KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PICALM
Full Name:
Phosphatidylinositol-binding clathrin assembly protein
Alias:
Clathrin assembly lymphoid myeloid leukemia protein; PICA; PICAL
Type:
Vesicle protein
Mass (Da):
70755
Number AA:
652
UniProt ID:
Q13492
International Prot ID:
IPI00290738
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0030118
GO:0030136
Uniprot
OncoNet
Molecular Function:
GO:0030276
GO:0005545
PhosphoSite+
KinaseNET
Biological Process:
GO:0048268
GO:0006898
GO:0030100
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
S
G
Q
S
L
T
D
R
I
T
A
A
Q
Site 2
T11
Q
S
L
T
D
R
I
T
A
A
Q
H
S
V
T
Site 3
S16
R
I
T
A
A
Q
H
S
V
T
G
S
A
V
S
Site 4
T18
T
A
A
Q
H
S
V
T
G
S
A
V
S
K
T
Site 5
S20
A
Q
H
S
V
T
G
S
A
V
S
K
T
V
C
Site 6
S23
S
V
T
G
S
A
V
S
K
T
V
C
K
A
T
Site 7
T25
T
G
S
A
V
S
K
T
V
C
K
A
T
T
H
Site 8
Y44
P
K
K
K
H
L
D
Y
L
I
Q
C
T
N
E
Site 9
S62
N
I
P
Q
L
A
D
S
L
F
E
R
T
T
N
Site 10
T67
A
D
S
L
F
E
R
T
T
N
S
S
W
V
V
Site 11
T68
D
S
L
F
E
R
T
T
N
S
S
W
V
V
V
Site 12
S71
F
E
R
T
T
N
S
S
W
V
V
V
F
K
S
Site 13
Y88
T
T
H
H
L
M
V
Y
G
N
E
R
F
I
Q
Site 14
Y96
G
N
E
R
F
I
Q
Y
L
A
S
R
N
T
L
Site 15
S99
R
F
I
Q
Y
L
A
S
R
N
T
L
F
N
L
Site 16
T102
Q
Y
L
A
S
R
N
T
L
F
N
L
S
N
F
Site 17
S107
R
N
T
L
F
N
L
S
N
F
L
D
K
S
G
Site 18
S113
L
S
N
F
L
D
K
S
G
L
Q
G
Y
D
M
Site 19
Y118
D
K
S
G
L
Q
G
Y
D
M
S
T
F
I
R
Site 20
S121
G
L
Q
G
Y
D
M
S
T
F
I
R
R
Y
S
Site 21
T122
L
Q
G
Y
D
M
S
T
F
I
R
R
Y
S
R
Site 22
Y127
M
S
T
F
I
R
R
Y
S
R
Y
L
N
E
K
Site 23
S128
S
T
F
I
R
R
Y
S
R
Y
L
N
E
K
A
Site 24
Y130
F
I
R
R
Y
S
R
Y
L
N
E
K
A
V
S
Site 25
S137
Y
L
N
E
K
A
V
S
Y
R
Q
V
A
F
D
Site 26
T146
R
Q
V
A
F
D
F
T
K
V
K
R
G
A
D
Site 27
T167
N
T
E
K
L
L
K
T
V
P
I
I
Q
N
Q
Site 28
T189
N
V
N
S
N
E
L
T
N
G
V
I
N
A
A
Site 29
Y222
I
I
N
L
L
E
K
Y
F
D
M
K
K
N
Q
Site 30
Y237
C
K
E
G
L
D
I
Y
K
K
F
L
T
R
M
Site 31
T245
K
K
F
L
T
R
M
T
R
I
S
E
F
L
K
Site 32
S248
L
T
R
M
T
R
I
S
E
F
L
K
V
A
E
Site 33
S268
R
G
D
I
P
D
L
S
Q
A
P
S
S
L
L
Site 34
S272
P
D
L
S
Q
A
P
S
S
L
L
D
A
L
E
Site 35
S273
D
L
S
Q
A
P
S
S
L
L
D
A
L
E
Q
Site 36
S293
E
G
K
K
I
K
D
S
T
A
A
S
R
A
T
Site 37
S297
I
K
D
S
T
A
A
S
R
A
T
T
L
S
N
Site 38
T300
S
T
A
A
S
R
A
T
T
L
S
N
A
V
S
Site 39
T301
T
A
A
S
R
A
T
T
L
S
N
A
V
S
S
Site 40
S303
A
S
R
A
T
T
L
S
N
A
V
S
S
L
A
Site 41
S307
T
T
L
S
N
A
V
S
S
L
A
S
T
G
L
Site 42
T312
A
V
S
S
L
A
S
T
G
L
S
L
T
K
V
Site 43
S315
S
L
A
S
T
G
L
S
L
T
K
V
D
E
R
Site 44
S353
L
A
K
K
P
H
T
S
L
T
T
A
A
S
P
Site 45
T355
K
K
P
H
T
S
L
T
T
A
A
S
P
V
S
Site 46
S378
A
P
A
I
D
I
F
S
T
P
S
S
S
N
S
Site 47
T379
P
A
I
D
I
F
S
T
P
S
S
S
N
S
T
Site 48
S381
I
D
I
F
S
T
P
S
S
S
N
S
T
S
K
Site 49
S382
D
I
F
S
T
P
S
S
S
N
S
T
S
K
L
Site 50
S383
I
F
S
T
P
S
S
S
N
S
T
S
K
L
P
Site 51
S385
S
T
P
S
S
S
N
S
T
S
K
L
P
N
D
Site 52
S387
P
S
S
S
N
S
T
S
K
L
P
N
D
L
L
Site 53
T400
L
L
D
L
Q
Q
P
T
F
H
P
S
V
H
P
Site 54
S404
Q
Q
P
T
F
H
P
S
V
H
P
M
S
T
A
Site 55
S409
H
P
S
V
H
P
M
S
T
A
S
Q
V
A
S
Site 56
S412
V
H
P
M
S
T
A
S
Q
V
A
S
T
W
G
Site 57
S416
S
T
A
S
Q
V
A
S
T
W
G
D
P
F
S
Site 58
S423
S
T
W
G
D
P
F
S
A
T
V
D
A
V
D
Site 59
T441
P
S
L
N
P
F
L
T
K
S
S
G
D
V
H
Site 60
S443
L
N
P
F
L
T
K
S
S
G
D
V
H
L
S
Site 61
S450
S
S
G
D
V
H
L
S
I
S
S
D
V
S
T
Site 62
S456
L
S
I
S
S
D
V
S
T
F
T
T
R
T
P
Site 63
T457
S
I
S
S
D
V
S
T
F
T
T
R
T
P
T
Site 64
T459
S
S
D
V
S
T
F
T
T
R
T
P
T
H
E
Site 65
T460
S
D
V
S
T
F
T
T
R
T
P
T
H
E
M
Site 66
T462
V
S
T
F
T
T
R
T
P
T
H
E
M
F
V
Site 67
T464
T
F
T
T
R
T
P
T
H
E
M
F
V
G
F
Site 68
T472
H
E
M
F
V
G
F
T
P
S
P
V
A
Q
P
Site 69
S474
M
F
V
G
F
T
P
S
P
V
A
Q
P
H
P
Site 70
S491
G
L
N
V
D
F
E
S
V
F
G
N
K
S
T
Site 71
S497
E
S
V
F
G
N
K
S
T
N
V
I
V
D
S
Site 72
S504
S
T
N
V
I
V
D
S
G
G
F
D
E
L
G
Site 73
T517
L
G
G
L
L
K
P
T
V
A
S
Q
N
Q
N
Site 74
S520
L
L
K
P
T
V
A
S
Q
N
Q
N
L
P
V
Site 75
S533
P
V
A
K
L
P
P
S
K
L
V
S
D
D
L
Site 76
S537
L
P
P
S
K
L
V
S
D
D
L
D
S
S
L
Site 77
S543
V
S
D
D
L
D
S
S
L
A
N
L
V
G
N
Site 78
T558
L
G
I
G
N
G
T
T
K
N
D
V
N
W
S
Site 79
S565
T
K
N
D
V
N
W
S
Q
P
G
E
K
K
L
Site 80
T573
Q
P
G
E
K
K
L
T
G
G
S
N
W
Q
P
Site 81
S576
E
K
K
L
T
G
G
S
N
W
Q
P
K
V
A
Site 82
Y611
T
P
T
G
M
I
G
Y
G
I
P
P
Q
M
G
Site 83
S619
G
I
P
P
Q
M
G
S
V
P
V
M
T
Q
P
Site 84
Y630
M
T
Q
P
T
L
I
Y
S
Q
P
V
M
R
P
Site 85
S631
T
Q
P
T
L
I
Y
S
Q
P
V
M
R
P
P
Site 86
S645
P
N
P
F
G
P
V
S
G
A
Q
I
Q
F
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation