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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Tnk1
Full Name:
Non-receptor tyrosine-protein kinase TNK1
Alias:
CD38 negative kinase 1; EC 2.7.10.2
Type:
Protein-serine kinase, TK group, Ack family
Mass (Da):
72468
Number AA:
666
UniProt ID:
Q13470
International Prot ID:
IPI00022633
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004715
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0030308
GO:0046777
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Non-receptor tyrosine-protein kinase TNK1 pan-specific antibody AB-NK297-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK297-1#Non-receptor tyrosine-protein kinase TNK1 Y277 phosphosite-specific antibody AB-PK832#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK832#Non-receptor tyrosine-protein kinase TNK1 (R274-G280, human) pY277 phosphopeptide - Powder PE-04AQC80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQC80
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S60
R
P
A
Q
R
R
L
S
E
A
L
K
R
L
R
Site 2
S68
E
A
L
K
R
L
R
S
G
P
K
S
K
N
W
Site 3
S72
R
L
R
S
G
P
K
S
K
N
W
V
Y
K
I
Site 4
Y77
P
K
S
K
N
W
V
Y
K
I
L
G
G
F
A
Site 5
T91
A
P
E
H
K
E
P
T
L
P
S
D
S
P
R
Site 6
S94
H
K
E
P
T
L
P
S
D
S
P
R
H
L
P
Site 7
S96
E
P
T
L
P
S
D
S
P
R
H
L
P
E
P
Site 8
S142
W
T
L
P
S
G
K
S
V
P
V
A
V
K
S
Site 9
S170
G
D
F
L
R
E
V
S
V
M
M
N
L
E
H
Site 10
T209
G
S
L
H
A
R
L
T
A
P
A
P
T
P
P
Site 11
T214
R
L
T
A
P
A
P
T
P
P
L
L
V
A
L
Site 12
Y235
Q
L
A
G
A
M
A
Y
L
G
A
R
G
L
V
Site 13
S255
T
R
N
L
L
L
A
S
P
R
T
I
K
V
A
Site 14
Y277
L
G
G
A
R
G
R
Y
V
M
G
G
P
R
P
Non-receptor tyrosine-protein kinase TNK1 Y277 phosphosite-specific antibody AB-PK832#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK832#Non-receptor tyrosine-protein kinase TNK1 (R274-G280, human) pY277 phosphopeptide - Powder PE-04AQC80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQC80
Site 15
Y287
G
G
P
R
P
I
P
Y
A
W
C
A
P
E
S
Site 16
S301
S
L
R
H
G
A
F
S
S
A
S
D
V
W
M
Site 17
S318
V
T
L
W
E
M
F
S
G
G
E
E
P
W
A
Site 18
Y353
P
L
C
S
R
A
L
Y
S
L
A
L
R
C
W
Site 19
S369
P
H
P
A
D
R
P
S
F
S
H
L
E
G
L
Site 20
S371
P
A
D
R
P
S
F
S
H
L
E
G
L
L
Q
Site 21
S383
L
L
Q
E
A
G
P
S
E
A
C
C
V
R
D
Site 22
T406
M
E
T
G
D
P
I
T
V
I
E
G
S
S
S
Site 23
S411
P
I
T
V
I
E
G
S
S
S
F
H
S
P
D
Site 24
S412
I
T
V
I
E
G
S
S
S
F
H
S
P
D
S
Site 25
S413
T
V
I
E
G
S
S
S
F
H
S
P
D
S
T
Site 26
S416
E
G
S
S
S
F
H
S
P
D
S
T
I
W
K
Site 27
S419
S
S
F
H
S
P
D
S
T
I
W
K
G
Q
N
Site 28
T420
S
F
H
S
P
D
S
T
I
W
K
G
Q
N
G
Site 29
T429
W
K
G
Q
N
G
R
T
F
K
V
G
S
F
P
Site 30
T458
T
R
P
V
H
R
G
T
P
A
R
G
D
Q
H
Site 31
S468
R
G
D
Q
H
P
G
S
I
D
G
D
R
K
K
Site 32
S500
L
E
R
M
K
G
I
S
R
S
L
E
S
V
L
Site 33
S502
R
M
K
G
I
S
R
S
L
E
S
V
L
S
L
Site 34
S505
G
I
S
R
S
L
E
S
V
L
S
L
G
P
R
Site 35
S508
R
S
L
E
S
V
L
S
L
G
P
R
P
T
G
Site 36
T514
L
S
L
G
P
R
P
T
G
G
G
S
S
P
P
Site 37
S518
P
R
P
T
G
G
G
S
S
P
P
E
I
R
Q
Site 38
S519
R
P
T
G
G
G
S
S
P
P
E
I
R
Q
A
Site 39
S543
L
P
P
R
P
P
L
S
S
S
S
P
Q
P
S
Site 40
S544
P
P
R
P
P
L
S
S
S
S
P
Q
P
S
Q
Site 41
S545
P
R
P
P
L
S
S
S
S
P
Q
P
S
Q
P
Site 42
S546
R
P
P
L
S
S
S
S
P
Q
P
S
Q
P
S
Site 43
S550
S
S
S
S
P
Q
P
S
Q
P
S
R
E
R
L
Site 44
S553
S
P
Q
P
S
Q
P
S
R
E
R
L
P
W
P
Site 45
S582
A
R
K
A
A
A
L
S
G
G
L
L
S
D
P
Site 46
S587
A
L
S
G
G
L
L
S
D
P
E
L
Q
R
K
Site 47
S601
K
I
M
E
V
E
L
S
V
H
G
V
T
H
Q
Site 48
S637
V
D
Q
L
F
H
L
S
S
R
S
R
A
D
C
Site 49
S638
D
Q
L
F
H
L
S
S
R
S
R
A
D
C
W
Site 50
S640
L
F
H
L
S
S
R
S
R
A
D
C
W
R
I
Site 51
Y651
C
W
R
I
L
E
H
Y
Q
W
D
L
S
A
A
Site 52
S659
Q
W
D
L
S
A
A
S
R
Y
V
L
A
R
P
Site 53
Y661
D
L
S
A
A
S
R
Y
V
L
A
R
P
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation