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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Gab1
Full Name:
GRB2-associated-binding protein 1
Alias:
GRB2-associated binder 1; GRB2-associated binding protein 1; Growth factor receptor bound protein 2-associated protein 1
Type:
Adapter/scaffold protein
Mass (Da):
76616
Number AA:
694
UniProt ID:
Q13480
International Prot ID:
IPI00031068
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005070
PhosphoSite+
KinaseNET
Biological Process:
GO:0008283
GO:0007173
GO:0008286
Phosida
TranscriptoNet
STRING
Kinexus Products
GRB2-associated-binding protein 1 (Q403-P409, human) pY406 phosphopeptide - Powder PE-04ACW80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ACW80
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
S
G
G
E
V
V
C
S
G
W
L
R
K
S
P
Site 2
S15
C
S
G
W
L
R
K
S
P
P
E
K
K
L
K
Site 3
Y24
P
E
K
K
L
K
R
Y
A
W
K
R
R
W
F
Site 4
S35
R
R
W
F
V
L
R
S
G
R
L
T
G
D
P
Site 5
T39
V
L
R
S
G
R
L
T
G
D
P
D
V
L
E
Site 6
Y47
G
D
P
D
V
L
E
Y
Y
K
N
D
H
A
K
Site 7
Y48
D
P
D
V
L
E
Y
Y
K
N
D
H
A
K
K
Site 8
T73
Q
Q
V
D
A
G
L
T
F
N
K
K
E
F
E
Site 9
S82
N
K
K
E
F
E
N
S
Y
I
F
D
I
N
T
Site 10
Y83
K
K
E
F
E
N
S
Y
I
F
D
I
N
T
I
Site 11
Y95
N
T
I
D
R
I
F
Y
L
V
A
D
S
E
E
Site 12
S130
D
P
V
K
P
P
G
S
S
L
Q
A
P
A
D
Site 13
T144
D
L
P
L
A
I
N
T
A
P
P
S
T
Q
A
Site 14
S148
A
I
N
T
A
P
P
S
T
Q
A
D
S
S
S
Site 15
T149
I
N
T
A
P
P
S
T
Q
A
D
S
S
S
A
Site 16
S153
P
P
S
T
Q
A
D
S
S
S
A
T
L
P
P
Site 17
S154
P
S
T
Q
A
D
S
S
S
A
T
L
P
P
P
Site 18
S155
S
T
Q
A
D
S
S
S
A
T
L
P
P
P
Y
Site 19
T157
Q
A
D
S
S
S
A
T
L
P
P
P
Y
Q
L
Site 20
Y162
S
A
T
L
P
P
P
Y
Q
L
I
N
V
P
P
Site 21
Y183
I
Q
E
D
P
Q
D
Y
L
L
L
I
N
C
Q
Site 22
S191
L
L
L
I
N
C
Q
S
K
K
P
E
P
T
R
Site 23
T199
K
K
P
E
P
T
R
T
H
A
D
S
A
K
S
Site 24
S203
P
T
R
T
H
A
D
S
A
K
S
T
S
S
E
Site 25
S206
T
H
A
D
S
A
K
S
T
S
S
E
T
D
C
Site 26
T207
H
A
D
S
A
K
S
T
S
S
E
T
D
C
N
Site 27
S209
D
S
A
K
S
T
S
S
E
T
D
C
N
D
N
Site 28
S219
D
C
N
D
N
V
P
S
H
K
N
P
A
S
S
Site 29
S225
P
S
H
K
N
P
A
S
S
Q
S
K
H
G
M
Site 30
S226
S
H
K
N
P
A
S
S
Q
S
K
H
G
M
N
Site 31
Y242
F
F
Q
Q
Q
M
I
Y
D
S
P
P
S
R
A
Site 32
S244
Q
Q
Q
M
I
Y
D
S
P
P
S
R
A
P
S
Site 33
S247
M
I
Y
D
S
P
P
S
R
A
P
S
A
S
V
Site 34
S251
S
P
P
S
R
A
P
S
A
S
V
D
S
S
L
Site 35
S253
P
S
R
A
P
S
A
S
V
D
S
S
L
Y
N
Site 36
S256
A
P
S
A
S
V
D
S
S
L
Y
N
L
P
R
Site 37
S257
P
S
A
S
V
D
S
S
L
Y
N
L
P
R
S
Site 38
Y259
A
S
V
D
S
S
L
Y
N
L
P
R
S
Y
S
Site 39
S264
S
L
Y
N
L
P
R
S
Y
S
H
D
V
L
P
Site 40
Y265
L
Y
N
L
P
R
S
Y
S
H
D
V
L
P
K
Site 41
S266
Y
N
L
P
R
S
Y
S
H
D
V
L
P
K
V
Site 42
S274
H
D
V
L
P
K
V
S
P
S
S
T
E
A
D
Site 43
S277
L
P
K
V
S
P
S
S
T
E
A
D
G
E
L
Site 44
T278
P
K
V
S
P
S
S
T
E
A
D
G
E
L
Y
Site 45
Y285
T
E
A
D
G
E
L
Y
V
F
N
T
P
S
G
Site 46
T289
G
E
L
Y
V
F
N
T
P
S
G
T
S
S
V
Site 47
S291
L
Y
V
F
N
T
P
S
G
T
S
S
V
E
T
Site 48
S295
N
T
P
S
G
T
S
S
V
E
T
Q
M
R
H
Site 49
T298
S
G
T
S
S
V
E
T
Q
M
R
H
V
S
I
Site 50
S304
E
T
Q
M
R
H
V
S
I
S
Y
D
I
P
P
Site 51
S306
Q
M
R
H
V
S
I
S
Y
D
I
P
P
T
P
Site 52
Y307
M
R
H
V
S
I
S
Y
D
I
P
P
T
P
G
Site 53
T312
I
S
Y
D
I
P
P
T
P
G
N
T
Y
Q
I
Site 54
T316
I
P
P
T
P
G
N
T
Y
Q
I
P
R
T
F
Site 55
Y317
P
P
T
P
G
N
T
Y
Q
I
P
R
T
F
P
Site 56
T322
N
T
Y
Q
I
P
R
T
F
P
E
G
T
L
G
Site 57
T327
P
R
T
F
P
E
G
T
L
G
Q
T
S
K
L
Site 58
T336
G
Q
T
S
K
L
D
T
I
P
D
I
P
P
P
Site 59
S355
P
H
P
A
H
D
R
S
P
V
E
T
C
S
I
Site 60
T359
H
D
R
S
P
V
E
T
C
S
I
P
R
T
A
Site 61
S361
R
S
P
V
E
T
C
S
I
P
R
T
A
S
D
Site 62
T365
E
T
C
S
I
P
R
T
A
S
D
T
D
S
S
Site 63
S367
C
S
I
P
R
T
A
S
D
T
D
S
S
Y
C
Site 64
T369
I
P
R
T
A
S
D
T
D
S
S
Y
C
I
P
Site 65
S371
R
T
A
S
D
T
D
S
S
Y
C
I
P
T
A
Site 66
S372
T
A
S
D
T
D
S
S
Y
C
I
P
T
A
G
Site 67
Y373
A
S
D
T
D
S
S
Y
C
I
P
T
A
G
M
Site 68
T377
D
S
S
Y
C
I
P
T
A
G
M
S
P
S
R
Site 69
S381
C
I
P
T
A
G
M
S
P
S
R
S
N
T
I
Site 70
S383
P
T
A
G
M
S
P
S
R
S
N
T
I
S
T
Site 71
S385
A
G
M
S
P
S
R
S
N
T
I
S
T
V
D
Site 72
T387
M
S
P
S
R
S
N
T
I
S
T
V
D
L
N
Site 73
S389
P
S
R
S
N
T
I
S
T
V
D
L
N
K
L
Site 74
S401
N
K
L
R
K
D
A
S
S
Q
D
C
Y
D
I
Site 75
S402
K
L
R
K
D
A
S
S
Q
D
C
Y
D
I
P
Site 76
Y406
D
A
S
S
Q
D
C
Y
D
I
P
R
A
F
P
GRB2-associated-binding protein 1 (Q403-P409, human) pY406 phosphopeptide - Powder PE-04ACW80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ACW80
Site 77
S414
D
I
P
R
A
F
P
S
D
R
S
S
S
L
E
Site 78
S417
R
A
F
P
S
D
R
S
S
S
L
E
G
F
H
Site 79
S418
A
F
P
S
D
R
S
S
S
L
E
G
F
H
N
Site 80
S419
F
P
S
D
R
S
S
S
L
E
G
F
H
N
H
Site 81
S437
K
N
V
L
T
V
G
S
V
S
S
E
E
L
D
Site 82
S439
V
L
T
V
G
S
V
S
S
E
E
L
D
E
N
Site 83
Y447
S
E
E
L
D
E
N
Y
V
P
M
N
P
N
S
Site 84
S454
Y
V
P
M
N
P
N
S
P
P
R
Q
H
S
S
Site 85
S460
N
S
P
P
R
Q
H
S
S
S
F
T
E
P
I
Site 86
S462
P
P
R
Q
H
S
S
S
F
T
E
P
I
Q
E
Site 87
T464
R
Q
H
S
S
S
F
T
E
P
I
Q
E
A
N
Site 88
Y472
E
P
I
Q
E
A
N
Y
V
P
M
T
P
G
T
Site 89
T476
E
A
N
Y
V
P
M
T
P
G
T
F
D
F
S
Site 90
S484
P
G
T
F
D
F
S
S
F
G
M
Q
V
P
P
Site 91
S499
P
A
H
M
G
F
R
S
S
P
K
T
P
P
R
Site 92
S500
A
H
M
G
F
R
S
S
P
K
T
P
P
R
R
Site 93
T503
G
F
R
S
S
P
K
T
P
P
R
R
P
V
P
Site 94
S551
E
L
Q
A
P
V
R
S
P
I
T
R
S
F
A
Site 95
S556
V
R
S
P
I
T
R
S
F
A
R
D
S
S
R
Site 96
S561
T
R
S
F
A
R
D
S
S
R
F
P
M
S
P
Site 97
S562
R
S
F
A
R
D
S
S
R
F
P
M
S
P
R
Site 98
S567
D
S
S
R
F
P
M
S
P
R
P
D
S
V
H
Site 99
S572
P
M
S
P
R
P
D
S
V
H
S
T
T
S
S
Site 100
S575
P
R
P
D
S
V
H
S
T
T
S
S
S
D
S
Site 101
T576
R
P
D
S
V
H
S
T
T
S
S
S
D
S
H
Site 102
T577
P
D
S
V
H
S
T
T
S
S
S
D
S
H
D
Site 103
S578
D
S
V
H
S
T
T
S
S
S
D
S
H
D
S
Site 104
S579
S
V
H
S
T
T
S
S
S
D
S
H
D
S
E
Site 105
S580
V
H
S
T
T
S
S
S
D
S
H
D
S
E
E
Site 106
S582
S
T
T
S
S
S
D
S
H
D
S
E
E
N
Y
Site 107
S585
S
S
S
D
S
H
D
S
E
E
N
Y
V
P
M
Site 108
Y589
S
H
D
S
E
E
N
Y
V
P
M
N
P
N
L
Site 109
S597
V
P
M
N
P
N
L
S
S
E
D
P
N
L
F
Site 110
S598
P
M
N
P
N
L
S
S
E
D
P
N
L
F
G
Site 111
S606
E
D
P
N
L
F
G
S
N
S
L
D
G
G
S
Site 112
S608
P
N
L
F
G
S
N
S
L
D
G
G
S
S
P
Site 113
S613
S
N
S
L
D
G
G
S
S
P
M
I
K
P
K
Site 114
S614
N
S
L
D
G
G
S
S
P
M
I
K
P
K
G
Site 115
Y627
K
G
D
K
Q
V
E
Y
L
D
L
D
L
D
S
Site 116
S634
Y
L
D
L
D
L
D
S
G
K
S
T
P
P
R
Site 117
S637
L
D
L
D
S
G
K
S
T
P
P
R
K
Q
K
Site 118
T638
D
L
D
S
G
K
S
T
P
P
R
K
Q
K
S
Site 119
S645
T
P
P
R
K
Q
K
S
S
G
S
G
S
S
V
Site 120
S646
P
P
R
K
Q
K
S
S
G
S
G
S
S
V
A
Site 121
S648
R
K
Q
K
S
S
G
S
G
S
S
V
A
D
E
Site 122
S650
Q
K
S
S
G
S
G
S
S
V
A
D
E
R
V
Site 123
S651
K
S
S
G
S
G
S
S
V
A
D
E
R
V
D
Site 124
Y659
V
A
D
E
R
V
D
Y
V
V
V
D
Q
Q
K
Site 125
T667
V
V
V
D
Q
Q
K
T
L
A
L
K
S
T
R
Site 126
S672
Q
K
T
L
A
L
K
S
T
R
E
A
W
T
D
Site 127
S683
A
W
T
D
G
R
Q
S
T
E
S
E
T
P
A
Site 128
T684
W
T
D
G
R
Q
S
T
E
S
E
T
P
A
K
Site 129
S686
D
G
R
Q
S
T
E
S
E
T
P
A
K
S
V
Site 130
T688
R
Q
S
T
E
S
E
T
P
A
K
S
V
K
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation