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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AP3B2
Full Name:
AP-3 complex subunit beta-2
Alias:
Beta3B-adaptin; Clathrin assembly protein complex 3 beta-2 large chain; Neuron-specific vesicle coat protein beta-NAP
Type:
Vesicle protein
Mass (Da):
119059
Number AA:
1082
UniProt ID:
Q13367
International Prot ID:
IPI00005793
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030137
GO:0030117
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008565
PhosphoSite+
KinaseNET
Biological Process:
GO:0006897
GO:0006886
GO:0006892
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
S
A
A
P
A
Y
S
E
D
K
G
G
S
Site 2
S8
M
S
A
A
P
A
Y
S
E
D
K
G
G
S
A
Site 3
S14
Y
S
E
D
K
G
G
S
A
G
P
G
E
P
E
Site 4
Y22
A
G
P
G
E
P
E
Y
G
H
D
P
A
S
G
Site 5
S28
E
Y
G
H
D
P
A
S
G
G
I
F
S
S
D
Site 6
S33
P
A
S
G
G
I
F
S
S
D
Y
K
R
H
D
Site 7
S34
A
S
G
G
I
F
S
S
D
Y
K
R
H
D
D
Site 8
Y36
G
G
I
F
S
S
D
Y
K
R
H
D
D
L
K
Site 9
T48
D
L
K
E
M
L
D
T
N
K
D
S
L
K
L
Site 10
S52
M
L
D
T
N
K
D
S
L
K
L
E
A
M
K
Site 11
Y96
V
K
K
L
V
Y
V
Y
L
V
R
Y
A
E
E
Site 12
S111
Q
Q
D
L
A
L
L
S
I
S
T
F
Q
R
G
Site 13
T114
L
A
L
L
S
I
S
T
F
Q
R
G
L
K
D
Site 14
S135
A
S
A
L
R
V
L
S
S
I
R
V
P
I
I
Site 15
S136
S
A
L
R
V
L
S
S
I
R
V
P
I
I
V
Site 16
S155
L
A
I
K
E
A
A
S
D
M
S
P
Y
V
R
Site 17
S158
K
E
A
A
S
D
M
S
P
Y
V
R
K
T
A
Site 18
Y160
A
A
S
D
M
S
P
Y
V
R
K
T
A
A
H
Site 19
T164
M
S
P
Y
V
R
K
T
A
A
H
A
I
P
K
Site 20
Y173
A
H
A
I
P
K
L
Y
S
L
D
S
D
Q
K
Site 21
S174
H
A
I
P
K
L
Y
S
L
D
S
D
Q
K
D
Site 22
S177
P
K
L
Y
S
L
D
S
D
Q
K
D
Q
L
I
Site 23
S253
Y
A
R
T
Q
F
L
S
P
T
Q
N
E
S
L
Site 24
T255
R
T
Q
F
L
S
P
T
Q
N
E
S
L
L
E
Site 25
S259
L
S
P
T
Q
N
E
S
L
L
E
E
N
A
E
Site 26
Y270
E
N
A
E
K
A
F
Y
G
S
E
E
D
E
A
Site 27
S272
A
E
K
A
F
Y
G
S
E
E
D
E
A
K
G
Site 28
S282
D
E
A
K
G
A
G
S
E
E
T
A
A
A
A
Site 29
Y296
A
A
P
S
R
K
P
Y
V
M
D
P
D
H
R
Site 30
T309
H
R
L
L
L
R
N
T
K
P
L
L
Q
S
R
Site 31
Y356
R
S
H
S
E
V
Q
Y
V
V
L
Q
N
V
A
Site 32
Y376
R
R
G
M
F
E
P
Y
L
K
S
F
Y
I
R
Site 33
Y381
E
P
Y
L
K
S
F
Y
I
R
S
T
D
P
T
Site 34
S384
L
K
S
F
Y
I
R
S
T
D
P
T
Q
I
K
Site 35
T385
K
S
F
Y
I
R
S
T
D
P
T
Q
I
K
I
Site 36
T388
Y
I
R
S
T
D
P
T
Q
I
K
I
L
K
L
Site 37
T416
T
V
L
R
E
F
Q
T
Y
I
R
S
M
D
K
Site 38
Y417
V
L
R
E
F
Q
T
Y
I
R
S
M
D
K
D
Site 39
T438
Q
A
I
G
R
C
A
T
N
I
G
R
V
R
D
Site 40
T446
N
I
G
R
V
R
D
T
C
L
N
G
L
V
Q
Site 41
S529
V
L
R
K
M
A
K
S
F
T
A
E
E
D
I
Site 42
Y549
I
N
L
A
A
K
L
Y
L
T
N
S
K
Q
T
Site 43
T551
L
A
A
K
L
Y
L
T
N
S
K
Q
T
K
L
Site 44
S553
A
K
L
Y
L
T
N
S
K
Q
T
K
L
L
T
Site 45
T560
S
K
Q
T
K
L
L
T
Q
Y
V
L
S
L
A
Site 46
S565
L
L
T
Q
Y
V
L
S
L
A
K
Y
D
Q
N
Site 47
Y569
Y
V
L
S
L
A
K
Y
D
Q
N
Y
D
I
R
Site 48
Y573
L
A
K
Y
D
Q
N
Y
D
I
R
D
R
A
R
Site 49
T582
I
R
D
R
A
R
F
T
R
Q
L
I
V
P
S
Site 50
S596
S
E
Q
G
G
A
L
S
R
H
A
K
K
L
F
Site 51
S614
K
P
A
P
V
L
E
S
S
F
K
D
R
D
H
Site 52
S615
P
A
P
V
L
E
S
S
F
K
D
R
D
H
F
Site 53
S626
R
D
H
F
Q
L
G
S
L
S
H
L
L
N
A
Site 54
S652
P
E
E
A
P
D
P
S
V
R
N
V
E
V
P
Site 55
S665
V
P
E
W
T
K
C
S
N
R
E
K
R
K
E
Site 56
Y678
K
E
K
E
K
P
F
Y
S
D
S
E
G
E
S
Site 57
S679
E
K
E
K
P
F
Y
S
D
S
E
G
E
S
G
Site 58
S681
E
K
P
F
Y
S
D
S
E
G
E
S
G
P
T
Site 59
S685
Y
S
D
S
E
G
E
S
G
P
T
E
S
A
D
Site 60
T688
S
E
G
E
S
G
P
T
E
S
A
D
S
D
P
Site 61
S690
G
E
S
G
P
T
E
S
A
D
S
D
P
E
S
Site 62
S693
G
P
T
E
S
A
D
S
D
P
E
S
E
S
E
Site 63
S697
S
A
D
S
D
P
E
S
E
S
E
S
D
S
K
Site 64
S699
D
S
D
P
E
S
E
S
E
S
D
S
K
S
S
Site 65
S701
D
P
E
S
E
S
E
S
D
S
K
S
S
S
E
Site 66
S703
E
S
E
S
E
S
D
S
K
S
S
S
E
S
G
Site 67
S705
E
S
E
S
D
S
K
S
S
S
E
S
G
S
G
Site 68
S706
S
E
S
D
S
K
S
S
S
E
S
G
S
G
E
Site 69
S707
E
S
D
S
K
S
S
S
E
S
G
S
G
E
S
Site 70
S709
D
S
K
S
S
S
E
S
G
S
G
E
S
S
S
Site 71
S711
K
S
S
S
E
S
G
S
G
E
S
S
S
E
S
Site 72
S714
S
E
S
G
S
G
E
S
S
S
E
S
D
N
E
Site 73
S715
E
S
G
S
G
E
S
S
S
E
S
D
N
E
D
Site 74
S716
S
G
S
G
E
S
S
S
E
S
D
N
E
D
Q
Site 75
S718
S
G
E
S
S
S
E
S
D
N
E
D
Q
D
E
Site 76
S733
D
E
E
K
G
R
G
S
E
S
E
Q
S
E
E
Site 77
S735
E
K
G
R
G
S
E
S
E
Q
S
E
E
D
G
Site 78
S738
R
G
S
E
S
E
Q
S
E
E
D
G
K
R
K
Site 79
T746
E
E
D
G
K
R
K
T
K
K
K
V
P
E
R
Site 80
S758
P
E
R
K
G
E
A
S
S
S
D
E
G
S
D
Site 81
S759
E
R
K
G
E
A
S
S
S
D
E
G
S
D
S
Site 82
S760
R
K
G
E
A
S
S
S
D
E
G
S
D
S
S
Site 83
S764
A
S
S
S
D
E
G
S
D
S
S
S
S
S
S
Site 84
S766
S
S
D
E
G
S
D
S
S
S
S
S
S
E
S
Site 85
S767
S
D
E
G
S
D
S
S
S
S
S
S
E
S
E
Site 86
S768
D
E
G
S
D
S
S
S
S
S
S
E
S
E
M
Site 87
S769
E
G
S
D
S
S
S
S
S
S
E
S
E
M
T
Site 88
S770
G
S
D
S
S
S
S
S
S
E
S
E
M
T
S
Site 89
S771
S
D
S
S
S
S
S
S
E
S
E
M
T
S
E
Site 90
S773
S
S
S
S
S
S
E
S
E
M
T
S
E
S
E
Site 91
T776
S
S
S
E
S
E
M
T
S
E
S
E
E
E
Q
Site 92
S777
S
S
E
S
E
M
T
S
E
S
E
E
E
Q
L
Site 93
S779
E
S
E
M
T
S
E
S
E
E
E
Q
L
E
P
Site 94
S788
E
E
Q
L
E
P
A
S
W
S
R
K
T
P
P
Site 95
S790
Q
L
E
P
A
S
W
S
R
K
T
P
P
S
S
Site 96
T793
P
A
S
W
S
R
K
T
P
P
S
S
K
S
A
Site 97
S796
W
S
R
K
T
P
P
S
S
K
S
A
P
A
T
Site 98
S797
S
R
K
T
P
P
S
S
K
S
A
P
A
T
K
Site 99
S799
K
T
P
P
S
S
K
S
A
P
A
T
K
E
I
Site 100
T803
S
S
K
S
A
P
A
T
K
E
I
S
L
L
D
Site 101
S818
L
E
D
F
T
P
P
S
V
Q
P
V
S
P
P
Site 102
S855
P
S
L
L
S
P
V
S
G
V
G
R
Q
E
L
Site 103
Y875
G
E
G
L
A
V
D
Y
T
F
S
R
Q
P
F
Site 104
T876
E
G
L
A
V
D
Y
T
F
S
R
Q
P
F
S
Site 105
S878
L
A
V
D
Y
T
F
S
R
Q
P
F
S
G
D
Site 106
S883
T
F
S
R
Q
P
F
S
G
D
P
H
M
V
S
Site 107
S896
V
S
V
H
I
H
F
S
N
S
S
D
T
P
I
Site 108
T901
H
F
S
N
S
S
D
T
P
I
K
G
L
H
V
Site 109
S927
Q
E
F
P
E
I
E
S
L
A
P
G
E
S
A
Site 110
Y961
C
T
Q
T
R
Q
F
Y
V
S
I
Q
P
P
V
Site 111
S963
Q
T
R
Q
F
Y
V
S
I
Q
P
P
V
G
E
Site 112
T1004
E
K
L
M
L
P
D
T
C
R
S
D
H
I
V
Site 113
T1028
L
G
R
V
P
C
G
T
S
D
E
Y
R
F
A
Site 114
S1029
G
R
V
P
C
G
T
S
D
E
Y
R
F
A
G
Site 115
Y1032
P
C
G
T
S
D
E
Y
R
F
A
G
R
T
L
Site 116
T1038
E
Y
R
F
A
G
R
T
L
T
G
G
S
L
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation