A
P
E
Site 44
T459
Q
L
K
V
A
P
E
T
K
V
K
S
S
Q
P
Site 45
S463
A
P
E
T
K
V
K
S
S
Q
P
Q
A
G
S
Site 46
S464
P
E
T
K
V
K
S
S
Q
P
Q
A
G
S
Q
Site 47
S470
S
S
Q
P
Q
A
G
S
Q
G
P
Q
T
F
R
Site 48
T475
A
G
S
Q
G
P
Q
T
F
R
Q
G
V
G
K
Site 49
Y483
F
R
Q
G
V
G
K
Y
I
N
P
A
A
T
K
Site 50
S498
R
A
A
E
E
E
P
S
T
S
A
T
V
P
M
Site 51
T499
A
A
E
E
E
P
S
T
S
A
T
V
P
M
S
Site 52
S500
A
E
E
E
P
S
T
S
A
T
V
P
M
S
K
Site 53
T502
E
E
P
S
T
S
A
T
V
P
M
S
K
K
K
Site 54
S506
T
S
A
T
V
P
M
S
K
K
K
P
S
R
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation