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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
APPBP1
Full Name:
NEDD8-activating enzyme E1 regulatory subunit
Alias:
Amyloid beta precursor protein-binding protein 1, 59 kDa; Amyloid protein-binding 1; APP-BP1; HPP1; NEDD8 activating enzyme E1 subunit 1; NEDD8-activating enzyme E1 subunit; Protooncogene protein 1; ULA1; Ula-1
Type:
Ubiquitin conjugating system
Mass (Da):
60250
Number AA:
UniProt ID:
Q13564
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005626
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0046982
PhosphoSite+
KinaseNET
Biological Process:
GO:0006260
GO:0031574
GO:0006915
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
K
L
L
K
E
Q
K
Y
D
R
Q
L
R
L
W
Site 2
S66
I
I
D
G
N
Q
V
S
G
E
D
A
G
N
N
Site 3
S80
N
F
F
L
Q
R
S
S
I
G
K
N
R
A
E
Site 4
S98
E
F
L
Q
E
L
N
S
D
V
S
G
S
F
V
Site 5
S101
Q
E
L
N
S
D
V
S
G
S
F
V
E
E
S
Site 6
S103
L
N
S
D
V
S
G
S
F
V
E
E
S
P
E
Site 7
S108
S
G
S
F
V
E
E
S
P
E
N
L
L
D
N
Site 8
S134
V
A
T
Q
L
P
E
S
T
S
L
R
L
A
D
Site 9
S136
T
Q
L
P
E
S
T
S
L
R
L
A
D
V
L
Site 10
S198
E
L
R
E
H
F
Q
S
Y
D
L
D
H
M
E
Site 11
T212
E
K
K
D
H
S
H
T
P
W
I
V
I
I
A
Site 12
Y221
W
I
V
I
I
A
K
Y
L
A
Q
W
Y
S
E
Site 13
Y226
A
K
Y
L
A
Q
W
Y
S
E
T
N
G
R
I
Site 14
T236
T
N
G
R
I
P
K
T
Y
K
E
K
E
D
F
Site 15
Y237
N
G
R
I
P
K
T
Y
K
E
K
E
D
F
R
Site 16
T279
V
N
T
A
L
N
T
T
Q
I
P
S
S
I
E
Site 17
S284
N
T
T
Q
I
P
S
S
I
E
D
I
F
N
D
Site 18
S303
N
I
T
K
Q
T
P
S
F
W
I
L
A
R
A
Site 19
S336
I
P
D
M
I
A
D
S
G
K
Y
I
K
L
Q
Site 20
Y339
M
I
A
D
S
G
K
Y
I
K
L
Q
N
V
Y
Site 21
Y346
Y
I
K
L
Q
N
V
Y
R
E
K
A
K
K
D
Site 22
S374
S
I
G
Q
A
P
E
S
I
S
E
K
E
L
K
Site 23
S397
L
R
V
V
R
C
R
S
L
A
E
E
Y
G
L
Site 24
T406
A
E
E
Y
G
L
D
T
I
N
K
D
E
I
I
Site 25
S415
N
K
D
E
I
I
S
S
M
D
N
P
D
N
E
Site 26
Y442
F
H
K
Q
Q
G
R
Y
P
G
V
S
N
Y
Q
Site 27
S446
Q
G
R
Y
P
G
V
S
N
Y
Q
V
E
E
D
Site 28
Y448
R
Y
P
G
V
S
N
Y
Q
V
E
E
D
I
G
Site 29
S459
E
D
I
G
K
L
K
S
C
L
T
G
F
L
Q
Site 30
T462
G
K
L
K
S
C
L
T
G
F
L
Q
E
Y
G
Site 31
Y478
S
V
M
V
K
D
D
Y
V
H
E
F
C
R
Y
Site 32
Y485
Y
V
H
E
F
C
R
Y
G
A
A
E
P
H
T
Site 33
S526
T
Y
I
Y
S
G
M
S
Q
T
S
A
T
F
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation