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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDE3B
Full Name:
cGMP-inhibited 3',5'-cyclic phosphodiesterase B
Alias:
CGIP1; CGI-PDE B; CGIPDE1; Cyclic GMP inhibited phosphodiesterase B; Cyclic GMP-inhibited phosphodiesterase B; HcGIP1; Phosphodiesterase 3B; Phosphodiesterase 3B, cGMP-inhibited
Type:
EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase
Mass (Da):
124333
Number AA:
1112
UniProt ID:
Q13370
International Prot ID:
IPI00012843
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005783
GO:0032045
Uniprot
OncoNet
Molecular Function:
GO:0004119
GO:0043422
PhosphoSite+
KinaseNET
Biological Process:
GO:0006198
GO:0032869
GO:0043951
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
R
D
A
K
A
M
R
S
L
Q
P
P
D
G
A
Site 2
S22
Q
P
P
D
G
A
G
S
P
P
E
S
L
R
N
Site 3
S26
G
A
G
S
P
P
E
S
L
R
N
G
Y
V
K
Site 4
Y31
P
E
S
L
R
N
G
Y
V
K
S
C
V
S
P
Site 5
S34
L
R
N
G
Y
V
K
S
C
V
S
P
L
R
Q
Site 6
S37
G
Y
V
K
S
C
V
S
P
L
R
Q
D
P
P
Site 7
S65
E
L
R
P
P
P
A
S
P
Q
Q
P
R
R
C
Site 8
S73
P
Q
Q
P
R
R
C
S
P
F
C
R
A
R
L
Site 9
T139
L
T
C
F
L
T
R
T
K
R
G
P
G
P
G
Site 10
S148
R
G
P
G
P
G
R
S
C
G
S
W
W
L
L
Site 11
S183
W
G
D
G
D
A
G
S
A
A
P
H
T
P
P
Site 12
T188
A
G
S
A
A
P
H
T
P
P
E
A
A
A
G
Site 13
S279
A
P
L
H
P
R
L
S
S
A
A
E
E
K
V
Site 14
S280
P
L
H
P
R
L
S
S
A
A
E
E
K
V
P
Site 15
S295
V
I
R
P
R
R
R
S
S
C
V
S
L
G
E
Site 16
S296
I
R
P
R
R
R
S
S
C
V
S
L
G
E
T
Site 17
S299
R
R
R
S
S
C
V
S
L
G
E
T
A
A
S
Site 18
T303
S
C
V
S
L
G
E
T
A
A
S
Y
Y
G
S
Site 19
S306
S
L
G
E
T
A
A
S
Y
Y
G
S
C
K
I
Site 20
Y308
G
E
T
A
A
S
Y
Y
G
S
C
K
I
F
R
Site 21
S310
T
A
A
S
Y
Y
G
S
C
K
I
F
R
R
P
Site 22
S318
C
K
I
F
R
R
P
S
L
P
C
I
S
R
E
Site 23
S323
R
P
S
L
P
C
I
S
R
E
Q
M
I
L
W
Site 24
Y342
K
Q
W
Y
K
P
H
Y
Q
N
S
G
G
G
N
Site 25
S345
Y
K
P
H
Y
Q
N
S
G
G
G
N
G
V
D
Site 26
S354
G
G
N
G
V
D
L
S
V
L
N
E
A
R
N
Site 27
T368
N
M
V
S
D
L
L
T
D
P
S
L
P
P
Q
Site 28
S371
S
D
L
L
T
D
P
S
L
P
P
Q
V
I
S
Site 29
S378
S
L
P
P
Q
V
I
S
S
L
R
S
I
S
S
Site 30
S379
L
P
P
Q
V
I
S
S
L
R
S
I
S
S
L
Site 31
S391
S
S
L
M
G
A
F
S
G
S
C
R
P
K
I
Site 32
S393
L
M
G
A
F
S
G
S
C
R
P
K
I
N
P
Site 33
T402
R
P
K
I
N
P
L
T
P
F
P
G
F
Y
P
Site 34
Y408
L
T
P
F
P
G
F
Y
P
C
S
E
I
E
D
Site 35
S411
F
P
G
F
Y
P
C
S
E
I
E
D
P
A
E
Site 36
S432
N
K
G
L
N
R
N
S
L
P
T
P
Q
L
R
Site 37
T435
L
N
R
N
S
L
P
T
P
Q
L
R
R
S
S
Site 38
S441
P
T
P
Q
L
R
R
S
S
G
T
S
G
L
L
Site 39
S442
T
P
Q
L
R
R
S
S
G
T
S
G
L
L
P
Site 40
T444
Q
L
R
R
S
S
G
T
S
G
L
L
P
V
E
Site 41
S445
L
R
R
S
S
G
T
S
G
L
L
P
V
E
Q
Site 42
S453
G
L
L
P
V
E
Q
S
S
R
W
D
R
N
N
Site 43
Y476
G
I
S
S
Q
G
C
Y
L
N
G
P
F
N
S
Site 44
T487
P
F
N
S
N
L
L
T
I
P
K
Q
R
S
S
Site 45
S493
L
T
I
P
K
Q
R
S
S
S
V
S
L
T
H
Site 46
S494
T
I
P
K
Q
R
S
S
S
V
S
L
T
H
H
Site 47
S495
I
P
K
Q
R
S
S
S
V
S
L
T
H
H
V
Site 48
S497
K
Q
R
S
S
S
V
S
L
T
H
H
V
G
L
Site 49
T499
R
S
S
S
V
S
L
T
H
H
V
G
L
R
R
Site 50
S512
R
R
A
G
V
L
S
S
L
S
P
V
N
S
S
Site 51
S514
A
G
V
L
S
S
L
S
P
V
N
S
S
N
H
Site 52
S518
S
S
L
S
P
V
N
S
S
N
H
G
P
V
S
Site 53
S519
S
L
S
P
V
N
S
S
N
H
G
P
V
S
T
Site 54
S525
S
S
N
H
G
P
V
S
T
G
S
L
T
N
R
Site 55
S528
H
G
P
V
S
T
G
S
L
T
N
R
S
P
I
Site 56
T530
P
V
S
T
G
S
L
T
N
R
S
P
I
E
F
Site 57
S533
T
G
S
L
T
N
R
S
P
I
E
F
P
D
T
Site 58
T540
S
P
I
E
F
P
D
T
A
D
F
L
N
K
P
Site 59
S554
P
S
V
I
L
Q
R
S
L
G
N
A
P
N
T
Site 60
T561
S
L
G
N
A
P
N
T
P
D
F
Y
Q
Q
L
Site 61
Y565
A
P
N
T
P
D
F
Y
Q
Q
L
R
N
S
D
Site 62
S571
F
Y
Q
Q
L
R
N
S
D
S
N
L
C
N
S
Site 63
S573
Q
Q
L
R
N
S
D
S
N
L
C
N
S
C
G
Site 64
Y586
C
G
H
Q
M
L
K
Y
V
S
T
S
E
S
D
Site 65
S588
H
Q
M
L
K
Y
V
S
T
S
E
S
D
G
T
Site 66
S590
M
L
K
Y
V
S
T
S
E
S
D
G
T
D
C
Site 67
S592
K
Y
V
S
T
S
E
S
D
G
T
D
C
C
S
Site 68
T595
S
T
S
E
S
D
G
T
D
C
C
S
G
K
S
Site 69
S599
S
D
G
T
D
C
C
S
G
K
S
G
E
E
E
Site 70
S602
T
D
C
C
S
G
K
S
G
E
E
E
N
I
F
Site 71
S610
G
E
E
E
N
I
F
S
K
E
S
F
K
L
M
Site 72
S613
E
N
I
F
S
K
E
S
F
K
L
M
E
T
Q
Site 73
T625
E
T
Q
Q
E
E
E
T
E
K
K
D
S
R
K
Site 74
S630
E
E
T
E
K
K
D
S
R
K
L
F
Q
E
G
Site 75
S669
I
L
V
E
E
Y
D
S
L
I
E
K
M
S
N
Site 76
S692
V
E
K
M
G
E
K
S
G
R
I
L
S
Q
V
Site 77
S697
E
K
S
G
R
I
L
S
Q
V
M
Y
T
L
F
Site 78
Y723
P
T
Q
Q
F
M
N
Y
F
R
A
L
E
N
G
Site 79
Y736
N
G
Y
R
D
I
P
Y
H
N
R
I
H
A
T
Site 80
Y751
D
V
L
H
A
V
W
Y
L
T
T
R
P
V
P
Site 81
T769
Q
I
H
N
G
C
G
T
G
N
E
T
D
S
D
Site 82
T773
G
C
G
T
G
N
E
T
D
S
D
G
R
I
N
Site 83
S775
G
T
G
N
E
T
D
S
D
G
R
I
N
H
G
Site 84
Y786
I
N
H
G
R
I
A
Y
I
S
S
K
S
C
S
Site 85
S788
H
G
R
I
A
Y
I
S
S
K
S
C
S
N
P
Site 86
S789
G
R
I
A
Y
I
S
S
K
S
C
S
N
P
D
Site 87
S791
I
A
Y
I
S
S
K
S
C
S
N
P
D
E
S
Site 88
S793
Y
I
S
S
K
S
C
S
N
P
D
E
S
Y
G
Site 89
S798
S
C
S
N
P
D
E
S
Y
G
C
L
S
S
N
Site 90
Y799
C
S
N
P
D
E
S
Y
G
C
L
S
S
N
I
Site 91
Y823
V
A
A
A
M
H
D
Y
D
H
P
G
R
T
N
Site 92
Y844
N
A
P
Q
A
V
L
Y
N
D
R
S
V
L
E
Site 93
S848
A
V
L
Y
N
D
R
S
V
L
E
N
H
H
A
Site 94
Y862
A
A
S
A
W
N
L
Y
L
S
R
P
E
Y
N
Site 95
S864
S
A
W
N
L
Y
L
S
R
P
E
Y
N
F
L
Site 96
Y868
L
Y
L
S
R
P
E
Y
N
F
L
L
H
L
D
Site 97
S914
A
K
A
N
D
V
N
S
N
G
I
E
W
S
N
Site 98
S920
N
S
N
G
I
E
W
S
N
E
N
D
R
L
L
Site 99
Y960
E
G
I
V
N
E
F
Y
E
Q
G
D
E
E
A
Site 100
S974
A
N
L
G
L
P
I
S
P
F
M
D
R
S
S
Site 101
S980
I
S
P
F
M
D
R
S
S
P
Q
L
A
K
L
Site 102
S981
S
P
F
M
D
R
S
S
P
Q
L
A
K
L
Q
Site 103
T1022
E
A
E
E
D
N
D
T
E
S
G
D
D
E
D
Site 104
S1024
E
E
D
N
D
T
E
S
G
D
D
E
D
G
E
Site 105
T1035
E
D
G
E
E
L
D
T
E
D
E
E
M
E
N
Site 106
S1053
P
K
P
P
R
R
K
S
R
R
R
I
F
C
Q
Site 107
S1094
N
K
L
Q
V
E
N
S
S
L
P
Q
A
D
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation