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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Smad4
Full Name:
Mothers against decapentaplegic homolog 4
Alias:
Deletion target in pancreatic carcinoma 4; Deletion target in pancreatic carcinoma 4 homolog; Deletion target in pancreatic carcinoma 4 homologue; DPC4; Dpc4; MADH4; Madh4; Mothers against decapentaplegic 4; Mothers against decapentaplegic homolog 4; Mothers against DPP 4; SMA4; Sma4; SMAD family member 4
Type:
Transcription protein, coactivator/corepressor
Mass (Da):
60439
Number AA:
552
UniProt ID:
Q13485
International Prot ID:
IPI00013404
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0032444
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0070412
GO:0010843
GO:0042803
PhosphoSite+
KinaseNET
Biological Process:
GO:0030509
GO:0007183
GO:0060395
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
D
N
M
S
I
T
N
T
P
T
S
N
D
A
C
Site 2
S12
S
I
T
N
T
P
T
S
N
D
A
C
L
S
I
Site 3
S32
C
H
R
Q
G
G
E
S
E
T
F
A
K
R
A
Site 4
T34
R
Q
G
G
E
S
E
T
F
A
K
R
A
I
E
Site 5
S56
E
K
K
D
E
L
D
S
L
I
T
A
I
T
T
Site 6
S69
T
T
N
G
A
H
P
S
K
C
V
T
I
Q
R
Site 7
T73
A
H
P
S
K
C
V
T
I
Q
R
T
L
D
G
Site 8
T77
K
C
V
T
I
Q
R
T
L
D
G
R
L
Q
V
Site 9
Y95
K
G
F
P
H
V
I
Y
A
R
L
W
R
W
P
Site 10
Y114
N
E
L
K
H
V
K
Y
C
Q
Y
A
F
D
L
Site 11
Y133
V
C
V
N
P
Y
H
Y
E
R
V
V
S
P
G
Site 12
S138
Y
H
Y
E
R
V
V
S
P
G
I
D
L
S
G
Site 13
S154
T
L
Q
S
N
A
P
S
S
M
M
V
K
D
E
Site 14
S155
L
Q
S
N
A
P
S
S
M
M
V
K
D
E
Y
Site 15
Y162
S
M
M
V
K
D
E
Y
V
H
D
F
E
G
Q
Site 16
S171
H
D
F
E
G
Q
P
S
L
S
T
E
G
H
S
Site 17
S173
F
E
G
Q
P
S
L
S
T
E
G
H
S
I
Q
Site 18
T174
E
G
Q
P
S
L
S
T
E
G
H
S
I
Q
T
Site 19
S187
Q
T
I
Q
H
P
P
S
N
R
A
S
T
E
T
Site 20
S191
H
P
P
S
N
R
A
S
T
E
T
Y
S
T
P
Site 21
T192
P
P
S
N
R
A
S
T
E
T
Y
S
T
P
A
Site 22
T194
S
N
R
A
S
T
E
T
Y
S
T
P
A
L
L
Site 23
Y195
N
R
A
S
T
E
T
Y
S
T
P
A
L
L
A
Site 24
S196
R
A
S
T
E
T
Y
S
T
P
A
L
L
A
P
Site 25
T197
A
S
T
E
T
Y
S
T
P
A
L
L
A
P
S
Site 26
S204
T
P
A
L
L
A
P
S
E
S
N
A
T
S
T
Site 27
S206
A
L
L
A
P
S
E
S
N
A
T
S
T
A
N
Site 28
S210
P
S
E
S
N
A
T
S
T
A
N
F
P
N
I
Site 29
S227
A
S
T
S
Q
P
A
S
I
L
G
G
S
H
S
Site 30
S232
P
A
S
I
L
G
G
S
H
S
E
G
L
L
Q
Site 31
S242
E
G
L
L
Q
I
A
S
G
P
Q
P
G
Q
Q
Site 32
T259
G
F
T
G
Q
P
A
T
Y
H
H
N
S
T
T
Site 33
Y260
F
T
G
Q
P
A
T
Y
H
H
N
S
T
T
T
Site 34
S271
S
T
T
T
W
T
G
S
R
T
A
P
Y
T
P
Site 35
Y276
T
G
S
R
T
A
P
Y
T
P
N
L
P
H
H
Site 36
T277
G
S
R
T
A
P
Y
T
P
N
L
P
H
H
Q
Site 37
S315
L
A
F
Q
P
P
I
S
N
H
P
A
P
E
Y
Site 38
T338
M
D
V
Q
V
G
E
T
F
K
V
P
S
S
C
Site 39
S343
G
E
T
F
K
V
P
S
S
C
P
I
V
T
V
Site 40
Y353
P
I
V
T
V
D
G
Y
V
D
P
S
G
G
D
Site 41
S368
R
F
C
L
G
Q
L
S
N
V
H
R
T
E
A
Site 42
Y413
A
V
F
V
Q
S
Y
Y
L
D
R
E
A
G
R
Site 43
Y430
G
D
A
V
H
K
I
Y
P
S
A
Y
I
K
V
Site 44
Y434
H
K
I
Y
P
S
A
Y
I
K
V
F
D
L
R
Site 45
S504
R
L
C
I
L
R
M
S
F
V
K
G
W
G
P
Site 46
Y513
V
K
G
W
G
P
D
Y
P
R
Q
S
I
K
E
Site 47
T521
P
R
Q
S
I
K
E
T
P
C
W
I
E
I
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation