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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ORC2L
Full Name:
Origin recognition complex subunit 2
Alias:
ORC2; origin of replication 2-like; origin recognition complex 2; origin recognition complex protein 2; origin recognition complex, 2-like
Type:
DNA replication
Mass (Da):
65972
Number AA:
577
UniProt ID:
Q13416
International Prot ID:
IPI00013216
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000785
GO:0000808
GO:0000939
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003677
GO:0003688
PhosphoSite+
KinaseNET
Biological Process:
GO:0000122
GO:0006139
GO:0006259
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y55
K
I
I
K
K
P
E
Y
D
L
E
E
D
D
Q
Site 2
Y70
E
V
L
K
D
Q
N
Y
V
E
I
M
G
R
D
Site 3
S81
M
G
R
D
V
Q
E
S
L
K
N
G
S
A
T
Site 4
S86
Q
E
S
L
K
N
G
S
A
T
G
G
G
N
K
Site 5
Y95
T
G
G
G
N
K
V
Y
S
F
Q
N
R
K
H
Site 6
S96
G
G
G
N
K
V
Y
S
F
Q
N
R
K
H
S
Site 7
S103
S
F
Q
N
R
K
H
S
E
K
M
A
K
L
A
Site 8
T116
L
A
S
E
L
A
K
T
P
Q
K
S
V
S
F
Site 9
S120
L
A
K
T
P
Q
K
S
V
S
F
S
L
K
N
Site 10
S122
K
T
P
Q
K
S
V
S
F
S
L
K
N
D
P
Site 11
S124
P
Q
K
S
V
S
F
S
L
K
N
D
P
E
I
Site 12
S138
I
T
I
N
V
P
Q
S
S
K
G
H
S
A
S
Site 13
S139
T
I
N
V
P
Q
S
S
K
G
H
S
A
S
D
Site 14
S143
P
Q
S
S
K
G
H
S
A
S
D
K
V
Q
P
Site 15
S145
S
S
K
G
H
S
A
S
D
K
V
Q
P
K
N
Site 16
S156
Q
P
K
N
N
D
K
S
E
F
L
S
T
A
P
Site 17
S160
N
D
K
S
E
F
L
S
T
A
P
R
S
L
R
Site 18
T161
D
K
S
E
F
L
S
T
A
P
R
S
L
R
K
Site 19
S165
F
L
S
T
A
P
R
S
L
R
K
R
L
I
V
Site 20
S175
K
R
L
I
V
P
R
S
H
S
D
S
E
S
E
Site 21
S177
L
I
V
P
R
S
H
S
D
S
E
S
E
Y
S
Site 22
S179
V
P
R
S
H
S
D
S
E
S
E
Y
S
A
S
Site 23
S181
R
S
H
S
D
S
E
S
E
Y
S
A
S
N
S
Site 24
Y183
H
S
D
S
E
S
E
Y
S
A
S
N
S
E
D
Site 25
S184
S
D
S
E
S
E
Y
S
A
S
N
S
E
D
D
Site 26
S186
S
E
S
E
Y
S
A
S
N
S
E
D
D
E
G
Site 27
S188
S
E
Y
S
A
S
N
S
E
D
D
E
G
V
A
Site 28
T202
A
Q
E
H
E
E
D
T
N
A
V
I
F
S
Q
Site 29
S208
D
T
N
A
V
I
F
S
Q
K
I
Q
A
Q
N
Site 30
S219
Q
A
Q
N
R
V
V
S
A
P
V
G
K
E
T
Site 31
T226
S
A
P
V
G
K
E
T
P
S
K
R
M
K
R
Site 32
S228
P
V
G
K
E
T
P
S
K
R
M
K
R
D
K
Site 33
T236
K
R
M
K
R
D
K
T
S
D
L
V
E
E
Y
Site 34
S237
R
M
K
R
D
K
T
S
D
L
V
E
E
Y
F
Site 35
Y243
T
S
D
L
V
E
E
Y
F
E
A
H
S
S
S
Site 36
S248
E
E
Y
F
E
A
H
S
S
S
K
V
L
T
S
Site 37
S249
E
Y
F
E
A
H
S
S
S
K
V
L
T
S
D
Site 38
S250
Y
F
E
A
H
S
S
S
K
V
L
T
S
D
R
Site 39
T254
H
S
S
S
K
V
L
T
S
D
R
T
L
Q
K
Site 40
S255
S
S
S
K
V
L
T
S
D
R
T
L
Q
K
L
Site 41
T258
K
V
L
T
S
D
R
T
L
Q
K
L
K
R
A
Site 42
T271
R
A
K
L
D
Q
Q
T
L
R
N
L
L
S
K
Site 43
S277
Q
T
L
R
N
L
L
S
K
V
S
P
S
F
S
Site 44
S280
R
N
L
L
S
K
V
S
P
S
F
S
A
E
L
Site 45
S282
L
L
S
K
V
S
P
S
F
S
A
E
L
K
Q
Site 46
S284
S
K
V
S
P
S
F
S
A
E
L
K
Q
L
N
Site 47
Y294
L
K
Q
L
N
Q
Q
Y
E
K
L
F
H
K
W
Site 48
S318
I
V
L
Y
G
L
G
S
K
R
D
L
L
E
R
Site 49
T328
D
L
L
E
R
F
R
T
T
M
L
Q
D
S
I
Site 50
T329
L
L
E
R
F
R
T
T
M
L
Q
D
S
I
H
Site 51
T365
E
V
L
D
H
M
G
T
F
R
S
I
L
D
Q
Site 52
S385
N
K
F
K
E
D
S
S
L
E
L
F
L
L
I
Site 53
S397
L
L
I
H
N
L
D
S
Q
M
L
R
G
E
K
Site 54
S405
Q
M
L
R
G
E
K
S
Q
Q
I
I
G
Q
L
Site 55
Y446
S
L
F
N
W
L
W
Y
E
T
T
T
Y
S
P
Site 56
Y451
L
W
Y
E
T
T
T
Y
S
P
Y
T
E
E
T
Site 57
S452
W
Y
E
T
T
T
Y
S
P
Y
T
E
E
T
S
Site 58
T455
T
T
T
Y
S
P
Y
T
E
E
T
S
Y
E
N
Site 59
S459
S
P
Y
T
E
E
T
S
Y
E
N
S
L
L
V
Site 60
Y460
P
Y
T
E
E
T
S
Y
E
N
S
L
L
V
K
Site 61
S463
E
E
T
S
Y
E
N
S
L
L
V
K
Q
S
G
Site 62
S469
N
S
L
L
V
K
Q
S
G
S
L
P
L
S
S
Site 63
S475
Q
S
G
S
L
P
L
S
S
L
T
H
V
L
R
Site 64
S483
S
L
T
H
V
L
R
S
L
T
P
N
A
R
G
Site 65
T485
T
H
V
L
R
S
L
T
P
N
A
R
G
I
F
Site 66
Y498
I
F
R
L
L
I
K
Y
Q
L
D
N
Q
D
N
Site 67
S507
L
D
N
Q
D
N
P
S
Y
I
G
L
S
F
Q
Site 68
Y508
D
N
Q
D
N
P
S
Y
I
G
L
S
F
Q
D
Site 69
Y517
G
L
S
F
Q
D
F
Y
Q
Q
C
R
E
A
F
Site 70
S528
R
E
A
F
L
V
N
S
D
L
T
L
R
A
Q
Site 71
T531
F
L
V
N
S
D
L
T
L
R
A
Q
L
T
E
Site 72
T537
L
T
L
R
A
Q
L
T
E
F
R
D
H
K
L
Site 73
T551
L
I
R
T
K
K
G
T
D
G
V
E
Y
L
L
Site 74
Y556
K
G
T
D
G
V
E
Y
L
L
I
P
V
D
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation