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Updated November 2019
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Protein Info
Short Name:
MYO7A
Full Name:
Myosin-VIIa
Alias:
DFNA11; DFNB2; MY7A; MYO7; Myosin VIIa; NSRD2; USH1B
Type:
Motor protein
Mass (Da):
254406
Number AA:
2215
UniProt ID:
Q13402
International Prot ID:
IPI00013193
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005765
GO:0016459
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003779
GO:0005516
PhosphoSite+
KinaseNET
Biological Process:
GO:0030048
GO:0050957
GO:0042462
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y95
R
Y
R
D
H
L
I
Y
T
Y
T
G
S
I
L
Site 2
S112
V
N
P
Y
Q
L
L
S
I
Y
S
P
E
H
I
Site 3
S115
Y
Q
L
L
S
I
Y
S
P
E
H
I
R
Q
Y
Site 4
Y122
S
P
E
H
I
R
Q
Y
T
N
K
K
I
G
E
Site 5
T123
P
E
H
I
R
Q
Y
T
N
K
K
I
G
E
M
Site 6
Y142
F
A
I
A
D
N
C
Y
F
N
M
K
R
N
S
Site 7
S157
R
D
Q
C
C
I
I
S
G
E
S
G
A
G
K
Site 8
T165
G
E
S
G
A
G
K
T
E
S
T
K
L
I
L
Site 9
S167
S
G
A
G
K
T
E
S
T
K
L
I
L
Q
F
Site 10
S183
A
A
I
S
G
Q
H
S
W
I
E
Q
Q
V
L
Site 11
T204
E
A
F
G
N
A
K
T
I
R
N
D
N
S
S
Site 12
S210
K
T
I
R
N
D
N
S
S
R
F
G
K
Y
I
Site 13
S211
T
I
R
N
D
N
S
S
R
F
G
K
Y
I
D
Site 14
Y216
N
S
S
R
F
G
K
Y
I
D
I
H
F
N
K
Site 15
Y235
E
G
A
K
I
E
Q
Y
L
L
E
K
S
R
V
Site 16
Y252
Q
A
L
D
E
R
N
Y
H
V
F
Y
C
M
L
Site 17
Y256
E
R
N
Y
H
V
F
Y
C
M
L
E
G
M
S
Site 18
Y278
G
L
G
Q
A
S
D
Y
N
Y
L
A
M
G
N
Site 19
Y280
G
Q
A
S
D
Y
N
Y
L
A
M
G
N
C
I
Site 20
S295
T
C
E
G
R
V
D
S
Q
E
Y
A
N
I
R
Site 21
Y298
G
R
V
D
S
Q
E
Y
A
N
I
R
S
A
M
Site 22
T313
K
V
L
M
F
T
D
T
E
N
W
E
I
S
K
Site 23
Y333
L
H
L
G
N
L
Q
Y
E
A
R
T
F
E
N
Site 24
T381
T
L
I
T
R
G
E
T
V
S
T
P
L
S
R
Site 25
S383
I
T
R
G
E
T
V
S
T
P
L
S
R
E
Q
Site 26
T384
T
R
G
E
T
V
S
T
P
L
S
R
E
Q
A
Site 27
S387
E
T
V
S
T
P
L
S
R
E
Q
A
L
D
V
Site 28
Y419
D
K
I
N
A
A
I
Y
K
P
P
S
Q
D
V
Site 29
S423
A
A
I
Y
K
P
P
S
Q
D
V
K
N
S
R
Site 30
S429
P
S
Q
D
V
K
N
S
R
R
S
I
G
L
L
Site 31
S432
D
V
K
N
S
R
R
S
I
G
L
L
D
I
F
Site 32
Y477
F
K
L
E
Q
E
E
Y
D
L
E
S
I
D
W
Site 33
S508
N
K
P
M
N
I
I
S
L
I
D
E
E
S
K
Site 34
S514
I
S
L
I
D
E
E
S
K
F
P
K
G
T
D
Site 35
T522
K
F
P
K
G
T
D
T
T
M
L
H
K
L
N
Site 36
S530
T
M
L
H
K
L
N
S
Q
H
K
L
N
A
N
Site 37
Y538
Q
H
K
L
N
A
N
Y
I
P
P
K
N
N
H
Site 38
T572
F
L
E
K
N
R
D
T
L
H
G
D
I
I
Q
Site 39
S583
D
I
I
Q
L
V
H
S
S
R
N
K
F
I
K
Site 40
S584
I
I
Q
L
V
H
S
S
R
N
K
F
I
K
Q
Site 41
T603
D
V
A
M
G
A
E
T
R
K
R
S
P
T
L
Site 42
S607
G
A
E
T
R
K
R
S
P
T
L
S
S
Q
F
Site 43
T609
E
T
R
K
R
S
P
T
L
S
S
Q
F
K
R
Site 44
S611
R
K
R
S
P
T
L
S
S
Q
F
K
R
S
L
Site 45
S612
K
R
S
P
T
L
S
S
Q
F
K
R
S
L
E
Site 46
S617
L
S
S
Q
F
K
R
S
L
E
L
L
M
R
T
Site 47
T664
R
Y
S
G
M
M
E
T
I
R
I
R
R
A
G
Site 48
Y672
I
R
I
R
R
A
G
Y
P
I
R
Y
S
F
V
Site 49
S677
A
G
Y
P
I
R
Y
S
F
V
E
F
V
E
R
Site 50
Y696
L
P
G
V
K
P
A
Y
K
Q
G
D
L
R
G
Site 51
T704
K
Q
G
D
L
R
G
T
C
Q
R
M
A
E
A
Site 52
T745
V
E
R
D
K
A
I
T
D
R
V
I
L
L
Q
Site 53
S762
I
R
G
F
K
D
R
S
N
F
L
K
L
K
N
Site 54
T772
L
K
L
K
N
A
A
T
L
I
Q
R
H
W
R
Site 55
Y787
G
H
N
C
R
K
N
Y
G
L
M
R
L
G
F
Site 56
Y827
F
Q
A
R
C
R
A
Y
L
V
R
K
A
F
R
Site 57
Y863
H
Q
R
L
R
A
E
Y
L
W
R
L
E
A
E
Site 58
S885
E
K
L
R
K
E
M
S
A
K
K
A
K
E
E
Site 59
S997
D
E
D
E
E
D
L
S
E
Y
K
F
A
K
F
Site 60
Y1008
F
A
K
F
A
A
T
Y
F
Q
G
T
T
T
H
Site 61
S1016
F
Q
G
T
T
T
H
S
Y
T
R
R
P
L
K
Site 62
Y1017
Q
G
T
T
T
H
S
Y
T
R
R
P
L
K
Q
Site 63
Y1028
P
L
K
Q
P
L
L
Y
H
D
D
E
G
D
Q
Site 64
Y1057
G
D
L
P
E
P
K
Y
H
T
A
M
S
D
G
Site 65
S1062
P
K
Y
H
T
A
M
S
D
G
S
E
K
I
P
Site 66
Y1075
I
P
V
M
T
K
I
Y
E
T
L
G
K
K
T
Site 67
Y1083
E
T
L
G
K
K
T
Y
K
R
E
L
Q
A
L
Site 68
S1105
L
P
E
G
Q
K
K
S
S
V
R
H
K
L
V
Site 69
S1106
P
E
G
Q
K
K
S
S
V
R
H
K
L
V
H
Site 70
T1115
R
H
K
L
V
H
L
T
L
K
K
K
S
K
L
Site 71
T1127
S
K
L
T
E
E
V
T
K
R
L
H
D
G
E
Site 72
S1135
K
R
L
H
D
G
E
S
T
V
Q
G
N
S
M
Site 73
T1136
R
L
H
D
G
E
S
T
V
Q
G
N
S
M
L
Site 74
T1148
S
M
L
E
D
R
P
T
S
N
L
E
K
L
H
Site 75
S1149
M
L
E
D
R
P
T
S
N
L
E
K
L
H
F
Site 76
Y1172
P
A
L
R
D
E
I
Y
C
Q
I
S
K
Q
L
Site 77
T1180
C
Q
I
S
K
Q
L
T
H
N
P
S
K
S
S
Site 78
S1184
K
Q
L
T
H
N
P
S
K
S
S
Y
A
R
G
Site 79
S1186
L
T
H
N
P
S
K
S
S
Y
A
R
G
W
I
Site 80
Y1188
H
N
P
S
K
S
S
Y
A
R
G
W
I
L
V
Site 81
Y1211
P
S
E
K
F
V
K
Y
L
R
N
F
I
H
G
Site 82
Y1223
I
H
G
G
P
P
G
Y
A
P
Y
C
E
E
R
Site 83
Y1226
G
P
P
G
Y
A
P
Y
C
E
E
R
L
R
R
Site 84
T1234
C
E
E
R
L
R
R
T
F
V
N
G
T
R
T
Site 85
T1241
T
F
V
N
G
T
R
T
Q
P
P
S
W
L
E
Site 86
S1245
G
T
R
T
Q
P
P
S
W
L
E
L
Q
A
T
Site 87
T1252
S
W
L
E
L
Q
A
T
K
S
K
K
P
I
M
Site 88
S1254
L
E
L
Q
A
T
K
S
K
K
P
I
M
L
P
Site 89
T1271
F
M
D
G
T
T
K
T
L
L
T
D
S
A
T
Site 90
T1274
G
T
T
K
T
L
L
T
D
S
A
T
T
A
K
Site 91
S1276
T
K
T
L
L
T
D
S
A
T
T
A
K
E
L
Site 92
T1278
T
L
L
T
D
S
A
T
T
A
K
E
L
C
N
Site 93
S1292
N
A
L
A
D
K
I
S
L
K
D
R
F
G
F
Site 94
S1311
A
L
F
D
K
V
S
S
L
G
S
G
S
D
H
Site 95
S1314
D
K
V
S
S
L
G
S
G
S
D
H
V
M
D
Site 96
T1352
F
F
R
K
E
V
F
T
P
W
H
S
P
S
E
Site 97
S1356
E
V
F
T
P
W
H
S
P
S
E
D
N
V
A
Site 98
S1358
F
T
P
W
H
S
P
S
E
D
N
V
A
T
N
Site 99
Y1380
R
G
V
K
F
G
E
Y
R
C
E
K
E
D
D
Site 100
S1393
D
D
L
A
E
L
A
S
Q
Q
Y
F
V
D
Y
Site 101
Y1396
A
E
L
A
S
Q
Q
Y
F
V
D
Y
G
S
E
Site 102
Y1400
S
Q
Q
Y
F
V
D
Y
G
S
E
M
I
L
E
Site 103
S1402
Q
Y
F
V
D
Y
G
S
E
M
I
L
E
R
L
Site 104
T1423
Y
I
P
D
R
E
I
T
P
L
K
T
L
E
K
Site 105
T1427
R
E
I
T
P
L
K
T
L
E
K
W
A
Q
L
Site 106
T1449
G
I
Y
A
Q
R
R
T
D
A
Q
K
V
K
E
Site 107
S1460
K
V
K
E
D
V
V
S
Y
A
R
F
K
W
P
Site 108
Y1461
V
K
E
D
V
V
S
Y
A
R
F
K
W
P
L
Site 109
Y1474
P
L
L
F
S
R
F
Y
E
A
Y
K
F
S
G
Site 110
Y1477
F
S
R
F
Y
E
A
Y
K
F
S
G
P
S
L
Site 111
S1483
A
Y
K
F
S
G
P
S
L
P
K
N
D
V
I
Site 112
Y1499
A
V
N
W
T
G
V
Y
F
V
D
E
Q
E
Q
Site 113
S1520
F
P
E
I
M
A
V
S
S
S
R
E
C
R
V
Site 114
S1521
P
E
I
M
A
V
S
S
S
R
E
C
R
V
W
Site 115
S1530
R
E
C
R
V
W
L
S
L
G
C
S
D
L
G
Site 116
T1549
H
S
G
W
A
G
L
T
P
A
G
P
C
S
P
Site 117
S1555
L
T
P
A
G
P
C
S
P
C
W
S
C
R
G
Site 118
T1565
W
S
C
R
G
A
K
T
T
A
P
S
F
T
L
Site 119
T1566
S
C
R
G
A
K
T
T
A
P
S
F
T
L
A
Site 120
S1569
G
A
K
T
T
A
P
S
F
T
L
A
T
I
K
Site 121
T1571
K
T
T
A
P
S
F
T
L
A
T
I
K
G
D
Site 122
Y1580
A
T
I
K
G
D
E
Y
T
F
T
S
S
N
A
Site 123
T1581
T
I
K
G
D
E
Y
T
F
T
S
S
N
A
E
Site 124
T1583
K
G
D
E
Y
T
F
T
S
S
N
A
E
D
I
Site 125
S1605
L
E
G
L
R
K
R
S
K
Y
V
V
A
L
Q
Site 126
Y1607
G
L
R
K
R
S
K
Y
V
V
A
L
Q
D
N
Site 127
S1622
P
N
P
A
G
E
E
S
G
F
L
S
F
A
K
Site 128
T1639
L
I
I
L
D
H
D
T
G
E
Q
V
M
N
S
Site 129
T1672
D
C
V
Y
V
M
P
T
V
T
M
P
P
R
E
Site 130
T1687
I
V
A
L
V
T
M
T
P
D
Q
R
Q
D
V
Site 131
T1702
V
R
L
L
Q
L
R
T
A
E
P
E
V
R
A
Site 132
T1713
E
V
R
A
K
P
Y
T
L
E
E
F
S
Y
D
Site 133
Y1719
Y
T
L
E
E
F
S
Y
D
Y
F
R
P
P
P
Site 134
Y1721
L
E
E
F
S
Y
D
Y
F
R
P
P
P
K
H
Site 135
T1729
F
R
P
P
P
K
H
T
L
S
R
V
M
V
S
Site 136
S1731
P
P
P
K
H
T
L
S
R
V
M
V
S
K
A
Site 137
S1746
R
G
K
D
R
L
W
S
H
T
R
E
P
L
K
Site 138
T1748
K
D
R
L
W
S
H
T
R
E
P
L
K
Q
A
Site 139
S1763
L
L
K
K
L
L
G
S
E
E
L
S
Q
E
A
Site 140
Y1784
V
L
K
Y
M
G
D
Y
P
S
K
R
T
R
S
Site 141
S1786
K
Y
M
G
D
Y
P
S
K
R
T
R
S
V
N
Site 142
S1791
Y
P
S
K
R
T
R
S
V
N
E
L
T
D
Q
Site 143
Y1814
E
P
L
K
D
E
A
Y
V
Q
I
L
K
Q
L
Site 144
Y1828
L
T
D
N
H
I
R
Y
S
E
E
R
G
W
E
Site 145
S1829
T
D
N
H
I
R
Y
S
E
E
R
G
W
E
L
Site 146
S1882
Q
K
A
L
R
N
G
S
R
K
Y
P
P
H
L
Site 147
Y1885
L
R
N
G
S
R
K
Y
P
P
H
L
V
E
V
Site 148
Y1907
T
Q
I
F
H
K
V
Y
F
P
D
D
T
D
E
Site 149
T1912
K
V
Y
F
P
D
D
T
D
E
A
F
E
V
E
Site 150
S1921
E
A
F
E
V
E
S
S
T
K
A
K
D
F
C
Site 151
T2001
M
K
K
L
W
T
T
T
V
P
G
K
D
P
M
Site 152
Y2015
M
A
D
S
I
F
H
Y
Y
Q
E
L
P
K
Y
Site 153
Y2016
A
D
S
I
F
H
Y
Y
Q
E
L
P
K
Y
L
Site 154
Y2022
Y
Y
Q
E
L
P
K
Y
L
R
G
Y
H
K
C
Site 155
Y2026
L
P
K
Y
L
R
G
Y
H
K
C
T
R
E
E
Site 156
S2051
V
K
F
E
E
D
K
S
Y
F
P
S
I
P
K
Site 157
Y2052
K
F
E
E
D
K
S
Y
F
P
S
I
P
K
L
Site 158
S2055
E
D
K
S
Y
F
P
S
I
P
K
L
L
R
E
Site 159
S2073
Q
D
L
I
R
Q
V
S
P
D
D
W
K
R
S
Site 160
Y2084
W
K
R
S
I
V
A
Y
F
N
K
H
A
G
K
Site 161
T2120
A
F
F
E
V
K
Q
T
T
E
P
N
F
P
E
Site 162
Y2136
L
L
I
A
I
N
K
Y
G
V
S
L
I
D
P
Site 163
S2139
A
I
N
K
Y
G
V
S
L
I
D
P
K
T
K
Site 164
T2145
V
S
L
I
D
P
K
T
K
D
I
L
T
T
H
Site 165
T2150
P
K
T
K
D
I
L
T
T
H
P
F
T
K
I
Site 166
Y2166
N
W
S
S
G
N
T
Y
F
H
I
T
I
G
N
Site 167
S2185
S
K
L
L
C
E
T
S
L
G
Y
K
M
D
D
Site 168
T2195
Y
K
M
D
D
L
L
T
S
Y
I
S
Q
M
L
Site 169
S2196
K
M
D
D
L
L
T
S
Y
I
S
Q
M
L
T
Site 170
T2203
S
Y
I
S
Q
M
L
T
A
M
S
K
Q
R
G
Site 171
S2206
S
Q
M
L
T
A
M
S
K
Q
R
G
S
R
S
Site 172
S2211
A
M
S
K
Q
R
G
S
R
S
G
K
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation