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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TOP3A
Full Name:
DNA topoisomerase 3-alpha
Alias:
DNA topoisomerase III alpha; TOP3; TOP3alpha; topoisomerase (DNA) III alpha; topoisomerase III alpha
Type:
Isomerase; EC 5.99.1.2
Mass (Da):
112370
Number AA:
UniProt ID:
Q13472
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016605
GO:0005694
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003917
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006265
GO:0006268
GO:0007126
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
R
P
E
D
R
A
F
S
R
A
A
M
E
M
A
Site 2
S54
K
G
I
A
D
L
L
S
N
G
R
M
R
R
R
Site 3
S65
M
R
R
R
E
G
L
S
K
F
N
K
I
Y
E
Site 4
Y71
L
S
K
F
N
K
I
Y
E
F
D
Y
H
L
Y
Site 5
Y75
N
K
I
Y
E
F
D
Y
H
L
Y
G
Q
N
V
Site 6
Y78
Y
E
F
D
Y
H
L
Y
G
Q
N
V
T
M
V
Site 7
Y121
F
E
A
E
I
E
K
Y
C
P
E
N
F
V
D
Site 8
T132
N
F
V
D
I
K
K
T
L
E
R
E
T
R
Q
Site 9
T137
K
K
T
L
E
R
E
T
R
Q
C
Q
A
L
V
Site 10
S179
Q
V
L
R
A
R
F
S
E
I
T
P
H
A
V
Site 11
T182
R
A
R
F
S
E
I
T
P
H
A
V
R
T
A
Site 12
S201
T
E
P
D
Q
R
V
S
D
A
V
D
V
R
Q
Site 13
S243
E
Q
L
I
S
Y
G
S
C
Q
F
P
T
L
G
Site 14
T294
R
H
R
L
F
N
H
T
A
C
L
V
L
Y
Q
Site 15
S316
A
T
V
V
E
V
R
S
K
P
K
S
K
W
R
Site 16
S320
E
V
R
S
K
P
K
S
K
W
R
P
Q
A
L
Site 17
T329
W
R
P
Q
A
L
D
T
V
E
L
E
K
L
A
Site 18
S337
V
E
L
E
K
L
A
S
R
K
L
R
I
N
A
Site 19
Y355
M
R
I
A
E
K
L
Y
T
Q
G
Y
I
S
Y
Site 20
T356
R
I
A
E
K
L
Y
T
Q
G
Y
I
S
Y
P
Site 21
Y359
E
K
L
Y
T
Q
G
Y
I
S
Y
P
R
T
E
Site 22
Y362
Y
T
Q
G
Y
I
S
Y
P
R
T
E
T
N
I
Site 23
T365
G
Y
I
S
Y
P
R
T
E
T
N
I
F
P
R
Site 24
T367
I
S
Y
P
R
T
E
T
N
I
F
P
R
D
L
Site 25
T377
F
P
R
D
L
N
L
T
V
L
V
E
Q
Q
T
Site 26
T384
T
V
L
V
E
Q
Q
T
P
D
P
R
W
G
A
Site 27
S395
R
W
G
A
F
A
Q
S
I
L
E
R
G
G
P
Site 28
T403
I
L
E
R
G
G
P
T
P
R
N
G
N
K
S
Site 29
S410
T
P
R
N
G
N
K
S
D
Q
A
H
P
P
I
Site 30
Y422
P
P
I
H
P
T
K
Y
T
N
N
L
Q
G
D
Site 31
Y434
Q
G
D
E
Q
R
L
Y
E
F
I
V
R
H
F
Site 32
Y481
A
R
N
Y
L
D
V
Y
P
Y
D
H
W
S
D
Site 33
Y483
N
Y
L
D
V
Y
P
Y
D
H
W
S
D
K
I
Site 34
Y494
S
D
K
I
L
P
V
Y
E
Q
G
S
H
F
Q
Site 35
S503
Q
G
S
H
F
Q
P
S
T
V
E
M
V
D
G
Site 36
T504
G
S
H
F
Q
P
S
T
V
E
M
V
D
G
E
Site 37
T512
V
E
M
V
D
G
E
T
S
P
P
K
L
L
T
Site 38
S513
E
M
V
D
G
E
T
S
P
P
K
L
L
T
E
Site 39
T537
H
G
I
G
T
D
A
T
H
A
E
H
I
E
T
Site 40
T544
T
H
A
E
H
I
E
T
I
K
A
R
M
Y
V
Site 41
Y550
E
T
I
K
A
R
M
Y
V
G
L
T
P
D
K
Site 42
T554
A
R
M
Y
V
G
L
T
P
D
K
R
F
L
P
Site 43
Y572
G
M
G
L
V
E
G
Y
D
S
M
G
Y
E
M
Site 44
S574
G
L
V
E
G
Y
D
S
M
G
Y
E
M
S
K
Site 45
Y577
E
G
Y
D
S
M
G
Y
E
M
S
K
P
D
L
Site 46
S580
D
S
M
G
Y
E
M
S
K
P
D
L
R
A
E
Site 47
Y613
L
R
Q
Q
V
Q
K
Y
K
Q
V
F
I
E
A
Site 48
Y634
L
D
E
A
L
A
Q
Y
F
G
N
G
T
E
L
Site 49
Y648
L
A
Q
Q
E
D
I
Y
P
A
M
P
E
P
I
Site 50
T669
N
K
D
M
V
L
K
T
K
K
N
G
G
F
Y
Site 51
Y676
T
K
K
N
G
G
F
Y
L
S
C
M
G
F
P
Site 52
S694
S
A
V
W
L
P
D
S
V
L
E
A
S
R
D
Site 53
S699
P
D
S
V
L
E
A
S
R
D
S
S
V
C
P
Site 54
S703
L
E
A
S
R
D
S
S
V
C
P
V
C
Q
P
Site 55
Y714
V
C
Q
P
H
P
V
Y
R
L
K
L
K
F
K
Site 56
S724
K
L
K
F
K
R
G
S
L
P
P
T
M
P
L
Site 57
T728
K
R
G
S
L
P
P
T
M
P
L
E
F
V
C
Site 58
S753
E
I
L
D
L
R
F
S
G
G
P
P
R
A
S
Site 59
S760
S
G
G
P
P
R
A
S
Q
P
S
G
R
L
Q
Site 60
S763
P
P
R
A
S
Q
P
S
G
R
L
Q
A
N
Q
Site 61
S771
G
R
L
Q
A
N
Q
S
L
N
R
M
D
N
S
Site 62
S778
S
L
N
R
M
D
N
S
Q
H
P
Q
P
A
D
Site 63
S786
Q
H
P
Q
P
A
D
S
R
Q
T
G
S
S
K
Site 64
T789
Q
P
A
D
S
R
Q
T
G
S
S
K
A
L
A
Site 65
S792
D
S
R
Q
T
G
S
S
K
A
L
A
Q
T
L
Site 66
T798
S
S
K
A
L
A
Q
T
L
P
P
P
T
A
A
Site 67
T803
A
Q
T
L
P
P
P
T
A
A
G
E
S
N
S
Site 68
S810
T
A
A
G
E
S
N
S
V
T
C
N
C
G
Q
Site 69
T812
A
G
E
S
N
S
V
T
C
N
C
G
Q
E
A
Site 70
T823
G
Q
E
A
V
L
L
T
V
R
K
E
G
P
N
Site 71
S851
N
F
F
L
W
A
D
S
P
N
P
G
A
G
G
Site 72
S870
A
Y
R
P
L
G
A
S
L
G
C
P
P
G
P
Site 73
S891
F
G
N
P
G
D
G
S
G
S
G
T
S
C
L
Site 74
S893
N
P
G
D
G
S
G
S
G
T
S
C
L
C
S
Site 75
T895
G
D
G
S
G
S
G
T
S
C
L
C
S
Q
P
Site 76
S896
D
G
S
G
S
G
T
S
C
L
C
S
Q
P
S
Site 77
S900
S
G
T
S
C
L
C
S
Q
P
S
V
T
R
T
Site 78
S903
S
C
L
C
S
Q
P
S
V
T
R
T
V
Q
K
Site 79
T907
S
Q
P
S
V
T
R
T
V
Q
K
D
G
P
N
Site 80
T940
F
Q
W
V
D
E
N
T
A
P
G
T
S
G
A
Site 81
S945
E
N
T
A
P
G
T
S
G
A
P
S
W
T
G
Site 82
S949
P
G
T
S
G
A
P
S
W
T
G
D
R
G
R
Site 83
T957
W
T
G
D
R
G
R
T
L
E
S
E
A
R
S
Site 84
S960
D
R
G
R
T
L
E
S
E
A
R
S
K
R
P
Site 85
S964
T
L
E
S
E
A
R
S
K
R
P
R
A
S
S
Site 86
S970
R
S
K
R
P
R
A
S
S
S
D
M
G
S
T
Site 87
S971
S
K
R
P
R
A
S
S
S
D
M
G
S
T
A
Site 88
S972
K
R
P
R
A
S
S
S
D
M
G
S
T
A
K
Site 89
S976
A
S
S
S
D
M
G
S
T
A
K
K
P
R
K
Site 90
S985
A
K
K
P
R
K
C
S
L
C
H
Q
P
G
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation