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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MAPK8IP2
Full Name:
C-Jun-amino-terminal kinase-interacting protein 2
Alias:
IB2; IB-2; Islet-brain-2; JIP2; JIP-2; JNK MAP kinase scaffold 2
Type:
Protein kinase interacting protein; Cell soma, cytoplasm protein
Mass (Da):
87975
Number AA:
824
UniProt ID:
Q13387
International Prot ID:
IPI00031777
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005078
GO:0001540
GO:0019894
PhosphoSite+
KinaseNET
Biological Process:
GO:0045768
GO:0046328
GO:0007172
Phosida
TranscriptoNet
STRING
Kinexus Products
C-Jun-amino-terminal kinase-interacting protein 2 pan-specific antibody AB-NN272-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN272-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
A
D
R
A
E
M
F
S
L
S
T
F
H
S
L
Site 2
S11
R
A
E
M
F
S
L
S
T
F
H
S
L
S
P
Site 3
T12
A
E
M
F
S
L
S
T
F
H
S
L
S
P
P
Site 4
S15
F
S
L
S
T
F
H
S
L
S
P
P
G
C
R
Site 5
S17
L
S
T
F
H
S
L
S
P
P
G
C
R
P
P
Site 6
S28
C
R
P
P
Q
D
I
S
L
E
E
F
D
D
E
Site 7
S38
E
F
D
D
E
D
L
S
E
I
T
D
D
C
G
Site 8
S49
D
D
C
G
L
G
L
S
Y
D
S
D
H
C
E
Site 9
Y50
D
C
G
L
G
L
S
Y
D
S
D
H
C
E
K
Site 10
S52
G
L
G
L
S
Y
D
S
D
H
C
E
K
D
S
Site 11
S59
S
D
H
C
E
K
D
S
L
S
L
G
R
S
E
Site 12
S61
H
C
E
K
D
S
L
S
L
G
R
S
E
Q
P
Site 13
S65
D
S
L
S
L
G
R
S
E
Q
P
H
P
I
C
Site 14
S116
Q
E
G
G
D
P
G
S
E
A
P
A
P
G
P
Site 15
S127
A
P
G
P
L
I
P
S
P
S
V
E
E
P
H
Site 16
S129
G
P
L
I
P
S
P
S
V
E
E
P
H
K
H
Site 17
T139
E
P
H
K
H
R
P
T
T
L
R
L
T
T
L
Site 18
T140
P
H
K
H
R
P
T
T
L
R
L
T
T
L
G
Site 19
T144
R
P
T
T
L
R
L
T
T
L
G
A
Q
D
S
Site 20
T145
P
T
T
L
R
L
T
T
L
G
A
Q
D
S
L
Site 21
S151
T
T
L
G
A
Q
D
S
L
N
N
N
G
G
F
Site 22
T169
R
P
A
S
W
Q
E
T
A
L
C
S
P
A
P
Site 23
S173
W
Q
E
T
A
L
C
S
P
A
P
E
A
L
R
Site 24
T189
L
P
G
P
L
P
A
T
D
T
G
P
G
G
A
Site 25
T191
G
P
L
P
A
T
D
T
G
P
G
G
A
Q
S
Site 26
S198
T
G
P
G
G
A
Q
S
P
V
R
P
G
C
D
Site 27
S221
P
P
A
P
G
G
T
S
P
S
S
D
P
G
I
Site 28
S223
A
P
G
G
T
S
P
S
S
D
P
G
I
E
A
Site 29
S224
P
G
G
T
S
P
S
S
D
P
G
I
E
A
D
Site 30
S234
G
I
E
A
D
L
R
S
R
S
S
G
G
R
G
Site 31
S236
E
A
D
L
R
S
R
S
S
G
G
R
G
G
R
Site 32
S237
A
D
L
R
S
R
S
S
G
G
R
G
G
R
R
Site 33
S245
G
G
R
G
G
R
R
S
S
Q
E
L
S
S
P
Site 34
S246
G
R
G
G
R
R
S
S
Q
E
L
S
S
P
G
Site 35
S250
R
R
S
S
Q
E
L
S
S
P
G
S
D
S
E
Site 36
S251
R
S
S
Q
E
L
S
S
P
G
S
D
S
E
D
Site 37
S254
Q
E
L
S
S
P
G
S
D
S
E
D
A
G
G
Site 38
S256
L
S
S
P
G
S
D
S
E
D
A
G
G
A
R
Site 39
S269
A
R
L
G
R
M
I
S
S
I
S
E
T
E
L
Site 40
S270
R
L
G
R
M
I
S
S
I
S
E
T
E
L
E
Site 41
S272
G
R
M
I
S
S
I
S
E
T
E
L
E
L
S
Site 42
T274
M
I
S
S
I
S
E
T
E
L
E
L
S
S
D
Site 43
S279
S
E
T
E
L
E
L
S
S
D
G
G
S
S
S
Site 44
S280
E
T
E
L
E
L
S
S
D
G
G
S
S
S
S
Site 45
S284
E
L
S
S
D
G
G
S
S
S
S
G
R
S
S
Site 46
S285
L
S
S
D
G
G
S
S
S
S
G
R
S
S
H
Site 47
S286
S
S
D
G
G
S
S
S
S
G
R
S
S
H
L
Site 48
S287
S
D
G
G
S
S
S
S
G
R
S
S
H
L
T
Site 49
S290
G
S
S
S
S
G
R
S
S
H
L
T
N
S
I
Site 50
S291
S
S
S
S
G
R
S
S
H
L
T
N
S
I
E
Site 51
T294
S
G
R
S
S
H
L
T
N
S
I
E
E
A
S
Site 52
S296
R
S
S
H
L
T
N
S
I
E
E
A
S
S
P
Site 53
S302
N
S
I
E
E
A
S
S
P
A
S
E
P
E
P
Site 54
S305
E
E
A
S
S
P
A
S
E
P
E
P
P
R
E
Site 55
T327
L
P
V
G
P
D
D
T
N
S
E
Y
E
S
G
Site 56
S329
V
G
P
D
D
T
N
S
E
Y
E
S
G
S
E
Site 57
Y331
P
D
D
T
N
S
E
Y
E
S
G
S
E
S
E
Site 58
S333
D
T
N
S
E
Y
E
S
G
S
E
S
E
P
D
Site 59
S335
N
S
E
Y
E
S
G
S
E
S
E
P
D
L
S
Site 60
S337
E
Y
E
S
G
S
E
S
E
P
D
L
S
E
D
Site 61
S342
S
E
S
E
P
D
L
S
E
D
A
D
S
P
W
Site 62
S347
D
L
S
E
D
A
D
S
P
W
L
L
S
N
L
Site 63
S360
N
L
V
S
R
M
I
S
E
G
S
S
P
I
R
Site 64
S363
S
R
M
I
S
E
G
S
S
P
I
R
C
P
G
Site 65
S364
R
M
I
S
E
G
S
S
P
I
R
C
P
G
Q
Site 66
S374
R
C
P
G
Q
C
L
S
P
A
P
R
P
P
G
Site 67
S385
R
P
P
G
E
P
V
S
P
A
G
G
A
A
Q
Site 68
S394
A
G
G
A
A
Q
D
S
Q
D
P
E
A
A
A
Site 69
T413
V
E
L
V
D
M
E
T
L
C
A
P
P
P
P
Site 70
S439
P
G
P
C
L
F
L
S
N
P
T
R
D
T
I
Site 71
T445
L
S
N
P
T
R
D
T
I
T
P
L
W
A
A
Site 72
T447
N
P
T
R
D
T
I
T
P
L
W
A
A
P
G
Site 73
S464
A
R
P
G
R
A
C
S
A
A
C
S
E
E
E
Site 74
S468
R
A
C
S
A
A
C
S
E
E
E
D
E
E
D
Site 75
S485
E
E
E
D
A
E
D
S
A
G
S
P
G
G
R
Site 76
S488
D
A
E
D
S
A
G
S
P
G
G
R
G
T
G
Site 77
T494
G
S
P
G
G
R
G
T
G
P
S
A
P
R
D
Site 78
S497
G
G
R
G
T
G
P
S
A
P
R
D
A
S
L
Site 79
S503
P
S
A
P
R
D
A
S
L
V
Y
D
A
V
K
Site 80
Y506
P
R
D
A
S
L
V
Y
D
A
V
K
Y
T
L
Site 81
S536
C
A
G
L
G
H
D
S
E
E
D
S
G
G
E
Site 82
S540
G
H
D
S
E
E
D
S
G
G
E
A
S
E
E
Site 83
S560
L
L
G
G
G
Q
V
S
G
D
T
S
P
D
S
Site 84
T563
G
G
Q
V
S
G
D
T
S
P
D
S
P
D
L
Site 85
S564
G
Q
V
S
G
D
T
S
P
D
S
P
D
L
T
Site 86
S567
S
G
D
T
S
P
D
S
P
D
L
T
F
S
K
Site 87
T571
S
P
D
S
P
D
L
T
F
S
K
K
F
L
N
Site 88
S583
F
L
N
V
F
V
N
S
T
S
R
S
S
S
T
Site 89
T584
L
N
V
F
V
N
S
T
S
R
S
S
S
T
E
Site 90
S585
N
V
F
V
N
S
T
S
R
S
S
S
T
E
S
Site 91
S587
F
V
N
S
T
S
R
S
S
S
T
E
S
F
G
Site 92
S588
V
N
S
T
S
R
S
S
S
T
E
S
F
G
L
Site 93
S589
N
S
T
S
R
S
S
S
T
E
S
F
G
L
F
Site 94
T590
S
T
S
R
S
S
S
T
E
S
F
G
L
F
S
Site 95
S592
S
R
S
S
S
T
E
S
F
G
L
F
S
C
L
Site 96
T608
N
G
E
E
R
E
Q
T
H
R
A
V
F
R
F
Site 97
S673
P
A
K
D
L
L
G
S
K
R
S
P
C
W
V
Site 98
S676
D
L
L
G
S
K
R
S
P
C
W
V
E
R
F
Site 99
S737
S
L
R
G
V
K
L
S
L
S
G
G
G
P
E
Site 100
S739
R
G
V
K
L
S
L
S
G
G
G
P
E
F
Q
Site 101
S799
S
M
R
P
V
A
Q
S
V
G
R
A
F
L
E
Site 102
Y807
V
G
R
A
F
L
E
Y
Y
Q
E
H
L
A
Y
Site 103
Y808
G
R
A
F
L
E
Y
Y
Q
E
H
L
A
Y
A
Site 104
Y814
Y
Y
Q
E
H
L
A
Y
A
C
P
T
E
D
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation