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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MTM1
Full Name:
Myotubularin
Alias:
CG2; CNM; EC 3.1.3.48; MTMX; Myotubularin; Myotubularin 1; XLMTM
Type:
EC 3.1.3.48; Phosphatase (non-protein)
Mass (Da):
69932
Number AA:
603
UniProt ID:
Q13496
International Prot ID:
IPI00013427
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0004722
GO:0004725
PhosphoSite+
KinaseNET
Biological Process:
GO:0007517
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
S
A
S
T
S
K
Y
N
S
H
S
L
Site 2
Y9
A
S
A
S
T
S
K
Y
N
S
H
S
L
E
N
Site 3
S11
A
S
T
S
K
Y
N
S
H
S
L
E
N
E
S
Site 4
S13
T
S
K
Y
N
S
H
S
L
E
N
E
S
I
K
Site 5
S18
S
H
S
L
E
N
E
S
I
K
R
T
S
R
D
Site 6
T22
E
N
E
S
I
K
R
T
S
R
D
G
V
N
R
Site 7
S23
N
E
S
I
K
R
T
S
R
D
G
V
N
R
D
Site 8
T32
D
G
V
N
R
D
L
T
E
A
V
P
R
L
P
Site 9
Y64
G
P
I
K
G
R
V
Y
I
T
N
Y
R
L
Y
Site 10
Y71
Y
I
T
N
Y
R
L
Y
L
R
S
L
E
T
D
Site 11
S74
N
Y
R
L
Y
L
R
S
L
E
T
D
S
S
L
Site 12
S91
D
V
P
L
G
V
I
S
R
I
E
K
M
G
G
Site 13
S101
E
K
M
G
G
A
T
S
R
G
E
N
S
Y
G
Site 14
S106
A
T
S
R
G
E
N
S
Y
G
L
D
I
T
C
Site 15
Y107
T
S
R
G
E
N
S
Y
G
L
D
I
T
C
K
Site 16
T112
N
S
Y
G
L
D
I
T
C
K
D
M
R
N
L
Site 17
S129
A
L
K
Q
E
G
H
S
R
R
D
M
F
E
I
Site 18
Y167
N
V
D
G
W
T
V
Y
N
P
V
E
E
Y
R
Site 19
Y173
V
Y
N
P
V
E
E
Y
R
R
Q
G
L
P
N
Site 20
S209
L
V
V
P
Y
R
A
S
D
D
D
L
R
R
V
Site 21
T218
D
D
L
R
R
V
A
T
F
R
S
R
N
R
I
Site 22
S221
R
R
V
A
T
F
R
S
R
N
R
I
P
V
L
Site 23
S229
R
N
R
I
P
V
L
S
W
I
H
P
E
N
K
Site 24
Y260
R
N
K
D
D
E
K
Y
L
D
V
I
R
E
T
Site 25
T267
Y
L
D
V
I
R
E
T
N
K
Q
I
S
K
L
Site 26
Y277
Q
I
S
K
L
T
I
Y
D
A
R
P
S
V
N
Site 27
S282
T
I
Y
D
A
R
P
S
V
N
A
V
A
N
K
Site 28
Y295
N
K
A
T
G
G
G
Y
E
S
D
D
A
Y
H
Site 29
S297
A
T
G
G
G
Y
E
S
D
D
A
Y
H
N
A
Site 30
Y301
G
Y
E
S
D
D
A
Y
H
N
A
E
L
F
F
Site 31
S320
N
I
H
V
M
R
E
S
L
K
K
V
K
D
I
Site 32
Y329
K
K
V
K
D
I
V
Y
P
N
V
E
E
S
H
Site 33
S335
V
Y
P
N
V
E
E
S
H
W
L
S
S
L
E
Site 34
S339
V
E
E
S
H
W
L
S
S
L
E
S
T
H
W
Site 35
S340
E
E
S
H
W
L
S
S
L
E
S
T
H
W
L
Site 36
T344
W
L
S
S
L
E
S
T
H
W
L
E
H
I
K
Site 37
S369
D
K
V
S
S
G
K
S
S
V
L
V
H
C
S
Site 38
S370
K
V
S
S
G
K
S
S
V
L
V
H
C
S
D
Site 39
T382
C
S
D
G
W
D
R
T
A
Q
L
T
S
L
A
Site 40
S413
L
V
Q
K
E
W
I
S
F
G
H
K
F
A
S
Site 41
S420
S
F
G
H
K
F
A
S
R
I
G
H
G
D
K
Site 42
S435
N
H
T
D
A
D
R
S
P
I
F
L
Q
F
I
Site 43
S484
T
F
L
F
N
C
E
S
A
R
E
R
Q
K
V
Site 44
T492
A
R
E
R
Q
K
V
T
E
R
T
V
S
L
W
Site 45
T495
R
Q
K
V
T
E
R
T
V
S
L
W
S
L
I
Site 46
S497
K
V
T
E
R
T
V
S
L
W
S
L
I
N
S
Site 47
S500
E
R
T
V
S
L
W
S
L
I
N
S
N
K
E
Site 48
S504
S
L
W
S
L
I
N
S
N
K
E
K
F
K
N
Site 49
Y514
E
K
F
K
N
P
F
Y
T
K
E
I
N
R
V
Site 50
Y523
K
E
I
N
R
V
L
Y
P
V
A
S
M
R
H
Site 51
Y538
L
E
L
W
V
N
Y
Y
I
R
W
N
P
R
I
Site 52
Y567
L
L
A
L
R
D
E
Y
I
K
R
L
E
E
L
Site 53
S579
E
E
L
Q
L
A
N
S
A
K
L
S
D
P
P
Site 54
S583
L
A
N
S
A
K
L
S
D
P
P
T
S
P
S
Site 55
T587
A
K
L
S
D
P
P
T
S
P
S
S
P
S
Q
Site 56
S588
K
L
S
D
P
P
T
S
P
S
S
P
S
Q
M
Site 57
S590
S
D
P
P
T
S
P
S
S
P
S
Q
M
M
P
Site 58
S591
D
P
P
T
S
P
S
S
P
S
Q
M
M
P
H
Site 59
S593
P
T
S
P
S
S
P
S
Q
M
M
P
H
V
Q
Site 60
T601
Q
M
M
P
H
V
Q
T
H
F
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation