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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TDG
Full Name:
G/T mismatch-specific thymine DNA glycosylase
Alias:
Thymine-DNA glycosylase
Type:
Mass (Da):
46053
Number AA:
410
UniProt ID:
Q13569
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
A
E
N
A
G
S
Y
S
L
Q
Q
A
Q
A
F
Site 2
Y18
L
Q
Q
A
Q
A
F
Y
T
F
P
F
Q
Q
L
Site 3
T67
G
R
K
R
K
P
R
T
T
E
P
K
Q
P
V
Site 4
T68
R
K
R
K
P
R
T
T
E
P
K
Q
P
V
E
Site 5
S85
K
P
V
E
S
K
K
S
G
K
S
A
K
S
K
Site 6
S88
E
S
K
K
S
G
K
S
A
K
S
K
E
K
Q
Site 7
S91
K
S
G
K
S
A
K
S
K
E
K
Q
E
K
I
Site 8
T101
K
Q
E
K
I
T
D
T
F
K
V
K
R
K
V
Site 9
S115
V
D
R
F
N
G
V
S
E
A
E
L
L
T
K
Site 10
Y152
A
A
Y
K
G
H
H
Y
P
G
P
G
N
H
F
Site 11
T180
L
N
H
M
D
D
H
T
L
P
G
K
Y
G
I
Site 12
Y185
D
H
T
L
P
G
K
Y
G
I
G
F
T
N
M
Site 13
T197
T
N
M
V
E
R
T
T
P
G
S
K
D
L
S
Site 14
S200
V
E
R
T
T
P
G
S
K
D
L
S
S
K
E
Site 15
S204
T
P
G
S
K
D
L
S
S
K
E
F
R
E
G
Site 16
S205
P
G
S
K
D
L
S
S
K
E
F
R
E
G
G
Site 17
Y222
L
V
Q
K
L
Q
K
Y
Q
P
R
I
A
V
F
Site 18
S239
K
C
I
Y
E
I
F
S
K
E
V
F
G
V
K
Site 19
T262
Q
P
H
K
I
P
D
T
E
T
L
C
Y
V
M
Site 20
T264
H
K
I
P
D
T
E
T
L
C
Y
V
M
P
S
Site 21
Y267
P
D
T
E
T
L
C
Y
V
M
P
S
S
S
A
Site 22
Y289
A
Q
D
K
V
H
Y
Y
I
K
L
K
D
L
R
Site 23
T314
D
V
Q
E
V
Q
Y
T
F
D
L
Q
L
A
Q
Site 24
Y334
M
A
V
K
E
E
K
Y
D
P
G
Y
E
A
A
Site 25
Y338
E
E
K
Y
D
P
G
Y
E
A
A
Y
G
G
A
Site 26
S352
A
Y
G
E
N
P
C
S
S
E
P
C
G
F
S
Site 27
S353
Y
G
E
N
P
C
S
S
E
P
C
G
F
S
S
Site 28
S360
S
E
P
C
G
F
S
S
N
G
L
I
E
S
V
Site 29
S366
S
S
N
G
L
I
E
S
V
E
L
R
G
E
S
Site 30
S373
S
V
E
L
R
G
E
S
A
F
S
G
I
P
N
Site 31
S376
L
R
G
E
S
A
F
S
G
I
P
N
G
Q
W
Site 32
S394
S
F
T
D
Q
I
P
S
F
S
N
H
C
G
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation