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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DYNC1I2
Full Name:
Cytoplasmic dynein 1 intermediate chain 2
Alias:
Cytoplasmic dynein intermediate chain 2; DC1I2; DH IC-2; DNCI2; DNCIC2; Dynein intermediate chain 2, cytosolic; Dynein, cytoplasmic 1, intermediate chain 2
Type:
Motor protein
Mass (Da):
71457
Number AA:
638
UniProt ID:
Q13409
International Prot ID:
IPI00744015
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0003777
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007018
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
S
D
K
S
E
L
K
A
E
L
E
Site 2
T37
E
E
R
K
K
K
E
T
D
Q
K
K
E
A
V
Site 3
S51
V
A
P
V
Q
E
E
S
D
L
E
K
K
R
R
Site 4
S66
E
A
E
A
L
L
Q
S
M
G
L
T
P
E
S
Site 5
T70
L
L
Q
S
M
G
L
T
P
E
S
P
I
V
P
Site 6
S73
S
M
G
L
T
P
E
S
P
I
V
P
P
P
M
Site 7
S78
P
E
S
P
I
V
F
S
E
Y
W
V
P
P
P
Site 8
S87
Y
W
V
P
P
P
M
S
P
S
S
K
S
V
S
Site 9
S89
V
P
P
P
M
S
P
S
S
K
S
V
S
T
P
Site 10
S90
P
P
P
M
S
P
S
S
K
S
V
S
T
P
S
Site 11
S92
P
M
S
P
S
S
K
S
V
S
T
P
S
E
A
Site 12
S94
S
P
S
S
K
S
V
S
T
P
S
E
A
G
S
Site 13
T95
P
S
S
K
S
V
S
T
P
S
E
A
G
S
Q
Site 14
S97
S
P
S
S
K
S
V
S
T
P
S
E
A
G
S
Site 15
S101
S
T
P
S
E
A
G
S
Q
D
S
G
D
G
A
Site 16
S104
S
T
P
S
E
A
G
S
Q
D
S
G
D
G
A
Site 17
S111
S
G
D
G
A
V
G
S
R
T
L
H
W
D
T
Site 18
T113
D
G
A
V
G
S
R
T
L
H
W
D
T
D
P
Site 19
T118
S
R
T
L
H
W
D
T
D
P
S
V
L
Q
L
Site 20
S121
L
H
W
D
T
D
P
S
V
L
Q
L
H
S
D
Site 21
S127
P
S
V
L
Q
L
H
S
D
S
D
L
G
R
G
Site 22
S129
V
L
Q
L
H
S
D
S
D
L
G
R
G
P
I
Site 23
T144
K
L
G
M
A
K
I
T
Q
V
D
F
P
P
R
Site 24
Y156
P
P
R
E
I
V
T
Y
T
K
E
T
Q
T
P
Site 25
T162
T
Y
T
K
E
T
Q
T
P
V
M
A
Q
P
K
Site 26
T192
I
E
P
E
E
E
K
T
L
K
K
D
E
E
N
Site 27
S201
K
K
D
E
E
N
D
S
K
A
P
P
H
E
L
Site 28
S219
E
K
Q
Q
I
L
H
S
E
E
F
L
S
F
F
Site 29
S224
L
H
S
E
E
F
L
S
F
F
D
H
S
T
R
Site 30
S229
F
L
S
F
F
D
H
S
T
R
I
V
E
R
A
Site 31
Y247
Q
I
N
I
F
F
D
Y
S
G
R
D
L
E
D
Site 32
S248
I
N
I
F
F
D
Y
S
G
R
D
L
E
D
K
Site 33
S266
I
Q
A
G
A
K
L
S
L
N
R
Q
F
F
D
Site 34
S283
W
S
K
H
R
V
V
S
C
L
D
W
S
S
Q
Site 35
Y320
A
L
V
W
N
M
K
Y
K
K
T
T
P
E
Y
Site 36
T324
N
M
K
Y
K
K
T
T
P
E
Y
V
F
H
C
Site 37
Y327
Y
K
K
T
T
P
E
Y
V
F
H
C
Q
S
A
Site 38
T339
Q
S
A
V
M
S
A
T
F
A
K
F
H
P
N
Site 39
S364
I
V
L
W
D
N
R
S
N
K
R
T
P
V
Q
Site 40
T368
D
N
R
S
N
K
R
T
P
V
Q
R
T
P
L
Site 41
T373
K
R
T
P
V
Q
R
T
P
L
S
A
A
A
H
Site 42
S376
P
V
Q
R
T
P
L
S
A
A
A
H
T
H
P
Site 43
S409
S
T
D
G
K
I
C
S
W
S
L
D
M
L
S
Site 44
S411
D
G
K
I
C
S
W
S
L
D
M
L
S
H
P
Site 45
S416
S
W
S
L
D
M
L
S
H
P
Q
D
S
M
E
Site 46
S455
V
V
G
S
E
E
G
S
V
Y
T
A
C
R
H
Site 47
Y457
G
S
E
E
G
S
V
Y
T
A
C
R
H
G
S
Site 48
T458
S
E
E
G
S
V
Y
T
A
C
R
H
G
S
K
Site 49
S464
Y
T
A
C
R
H
G
S
K
A
G
I
S
E
M
Site 50
S469
H
G
S
K
A
G
I
S
E
M
F
E
G
H
Q
Site 51
T480
E
G
H
Q
G
P
I
T
G
I
H
C
H
A
A
Site 52
T505
V
T
S
S
F
D
W
T
V
K
L
W
T
T
K
Site 53
Y518
T
K
N
N
K
P
L
Y
S
F
E
D
N
A
D
Site 54
S519
K
N
N
K
P
L
Y
S
F
E
D
N
A
D
Y
Site 55
Y526
S
F
E
D
N
A
D
Y
V
Y
D
V
M
W
S
Site 56
Y528
E
D
N
A
D
Y
V
Y
D
V
M
W
S
P
T
Site 57
T558
L
W
N
L
N
N
D
T
E
V
P
T
A
S
I
Site 58
T579
A
L
N
R
V
R
W
T
H
S
G
R
E
I
A
Site 59
S581
N
R
V
R
W
T
H
S
G
R
E
I
A
V
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation