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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MSLN
Full Name:
Mesothelin
Alias:
CAK1 antigen;Pre-pro-megakaryocyte-potentiating factor
Type:
Mass (Da):
68986
Number AA:
630
UniProt ID:
Q13421
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T36
G
W
V
Q
P
S
R
T
L
A
G
E
T
G
Q
Site 2
S60
A
N
P
P
N
I
S
S
L
S
P
R
Q
L
L
Site 3
S62
P
P
N
I
S
S
L
S
P
R
Q
L
L
G
F
Site 4
T79
A
E
V
S
G
L
S
T
E
R
V
R
E
L
A
Site 5
S109
R
C
L
A
H
R
L
S
E
P
P
E
D
L
D
Site 6
S142
Q
A
C
T
R
F
F
S
R
I
T
K
A
N
V
Site 7
S178
G
V
R
G
S
L
L
S
E
A
D
V
R
A
L
Site 8
S200
P
G
R
F
V
A
E
S
A
E
V
L
L
P
R
Site 9
Y234
L
Q
G
G
G
P
P
Y
G
P
P
S
T
W
S
Site 10
S238
G
P
P
Y
G
P
P
S
T
W
S
V
S
T
M
Site 11
T239
P
P
Y
G
P
P
S
T
W
S
V
S
T
M
D
Site 12
S241
Y
G
P
P
S
T
W
S
V
S
T
M
D
A
L
Site 13
S243
P
P
S
T
W
S
V
S
T
M
D
A
L
R
G
Site 14
S275
V
A
A
W
R
Q
R
S
S
R
D
P
S
W
R
Site 15
S276
A
A
W
R
Q
R
S
S
R
D
P
S
W
R
Q
Site 16
S280
Q
R
S
S
R
D
P
S
W
R
Q
P
E
R
T
Site 17
T287
S
W
R
Q
P
E
R
T
I
L
R
P
R
F
R
Site 18
T300
F
R
R
E
V
E
K
T
A
C
P
S
G
K
K
Site 19
S314
K
A
R
E
I
D
E
S
L
I
F
Y
K
K
W
Site 20
Y318
I
D
E
S
L
I
F
Y
K
K
W
E
L
E
A
Site 21
Y360
K
H
K
L
D
E
L
Y
P
Q
G
Y
P
E
S
Site 22
Y364
D
E
L
Y
P
Q
G
Y
P
E
S
V
I
Q
H
Site 23
S380
G
Y
L
F
L
K
M
S
P
E
D
I
R
K
W
Site 24
T390
D
I
R
K
W
N
V
T
S
L
E
T
L
K
A
Site 25
S408
V
N
K
G
H
E
M
S
P
Q
A
P
R
R
P
Site 26
T437
R
G
Q
L
D
K
D
T
L
D
T
L
T
A
F
Site 27
T440
L
D
K
D
T
L
D
T
L
T
A
F
Y
P
G
Site 28
T442
K
D
T
L
D
T
L
T
A
F
Y
P
G
Y
L
Site 29
S451
F
Y
P
G
Y
L
C
S
L
S
P
E
E
L
S
Site 30
S453
P
G
Y
L
C
S
L
S
P
E
E
L
S
S
V
Site 31
S458
S
L
S
P
E
E
L
S
S
V
P
P
S
S
I
Site 32
S459
L
S
P
E
E
L
S
S
V
P
P
S
S
I
W
Site 33
S463
E
L
S
S
V
P
P
S
S
I
W
A
V
R
P
Site 34
S464
L
S
S
V
P
P
S
S
I
W
A
V
R
P
Q
Site 35
T475
V
R
P
Q
D
L
D
T
C
D
P
R
Q
L
D
Site 36
Y485
P
R
Q
L
D
V
L
Y
P
K
A
R
L
A
F
Site 37
Y500
Q
N
M
N
G
S
E
Y
F
V
K
I
Q
S
F
Site 38
S520
T
E
D
L
K
A
L
S
Q
Q
N
V
S
M
D
Site 39
T530
N
V
S
M
D
L
A
T
F
M
K
L
R
T
D
Site 40
T581
Q
R
Q
D
D
L
D
T
L
G
L
G
L
Q
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation