KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
Polycystin 2
Full Name:
Polycystin-2
Alias:
Polycystin-2: Polycystic kidney disease 2 protein: Autosomal dominant polycystic kidney disease type II protein: Polycystwin: R48321
Type:
Channel protein
Mass (Da):
109691
Number AA:
968
UniProt ID:
Q13563
International Prot ID:
IPI00299040
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015629
GO:0016021
GO:0005932
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0008092
GO:0008022
PhosphoSite+
KinaseNET
Biological Process:
GO:0007160
GO:0009887
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S74
P
P
A
G
A
A
A
S
P
S
P
P
L
S
S
Site 2
S76
A
G
A
A
A
S
P
S
P
P
L
S
S
C
S
Site 3
S80
A
S
P
S
P
P
L
S
S
C
S
R
Q
A
W
Site 4
S81
S
P
S
P
P
L
S
S
C
S
R
Q
A
W
S
Site 5
S83
S
P
P
L
S
S
C
S
R
Q
A
W
S
R
D
Site 6
S122
D
V
E
W
R
P
G
S
R
R
S
A
A
S
S
Site 7
S125
W
R
P
G
S
R
R
S
A
A
S
S
A
V
S
Site 8
S128
G
S
R
R
S
A
A
S
S
A
V
S
S
V
G
Site 9
S129
S
R
R
S
A
A
S
S
A
V
S
S
V
G
A
Site 10
S132
S
A
A
S
S
A
V
S
S
V
G
A
R
S
R
Site 11
S133
A
A
S
S
A
V
S
S
V
G
A
R
S
R
G
Site 12
S138
V
S
S
V
G
A
R
S
R
G
L
G
G
Y
H
Site 13
Y144
R
S
R
G
L
G
G
Y
H
G
A
G
H
P
S
Site 14
S151
Y
H
G
A
G
H
P
S
G
R
R
R
R
R
E
Site 15
S166
D
Q
G
P
P
C
P
S
P
V
G
G
G
D
P
Site 16
T203
G
L
R
G
L
W
G
T
R
L
M
E
E
S
S
Site 17
S209
G
T
R
L
M
E
E
S
S
T
N
R
E
K
Y
Site 18
S210
T
R
L
M
E
E
S
S
T
N
R
E
K
Y
L
Site 19
T211
R
L
M
E
E
S
S
T
N
R
E
K
Y
L
K
Site 20
Y216
S
S
T
N
R
E
K
Y
L
K
S
V
L
R
E
Site 21
S219
N
R
E
K
Y
L
K
S
V
L
R
E
L
V
T
Site 22
Y247
G
M
M
S
S
N
V
Y
Y
Y
T
R
M
M
S
Site 23
Y248
M
M
S
S
N
V
Y
Y
Y
T
R
M
M
S
Q
Site 24
Y249
M
S
S
N
V
Y
Y
Y
T
R
M
M
S
Q
L
Site 25
S254
Y
Y
Y
T
R
M
M
S
Q
L
F
L
D
T
P
Site 26
T260
M
S
Q
L
F
L
D
T
P
V
S
K
T
E
K
Site 27
S263
L
F
L
D
T
P
V
S
K
T
E
K
T
N
F
Site 28
T268
P
V
S
K
T
E
K
T
N
F
K
T
L
S
S
Site 29
T272
T
E
K
T
N
F
K
T
L
S
S
M
E
D
F
Site 30
S274
K
T
N
F
K
T
L
S
S
M
E
D
F
W
K
Site 31
Y292
G
S
L
L
D
G
L
Y
W
K
M
Q
P
S
N
Site 32
S307
Q
T
E
A
D
N
R
S
F
I
F
Y
E
N
L
Site 33
S330
Q
L
R
V
R
N
G
S
C
S
I
P
Q
D
L
Site 34
S332
R
V
R
N
G
S
C
S
I
P
Q
D
L
R
D
Site 35
Y345
R
D
E
I
K
E
C
Y
D
V
Y
S
V
S
S
Site 36
Y348
I
K
E
C
Y
D
V
Y
S
V
S
S
E
D
R
Site 37
S349
K
E
C
Y
D
V
Y
S
V
S
S
E
D
R
A
Site 38
S351
C
Y
D
V
Y
S
V
S
S
E
D
R
A
P
F
Site 39
T364
P
F
G
P
R
N
G
T
A
W
I
Y
T
S
E
Site 40
Y368
R
N
G
T
A
W
I
Y
T
S
E
K
D
L
N
Site 41
Y391
A
T
Y
S
G
A
G
Y
Y
L
D
L
S
R
T
Site 42
Y392
T
Y
S
G
A
G
Y
Y
L
D
L
S
R
T
R
Site 43
S396
A
G
Y
Y
L
D
L
S
R
T
R
E
E
T
A
Site 44
T402
L
S
R
T
R
E
E
T
A
A
Q
V
A
S
L
Site 45
S408
E
T
A
A
Q
V
A
S
L
K
K
N
V
W
L
Site 46
T422
L
D
R
G
T
R
A
T
F
I
D
F
S
V
Y
Site 47
S454
A
T
G
G
V
I
P
S
W
Q
F
Q
P
L
K
Site 48
T544
Q
F
L
E
D
Q
N
T
F
P
N
F
E
H
L
Site 49
T582
K
F
I
N
F
N
R
T
M
S
Q
L
S
T
T
Site 50
S584
I
N
F
N
R
T
M
S
Q
L
S
T
T
M
S
Site 51
S587
N
R
T
M
S
Q
L
S
T
T
M
S
R
C
A
Site 52
T588
R
T
M
S
Q
L
S
T
T
M
S
R
C
A
K
Site 53
S591
S
Q
L
S
T
T
M
S
R
C
A
K
D
L
F
Site 54
T683
F
L
A
I
I
N
D
T
Y
S
E
V
K
S
D
Site 55
Y684
L
A
I
I
N
D
T
Y
S
E
V
K
S
D
L
Site 56
S685
A
I
I
N
D
T
Y
S
E
V
K
S
D
L
A
Site 57
S689
D
T
Y
S
E
V
K
S
D
L
A
Q
Q
K
A
Site 58
S701
Q
K
A
E
M
E
L
S
D
L
I
R
K
G
Y
Site 59
Y708
S
D
L
I
R
K
G
Y
H
K
A
L
V
K
L
Site 60
T721
K
L
K
L
K
K
N
T
V
D
D
I
S
E
S
Site 61
S726
K
N
T
V
D
D
I
S
E
S
L
R
Q
G
G
Site 62
S728
T
V
D
D
I
S
E
S
L
R
Q
G
G
G
K
Site 63
T760
A
E
I
E
A
I
F
T
K
Y
D
Q
D
G
D
Site 64
Y762
I
E
A
I
F
T
K
Y
D
Q
D
G
D
Q
E
Site 65
S794
E
D
L
D
L
D
H
S
S
L
P
R
P
M
S
Site 66
S795
D
L
D
L
D
H
S
S
L
P
R
P
M
S
S
Site 67
S801
S
S
L
P
R
P
M
S
S
R
S
F
P
R
S
Site 68
S802
S
L
P
R
P
M
S
S
R
S
F
P
R
S
L
Site 69
S804
P
R
P
M
S
S
R
S
F
P
R
S
L
D
D
Site 70
S808
S
S
R
S
F
P
R
S
L
D
D
S
E
E
D
Site 71
S812
F
P
R
S
L
D
D
S
E
E
D
D
D
E
D
Site 72
S820
E
E
D
D
D
E
D
S
G
H
S
S
R
R
R
Site 73
S823
D
D
E
D
S
G
H
S
S
R
R
R
G
S
I
Site 74
S824
D
E
D
S
G
H
S
S
R
R
R
G
S
I
S
Site 75
S829
H
S
S
R
R
R
G
S
I
S
S
G
V
S
Y
Site 76
S831
S
R
R
R
G
S
I
S
S
G
V
S
Y
E
E
Site 77
S832
R
R
R
G
S
I
S
S
G
V
S
Y
E
E
F
Site 78
S835
G
S
I
S
S
G
V
S
Y
E
E
F
Q
V
L
Site 79
S852
R
V
D
R
M
E
H
S
I
G
S
I
V
S
K
Site 80
S855
R
M
E
H
S
I
G
S
I
V
S
K
I
D
A
Site 81
S898
D
E
R
L
G
R
D
S
E
I
H
R
E
Q
M
Site 82
S918
E
E
L
E
R
W
E
S
D
D
A
A
S
Q
I
Site 83
S923
W
E
S
D
D
A
A
S
Q
I
S
H
G
L
G
Site 84
T931
Q
I
S
H
G
L
G
T
P
V
G
L
N
G
Q
Site 85
S943
N
G
Q
P
R
P
R
S
S
R
P
S
S
S
Q
Site 86
S944
G
Q
P
R
P
R
S
S
R
P
S
S
S
Q
S
Site 87
S947
R
P
R
S
S
R
P
S
S
S
Q
S
T
E
G
Site 88
S948
P
R
S
S
R
P
S
S
S
Q
S
T
E
G
M
Site 89
S949
R
S
S
R
P
S
S
S
Q
S
T
E
G
M
E
Site 90
S951
S
R
P
S
S
S
Q
S
T
E
G
M
E
G
A
Site 91
T952
R
P
S
S
S
Q
S
T
E
G
M
E
G
A
G
Site 92
S963
E
G
A
G
G
N
G
S
S
N
V
H
V
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation