PhosphoNET

           
Protein Info 
   
Short Name:  PRPF4B
Full Name:  Serine/threonine-protein kinase PRP4 homolog
Alias:  CBP143; EC 2.7.11.1; KIAA0536; Kinase PRP4; PR4H; Pre-mRNA protein kinase; Prp4; PRP4 homolog; PRP4 kinase; PRP4 pre- mRNA processing factor 4 homolog; PRP4 pre-mRNA processing factor 4 B; PRP4B; PRP4H; PRP4K; PRP4M; PRPK
Type:  Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; CMGC group; DYRK family; PRP4 subfamily
Mass (Da):  116973
Number AA:  1007
UniProt ID:  Q13523
International Prot ID:  IPI00013721
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005681  GO:0005681  GO:0005694 Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0005515  GO:0004674 PhosphoSite+ KinaseNET
Biological Process:  GO:0008380  GO:0006397  GO:0006468 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S8MAAAETQSLREQPEM
Site 2S20PEMEDANSEKSINEE
Site 3S23EDANSEKSINEENGE
Site 4S32NEENGEVSEDQSQNK
Site 5S36GEVSEDQSQNKHSRH
Site 6S52KKKHKHRSKHKKHKH
Site 7S61HKKHKHSSEEDKDKK
Site 8S87RKEVIDASDKEGMSP
Site 9S93ASDKEGMSPAKRTKL
Site 10Y140MGLILQGYESGSEEE
Site 11S142LILQGYESGSEEEGE
Site 12S144LQGYESGSEEEGEIH
Site 13S160KARNGNRSSTRSSST
Site 14S161ARNGNRSSTRSSSTK
Site 15T162RNGNRSSTRSSSTKG
Site 16S164GNRSSTRSSSTKGKL
Site 17S165NRSSTRSSSTKGKLE
Site 18S166RSSTRSSSTKGKLEL
Site 19T167SSTRSSSTKGKLELV
Site 20T180LVDNKITTKKRSKSR
Site 21S184KITTKKRSKSRSKER
Site 22S186TTKKRSKSRSKERTR
Site 23S188KKRSKSRSKERTRHR
Site 24T192KSRSKERTRHRSDKK
Site 25S196KERTRHRSDKKKSKG
Site 26S201HRSDKKKSKGGIEIV
Site 27T212IEIVKEKTTRSKSKE
Site 28S215VKEKTTRSKSKERKK
Site 29S217EKTTRSKSKERKKSK
Site 30S223KSKERKKSKSPSKRS
Site 31S225KERKKSKSPSKRSKS
Site 32S227RKKSKSPSKRSKSQD
Site 33S232SPSKRSKSQDQARKS
Site 34S239SQDQARKSKSPTLRR
Site 35S241DQARKSKSPTLRRRS
Site 36T243ARKSKSPTLRRRSQE
Site 37S248SPTLRRRSQEKIGKA
Site 38S257EKIGKARSPTDDKVK
Site 39T259IGKARSPTDDKVKIE
Site 40S269KVKIEDKSKSKDRKK
Site 41S271KIEDKSKSKDRKKSP
Site 42S277KSKDRKKSPIINESR
Site 43S283KSPIINESRSRDRGK
Site 44S285PIINESRSRDRGKKS
Site 45S292SRDRGKKSRSPVDLR
Site 46S294DRGKKSRSPVDLRGK
Site 47S302PVDLRGKSKDRRSRS
Site 48S307GKSKDRRSRSKERKS
Site 49S309SKDRRSRSKERKSKR
Site 50S314SRSKERKSKRSETDK
Site 51S317KERKSKRSETDKEKK
Site 52T319RKSKRSETDKEKKPI
Site 53S328KEKKPIKSPSKDASS
Site 54S330KKPIKSPSKDASSGK
Site 55S334KSPSKDASSGKENRS
Site 56S335SPSKDASSGKENRSP
Site 57S341SSGKENRSPSRRPGR
Site 58S343GKENRSPSRRPGRSP
Site 59S349PSRRPGRSPKRRSLS
Site 60S354GRSPKRRSLSPKPRD
Site 61S356SPKRRSLSPKPRDKS
Site 62S363SPKPRDKSRRSRSPL
Site 63S366PRDKSRRSRSPLLND
Site 64S368DKSRRSRSPLLNDRR
Site 65S376PLLNDRRSKQSKSPS
Site 66S379NDRRSKQSKSPSRTL
Site 67S381RRSKQSKSPSRTLSP
Site 68S383SKQSKSPSRTLSPGR
Site 69T385QSKSPSRTLSPGRRA
Site 70S387KSPSRTLSPGRRAKS
Site 71S394SPGRRAKSRSLERKR
Site 72S396GRRAKSRSLERKRRE
Site 73S410EPERRRLSSPRTRPR
Site 74S411PERRRLSSPRTRPRD
Site 75T414RRLSSPRTRPRDDIL
Site 76S422RPRDDILSRRERSKD
Site 77S427ILSRRERSKDASPIN
Site 78S431RERSKDASPINRWSP
Site 79S437ASPINRWSPTRRRSR
Site 80T439PINRWSPTRRRSRSP
Site 81S443WSPTRRRSRSPIRRR
Site 82S445PTRRRSRSPIRRRSR
Site 83S451RSPIRRRSRSPLRRS
Site 84S453PIRRRSRSPLRRSRS
Site 85S458SRSPLRRSRSPRRRS
Site 86S460SPLRRSRSPRRRSRS
Site 87S465SRSPRRRSRSPRRRD
Site 88S467SPRRRSRSPRRRDRG
Site 89S477RRDRGRRSRSRLRRR
Site 90S479DRGRRSRSRLRRRSR
Site 91S485RSRLRRRSRSRGGRR
Site 92S487RLRRRSRSRGGRRRR
Site 93S495RGGRRRRSRSKVKED
Site 94S497GRRRRSRSKVKEDKF
Site 95S507KEDKFKGSLSEGMKV
Site 96S509DKFKGSLSEGMKVEQ
Site 97S518GMKVEQESSSDDNLE
Site 98S519MKVEQESSSDDNLED
Site 99S520KVEQESSSDDNLEDF
Site 100Y552RQAIVQKYKYLAEDS
Site 101Y554AIVQKYKYLAEDSNM
Site 102S559YKYLAEDSNMSVPSE
Site 103S562LAEDSNMSVPSEPSS
Site 104S565DSNMSVPSEPSSPQS
Site 105S568MSVPSEPSSPQSSTR
Site 106S569SVPSEPSSPQSSTRT
Site 107S572SEPSSPQSSTRTRSP
Site 108S573EPSSPQSSTRTRSPS
Site 109T574PSSPQSSTRTRSPSP
Site 110T576SPQSSTRTRSPSPDD
Site 111S578QSSTRTRSPSPDDIL
Site 112S580STRTRSPSPDDILER
Site 113T602YERENVDTFEASVKA
Site 114T615KAKHNLMTVEQNNGS
Site 115S622TVEQNNGSSQKKLLA
Site 116S623VEQNNGSSQKKLLAP
Site 117S636APDMFTESDDMFAAY
Site 118Y643SDDMFAAYFDSARLR
Site 119T669PNLRDNWTDAEGYYR
Site 120Y674NWTDAEGYYRVNIGE
Site 121Y675WTDAEGYYRVNIGEV
Site 122Y687GEVLDKRYNVYGYTG
Site 123Y690LDKRYNVYGYTGQGV
Site 124S699YTGQGVFSNVVRARD
Site 125Y758LRLFRHFYHKQHLCL
Site 126Y781LREVLKKYGKDVGLH
Site 127S794LHIKAVRSYSQQLFL
Site 128Y795HIKAVRSYSQQLFLA
Site 129S837LKLCDFGSASHVADN
Site 130S839LCDFGSASHVADNDI
Site 131T847HVADNDITPYLVSRF
Site 132Y849ADNDITPYLVSRFYR
Site 133S852DITPYLVSRFYRAPE
Site 134Y855PYLVSRFYRAPEIII
Site 135Y866EIIIGKSYDYGIDMW
Site 136T893KILFPGKTNNHMLKL
Site 137T938YIEVDKVTEREKVTV
Site 138S993LDPAKRISINQALQH
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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