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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SQSTM1
Full Name:
Sequestosome-1
Alias:
EBIAP; ORCA; OSIL; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; Ubiquitin-binding protein p62
Type:
Adapter/scaffold protein
Mass (Da):
47687
Number AA:
440
UniProt ID:
Q13501
International Prot ID:
IPI00783357
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005770
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0042169
GO:0005080
GO:0030971
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0006915
GO:0030154
Phosida
TranscriptoNet
STRING
Kinexus Products
Sequestosome-1 pan-specific antibody AB-NN375-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN375-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
A
S
L
T
V
K
A
Y
L
L
G
K
E
D
A
Site 2
S24
A
R
E
I
R
R
F
S
F
C
C
S
P
E
P
Site 3
S28
R
R
F
S
F
C
C
S
P
E
P
E
A
E
A
Site 4
S49
G
P
C
E
R
L
L
S
R
V
A
A
L
F
P
Site 5
Y67
P
G
G
F
Q
A
H
Y
R
D
E
D
G
D
L
Site 6
S78
D
G
D
L
V
A
F
S
S
D
E
E
L
T
M
Site 7
T84
F
S
S
D
E
E
L
T
M
A
M
S
Y
V
K
Site 8
S88
E
E
L
T
M
A
M
S
Y
V
K
D
D
I
F
Site 9
Y89
E
L
T
M
A
M
S
Y
V
K
D
D
I
F
R
Site 10
Y98
K
D
D
I
F
R
I
Y
I
K
E
K
K
E
C
Site 11
Y140
G
P
V
V
G
T
R
Y
K
C
S
V
C
P
D
Site 12
Y148
K
C
S
V
C
P
D
Y
D
L
C
S
V
C
E
Site 13
T164
K
G
L
H
R
G
H
T
K
L
A
F
P
S
P
Site 14
S170
H
T
K
L
A
F
P
S
P
F
G
H
L
S
E
Site 15
S176
P
S
P
F
G
H
L
S
E
G
F
S
H
S
R
Site 16
S180
G
H
L
S
E
G
F
S
H
S
R
W
L
R
K
Site 17
S182
L
S
E
G
F
S
H
S
R
W
L
R
K
V
K
Site 18
S207
M
G
P
P
G
N
W
S
P
R
P
P
R
A
G
Site 19
S224
R
P
G
P
T
A
E
S
A
S
G
P
S
E
D
Site 20
S226
G
P
T
A
E
S
A
S
G
P
S
E
D
P
S
Site 21
S229
A
E
S
A
S
G
P
S
E
D
P
S
V
N
F
Site 22
S233
S
G
P
S
E
D
P
S
V
N
F
L
K
N
V
Site 23
S249
E
S
V
A
A
A
L
S
P
L
G
I
E
V
D
Site 24
S266
V
E
H
G
G
K
R
S
R
L
T
P
V
S
P
Site 25
T269
G
G
K
R
S
R
L
T
P
V
S
P
E
S
S
Site 26
S272
R
S
R
L
T
P
V
S
P
E
S
S
S
T
E
Site 27
S275
L
T
P
V
S
P
E
S
S
S
T
E
E
K
S
Site 28
S276
T
P
V
S
P
E
S
S
S
T
E
E
K
S
S
Site 29
S277
P
V
S
P
E
S
S
S
T
E
E
K
S
S
S
Site 30
T278
V
S
P
E
S
S
S
T
E
E
K
S
S
S
Q
Site 31
S282
S
S
S
T
E
E
K
S
S
S
Q
P
S
S
C
Site 32
S283
S
S
T
E
E
K
S
S
S
Q
P
S
S
C
C
Site 33
S284
S
T
E
E
K
S
S
S
Q
P
S
S
C
C
S
Site 34
S287
E
K
S
S
S
Q
P
S
S
C
C
S
D
P
S
Site 35
S288
K
S
S
S
Q
P
S
S
C
C
S
D
P
S
K
Site 36
S291
S
Q
P
S
S
C
C
S
D
P
S
K
P
G
G
Site 37
S294
S
S
C
C
S
D
P
S
K
P
G
G
N
V
E
Site 38
S306
N
V
E
G
A
T
Q
S
L
A
E
Q
M
R
K
Site 39
S318
M
R
K
I
A
L
E
S
E
G
R
P
E
E
Q
Site 40
S328
R
P
E
E
Q
M
E
S
D
N
C
S
G
G
D
Site 41
S332
Q
M
E
S
D
N
C
S
G
G
D
D
D
W
T
Site 42
T339
S
G
G
D
D
D
W
T
H
L
S
S
K
E
V
Site 43
S342
D
D
D
W
T
H
L
S
S
K
E
V
D
P
S
Site 44
S343
D
D
W
T
H
L
S
S
K
E
V
D
P
S
T
Site 45
S349
S
S
K
E
V
D
P
S
T
G
E
L
Q
S
L
Site 46
T350
S
K
E
V
D
P
S
T
G
E
L
Q
S
L
Q
Site 47
S355
P
S
T
G
E
L
Q
S
L
Q
M
P
E
S
E
Site 48
S361
Q
S
L
Q
M
P
E
S
E
G
P
S
S
L
D
Site 49
S365
M
P
E
S
E
G
P
S
S
L
D
P
S
Q
E
Site 50
S366
P
E
S
E
G
P
S
S
L
D
P
S
Q
E
G
Site 51
S370
G
P
S
S
L
D
P
S
Q
E
G
P
T
G
L
Site 52
T375
D
P
S
Q
E
G
P
T
G
L
K
E
A
A
L
Site 53
Y383
G
L
K
E
A
A
L
Y
P
H
L
P
P
E
A
Site 54
S397
A
D
P
R
L
I
E
S
L
S
Q
M
L
S
M
Site 55
S403
E
S
L
S
Q
M
L
S
M
G
F
S
D
E
G
Site 56
S407
Q
M
L
S
M
G
F
S
D
E
G
G
W
L
T
Site 57
Y422
R
L
L
Q
T
K
N
Y
D
I
G
A
A
L
D
Site 58
T430
D
I
G
A
A
L
D
T
I
Q
Y
S
K
H
P
Site 59
Y433
A
A
L
D
T
I
Q
Y
S
K
H
P
P
P
L
Site 60
S434
A
L
D
T
I
Q
Y
S
K
H
P
P
P
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation