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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPIG
Full Name:
Peptidyl-prolyl cis-trans isomerase G
Alias:
CASP10; Cyclophilin G; Peptidyl-prolyl isomerase G; PPIase G; Rotamase G; SR-cyp
Type:
Enzyme, isomerase, cyclophilin
Mass (Da):
88617
Number AA:
754
UniProt ID:
Q13427
International Prot ID:
IPI00006298
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016363
GO:0016607
Uniprot
OncoNet
Molecular Function:
GO:0016018
GO:0003755
PhosphoSite+
KinaseNET
Biological Process:
GO:0008380
GO:0006457
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S53
G
E
K
G
T
G
K
S
T
Q
K
P
L
H
Y
Site 2
T54
E
K
G
T
G
K
S
T
Q
K
P
L
H
Y
K
Site 3
Y60
S
T
Q
K
P
L
H
Y
K
S
C
L
F
H
R
Site 4
S80
M
V
Q
G
G
D
F
S
E
G
N
G
R
G
G
Site 5
S89
G
N
G
R
G
G
E
S
I
Y
G
G
F
F
E
Site 6
Y91
G
R
G
G
E
S
I
Y
G
G
F
F
E
D
E
Site 7
S99
G
G
F
F
E
D
E
S
F
A
V
K
H
N
K
Site 8
S111
H
N
K
E
F
L
L
S
M
A
N
R
G
K
D
Site 9
S122
R
G
K
D
T
N
G
S
Q
F
F
I
T
T
K
Site 10
T127
N
G
S
Q
F
F
I
T
T
K
P
T
P
H
L
Site 11
T131
F
F
I
T
T
K
P
T
P
H
L
D
G
H
H
Site 12
T159
R
E
I
E
N
Q
K
T
D
A
A
S
K
P
F
Site 13
S181
C
G
E
L
I
P
K
S
K
V
K
K
E
E
K
Site 14
S193
E
E
K
K
R
H
K
S
S
S
S
S
S
S
S
Site 15
S194
E
K
K
R
H
K
S
S
S
S
S
S
S
S
S
Site 16
S195
K
K
R
H
K
S
S
S
S
S
S
S
S
S
S
Site 17
S196
K
R
H
K
S
S
S
S
S
S
S
S
S
S
D
Site 18
S197
R
H
K
S
S
S
S
S
S
S
S
S
S
D
S
Site 19
S198
H
K
S
S
S
S
S
S
S
S
S
S
D
S
D
Site 20
S199
K
S
S
S
S
S
S
S
S
S
S
D
S
D
S
Site 21
S200
S
S
S
S
S
S
S
S
S
S
D
S
D
S
S
Site 22
S201
S
S
S
S
S
S
S
S
S
D
S
D
S
S
S
Site 23
S202
S
S
S
S
S
S
S
S
D
S
D
S
S
S
D
Site 24
S204
S
S
S
S
S
S
D
S
D
S
S
S
D
S
Q
Site 25
S206
S
S
S
S
D
S
D
S
S
S
D
S
Q
S
S
Site 26
S207
S
S
S
D
S
D
S
S
S
D
S
Q
S
S
S
Site 27
S208
S
S
D
S
D
S
S
S
D
S
Q
S
S
S
D
Site 28
S210
D
S
D
S
S
S
D
S
Q
S
S
S
D
S
S
Site 29
S212
D
S
S
S
D
S
Q
S
S
S
D
S
S
D
S
Site 30
S213
S
S
S
D
S
Q
S
S
S
D
S
S
D
S
E
Site 31
S214
S
S
D
S
Q
S
S
S
D
S
S
D
S
E
S
Site 32
S216
D
S
Q
S
S
S
D
S
S
D
S
E
S
A
T
Site 33
S217
S
Q
S
S
S
D
S
S
D
S
E
S
A
T
E
Site 34
S219
S
S
S
D
S
S
D
S
E
S
A
T
E
E
K
Site 35
S221
S
D
S
S
D
S
E
S
A
T
E
E
K
S
K
Site 36
T223
S
S
D
S
E
S
A
T
E
E
K
S
K
K
R
Site 37
S227
E
S
A
T
E
E
K
S
K
K
R
K
K
K
H
Site 38
S238
K
K
K
H
R
K
N
S
R
K
H
K
K
E
K
Site 39
S251
E
K
K
K
R
K
K
S
K
K
S
A
S
S
E
Site 40
S254
K
R
K
K
S
K
K
S
A
S
S
E
S
E
A
Site 41
S256
K
K
S
K
K
S
A
S
S
E
S
E
A
E
N
Site 42
S257
K
S
K
K
S
A
S
S
E
S
E
A
E
N
L
Site 43
S259
K
K
S
A
S
S
E
S
E
A
E
N
L
E
A
Site 44
S270
N
L
E
A
Q
P
Q
S
T
V
R
P
E
E
I
Site 45
T271
L
E
A
Q
P
Q
S
T
V
R
P
E
E
I
P
Site 46
S290
N
R
F
L
M
R
K
S
P
P
K
A
D
E
K
Site 47
S315
R
E
C
N
P
P
N
S
Q
P
A
S
Y
Q
R
Site 48
S319
P
P
N
S
Q
P
A
S
Y
Q
R
R
L
L
V
Site 49
Y320
P
N
S
Q
P
A
S
Y
Q
R
R
L
L
V
T
Site 50
T327
Y
Q
R
R
L
L
V
T
R
S
G
R
K
I
K
Site 51
S329
R
R
L
L
V
T
R
S
G
R
K
I
K
G
R
Site 52
Y341
K
G
R
G
P
R
R
Y
R
T
P
S
R
S
R
Site 53
T343
R
G
P
R
R
Y
R
T
P
S
R
S
R
S
R
Site 54
S345
P
R
R
Y
R
T
P
S
R
S
R
S
R
D
R
Site 55
S347
R
Y
R
T
P
S
R
S
R
S
R
D
R
F
R
Site 56
S349
R
T
P
S
R
S
R
S
R
D
R
F
R
R
S
Site 57
S356
S
R
D
R
F
R
R
S
E
T
P
P
H
W
R
Site 58
T358
D
R
F
R
R
S
E
T
P
P
H
W
R
Q
E
Site 59
S375
R
A
Q
R
M
R
V
S
S
G
E
R
W
I
K
Site 60
S376
A
Q
R
M
R
V
S
S
G
E
R
W
I
K
G
Site 61
S386
R
W
I
K
G
D
K
S
E
L
N
E
I
K
E
Site 62
S397
E
I
K
E
N
Q
R
S
P
V
R
V
K
E
R
Site 63
T407
R
V
K
E
R
K
I
T
D
H
R
N
V
S
E
Site 64
S413
I
T
D
H
R
N
V
S
E
S
P
N
R
K
N
Site 65
S415
D
H
R
N
V
S
E
S
P
N
R
K
N
E
K
Site 66
S431
K
K
V
K
D
H
K
S
N
S
K
E
R
D
I
Site 67
S433
V
K
D
H
K
S
N
S
K
E
R
D
I
R
R
Site 68
S442
E
R
D
I
R
R
N
S
E
K
D
D
K
Y
K
Site 69
Y448
N
S
E
K
D
D
K
Y
K
N
K
V
K
K
R
Site 70
S458
K
V
K
K
R
A
K
S
K
S
R
S
K
S
K
Site 71
S460
K
K
R
A
K
S
K
S
R
S
K
S
K
E
K
Site 72
S462
R
A
K
S
K
S
R
S
K
S
K
E
K
S
K
Site 73
S464
K
S
K
S
R
S
K
S
K
E
K
S
K
S
K
Site 74
S468
R
S
K
S
K
E
K
S
K
S
K
E
R
D
S
Site 75
S470
K
S
K
E
K
S
K
S
K
E
R
D
S
K
H
Site 76
S475
S
K
S
K
E
R
D
S
K
H
N
R
N
E
E
Site 77
S487
N
E
E
K
R
M
R
S
R
S
K
G
R
D
H
Site 78
S489
E
K
R
M
R
S
R
S
K
G
R
D
H
E
N
Site 79
S504
V
K
E
K
E
K
Q
S
D
S
K
G
K
D
Q
Site 80
S516
K
D
Q
E
R
S
R
S
K
E
K
S
K
Q
L
Site 81
S520
R
S
R
S
K
E
K
S
K
Q
L
E
S
K
S
Site 82
S525
E
K
S
K
Q
L
E
S
K
S
N
E
H
D
H
Site 83
S527
S
K
Q
L
E
S
K
S
N
E
H
D
H
S
K
Site 84
S533
K
S
N
E
H
D
H
S
K
S
K
E
K
D
R
Site 85
S535
N
E
H
D
H
S
K
S
K
E
K
D
R
R
A
Site 86
S544
E
K
D
R
R
A
Q
S
R
S
R
E
C
D
I
Site 87
S546
D
R
R
A
Q
S
R
S
R
E
C
D
I
T
K
Site 88
T552
R
S
R
E
C
D
I
T
K
G
K
H
S
Y
N
Site 89
Y558
I
T
K
G
K
H
S
Y
N
S
R
T
R
E
R
Site 90
S560
K
G
K
H
S
Y
N
S
R
T
R
E
R
S
R
Site 91
T562
K
H
S
Y
N
S
R
T
R
E
R
S
R
S
R
Site 92
S566
N
S
R
T
R
E
R
S
R
S
R
D
R
S
R
Site 93
S568
R
T
R
E
R
S
R
S
R
D
R
S
R
R
V
Site 94
S572
R
S
R
S
R
D
R
S
R
R
V
R
S
R
T
Site 95
S577
D
R
S
R
R
V
R
S
R
T
H
D
R
D
R
Site 96
T579
S
R
R
V
R
S
R
T
H
D
R
D
R
S
R
Site 97
S585
R
T
H
D
R
D
R
S
R
S
K
E
Y
H
R
Site 98
S587
H
D
R
D
R
S
R
S
K
E
Y
H
R
Y
R
Site 99
Y590
D
R
S
R
S
K
E
Y
H
R
Y
R
E
Q
E
Site 100
Y593
R
S
K
E
Y
H
R
Y
R
E
Q
E
Y
R
R
Site 101
Y598
H
R
Y
R
E
Q
E
Y
R
R
R
G
R
S
R
Site 102
S604
E
Y
R
R
R
G
R
S
R
S
R
E
R
R
T
Site 103
S606
R
R
R
G
R
S
R
S
R
E
R
R
T
P
P
Site 104
T611
S
R
S
R
E
R
R
T
P
P
G
R
S
R
S
Site 105
S616
R
R
T
P
P
G
R
S
R
S
K
D
R
R
R
Site 106
S618
T
P
P
G
R
S
R
S
K
D
R
R
R
R
R
Site 107
S628
R
R
R
R
R
R
D
S
R
S
S
E
R
E
E
Site 108
S630
R
R
R
R
D
S
R
S
S
E
R
E
E
S
Q
Site 109
S631
R
R
R
D
S
R
S
S
E
R
E
E
S
Q
S
Site 110
S636
R
S
S
E
R
E
E
S
Q
S
R
N
K
D
K
Site 111
S638
S
E
R
E
E
S
Q
S
R
N
K
D
K
Y
R
Site 112
Y644
Q
S
R
N
K
D
K
Y
R
N
Q
E
S
K
S
Site 113
S651
Y
R
N
Q
E
S
K
S
S
H
R
K
E
N
S
Site 114
S652
R
N
Q
E
S
K
S
S
H
R
K
E
N
S
E
Site 115
S658
S
S
H
R
K
E
N
S
E
S
E
K
R
M
Y
Site 116
S660
H
R
K
E
N
S
E
S
E
K
R
M
Y
S
K
Site 117
Y665
S
E
S
E
K
R
M
Y
S
K
S
R
D
H
N
Site 118
S666
E
S
E
K
R
M
Y
S
K
S
R
D
H
N
S
Site 119
S668
E
K
R
M
Y
S
K
S
R
D
H
N
S
S
N
Site 120
S673
S
K
S
R
D
H
N
S
S
N
N
S
R
E
K
Site 121
S674
K
S
R
D
H
N
S
S
N
N
S
R
E
K
K
Site 122
S677
D
H
N
S
S
N
N
S
R
E
K
K
A
D
R
Site 123
S687
K
K
A
D
R
D
Q
S
P
F
S
K
I
K
Q
Site 124
S690
D
R
D
Q
S
P
F
S
K
I
K
Q
S
S
Q
Site 125
S695
P
F
S
K
I
K
Q
S
S
Q
D
N
E
L
K
Site 126
S696
F
S
K
I
K
Q
S
S
Q
D
D
E
L
K
S
Site 127
S703
S
Q
D
N
E
L
K
S
S
M
L
K
N
K
E
Site 128
S704
Q
D
N
E
L
K
S
S
M
L
K
N
K
E
D
Site 129
S716
K
E
D
E
K
I
R
S
S
V
E
K
E
N
Q
Site 130
S717
E
D
E
K
I
R
S
S
V
E
K
E
N
Q
K
Site 131
S725
V
E
K
E
N
Q
K
S
K
G
Q
E
N
D
H
Site 132
S744
N
K
K
F
D
H
E
S
S
P
G
T
D
E
D
Site 133
S745
K
K
F
D
H
E
S
S
P
G
T
D
E
D
K
Site 134
T748
D
H
E
S
S
P
G
T
D
E
D
K
S
G
_
Site 135
S753
P
G
T
D
E
D
K
S
G
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation