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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FKBP5
Full Name:
Peptidyl-prolyl cis-trans isomerase FKBP5
Alias:
51 kDa FK506-binding protein; 54 kDa progesterone receptor-associated immunophilin; AIG6; Androgen-regulated protein 6; FF1 antigen; FK506 binding protein 5; FKB5; FKBP- 51; FKBP51; FKBP54; HSP90-binding immunophilin; P54; Peptidyl-prolyl cis-trans isomerase; PPIase; Ptg-10; Rotamase
Type:
Isomerase; Chaperone; EC 5.2.1.8
Mass (Da):
51212
Number AA:
457
UniProt ID:
Q13451
International Prot ID:
IPI00218775
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0005528
GO:0031072
GO:0003755
PhosphoSite+
KinaseNET
Biological Process:
GO:0006457
GO:0008152
GO:0009987
Phosida
TranscriptoNet
STRING
Kinexus Products
Peptidyl-prolyl cis-trans isomerase FKBP5 pan-specific antibody AB-NN249-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN249-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
G
A
K
N
N
E
E
S
P
T
A
T
V
A
E
Site 2
T15
K
N
N
E
E
S
P
T
A
T
V
A
E
Q
G
Site 3
T17
N
E
E
S
P
T
A
T
V
A
E
Q
G
E
D
Site 4
T26
A
E
Q
G
E
D
I
T
S
K
K
D
R
G
V
Site 5
S27
E
Q
G
E
D
I
T
S
K
K
D
R
G
V
L
Site 6
T46
R
V
G
N
G
E
E
T
P
M
I
G
D
K
V
Site 7
Y54
P
M
I
G
D
K
V
Y
V
H
Y
K
G
K
L
Site 8
S62
V
H
Y
K
G
K
L
S
N
G
K
K
F
D
S
Site 9
S69
S
N
G
K
K
F
D
S
S
H
D
R
N
E
P
Site 10
S70
N
G
K
K
F
D
S
S
H
D
R
N
E
P
F
Site 11
S80
R
N
E
P
F
V
F
S
L
G
K
G
Q
V
I
Site 12
Y111
H
L
L
C
K
P
E
Y
A
Y
G
S
A
G
S
Site 13
Y113
L
C
K
P
E
Y
A
Y
G
S
A
G
S
L
P
Site 14
S118
Y
A
Y
G
S
A
G
S
L
P
K
I
P
S
N
Site 15
T152
D
G
G
I
I
R
R
T
K
R
K
G
E
G
Y
Site 16
Y159
T
K
R
K
G
E
G
Y
S
N
P
N
E
G
A
Site 17
S160
K
R
K
G
E
G
Y
S
N
P
N
E
G
A
T
Site 18
T189
D
C
R
D
V
A
F
T
V
G
E
G
E
D
H
Site 19
Y218
R
E
E
Q
C
I
L
Y
L
G
P
R
Y
G
F
Site 20
Y223
I
L
Y
L
G
P
R
Y
G
F
G
E
A
G
K
Site 21
Y243
E
P
N
A
E
L
I
Y
E
V
T
L
K
S
F
Site 22
S249
I
Y
E
V
T
L
K
S
F
E
K
A
K
E
S
Site 23
T276
A
I
V
K
E
K
G
T
V
Y
F
K
G
G
K
Site 24
Y278
V
K
E
K
G
T
V
Y
F
K
G
G
K
Y
M
Site 25
Y284
V
Y
F
K
G
G
K
Y
M
Q
A
V
I
Q
Y
Site 26
S305
L
E
M
E
Y
G
L
S
E
K
E
S
K
A
S
Site 27
S309
Y
G
L
S
E
K
E
S
K
A
S
E
S
F
L
Site 28
S312
S
E
K
E
S
K
A
S
E
S
F
L
L
A
A
Site 29
Y327
F
L
N
L
A
M
C
Y
L
K
L
R
E
Y
T
Site 30
Y333
C
Y
L
K
L
R
E
Y
T
K
A
V
E
C
C
Site 31
T334
Y
L
K
L
R
E
Y
T
K
A
V
E
C
C
D
Site 32
S348
D
K
A
L
G
L
D
S
A
N
E
K
G
L
Y
Site 33
Y355
S
A
N
E
K
G
L
Y
R
R
G
E
A
Q
L
Site 34
Y409
N
E
R
D
R
R
I
Y
A
N
M
F
K
K
F
Site 35
T433
N
K
A
M
G
K
K
T
S
E
G
V
T
N
E
Site 36
S434
K
A
M
G
K
K
T
S
E
G
V
T
N
E
K
Site 37
T438
K
K
T
S
E
G
V
T
N
E
K
G
T
D
S
Site 38
S445
T
N
E
K
G
T
D
S
Q
A
M
E
E
E
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation