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Updated November 2019
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Protein Info
Short Name:
IQGAP2
Full Name:
Ras GTPase-activating-like protein IQGAP2
Alias:
IQ motif containing GTPase activating protein 2; IQGA2
Type:
Intracellular, Actin cytoskeleton protein
Mass (Da):
180613
Number AA:
1575
UniProt ID:
Q13576
International Prot ID:
IPI00299048
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015629
Uniprot
OncoNet
Molecular Function:
GO:0005095
GO:0005099
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
GO:0051056
GO:0007264
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
P
H
E
E
L
P
S
L
Q
R
P
R
Y
G
Site 2
Y14
P
S
L
Q
R
P
R
Y
G
S
I
V
D
D
E
Site 3
S16
L
Q
R
P
R
Y
G
S
I
V
D
D
E
R
L
Site 4
S24
I
V
D
D
E
R
L
S
A
E
E
M
D
E
R
Site 5
Y38
R
R
R
Q
N
I
A
Y
E
Y
L
C
H
L
E
Site 6
Y40
R
Q
N
I
A
Y
E
Y
L
C
H
L
E
E
A
Site 7
T62
L
V
E
E
L
P
P
T
T
E
L
E
E
G
L
Site 8
Y93
M
V
S
E
K
K
I
Y
D
V
E
Q
T
R
Y
Site 9
Y100
Y
D
V
E
Q
T
R
Y
K
K
S
G
L
H
F
Site 10
S103
E
Q
T
R
Y
K
K
S
G
L
H
F
R
H
T
Site 11
T110
S
G
L
H
F
R
H
T
D
N
T
V
Q
W
L
Site 12
S122
Q
W
L
R
A
M
E
S
I
G
L
P
K
I
F
Site 13
T133
P
K
I
F
Y
P
E
T
T
D
V
Y
D
R
K
Site 14
Y137
Y
P
E
T
T
D
V
Y
D
R
K
N
I
P
R
Site 15
T175
L
L
G
K
V
D
F
T
E
E
E
I
S
N
M
Site 16
S180
D
F
T
E
E
E
I
S
N
M
R
K
E
L
E
Site 17
Y189
M
R
K
E
L
E
K
Y
G
I
Q
M
P
S
F
Site 18
S195
K
Y
G
I
Q
M
P
S
F
S
K
I
G
G
I
Site 19
S197
G
I
Q
M
P
S
F
S
K
I
G
G
I
L
A
Site 20
T233
E
K
G
I
A
E
Q
T
V
V
T
L
R
N
P
Site 21
T245
R
N
P
N
A
V
L
T
L
V
D
D
N
L
A
Site 22
Y255
D
D
N
L
A
P
E
Y
Q
K
E
L
W
D
A
Site 23
S275
E
N
A
R
L
K
N
S
C
I
S
E
E
E
R
Site 24
Y285
S
E
E
E
R
D
A
Y
E
E
L
L
T
Q
A
Site 25
T290
D
A
Y
E
E
L
L
T
Q
A
E
I
Q
G
N
Site 26
Y359
Q
K
Q
N
T
M
N
Y
L
A
H
E
E
L
L
Site 27
S389
L
E
S
N
D
L
V
S
V
Q
N
Q
L
R
S
Site 28
S396
S
V
Q
N
Q
L
R
S
P
A
I
G
L
N
N
Site 29
Y408
L
N
N
L
D
K
A
Y
V
E
R
Y
A
N
T
Site 30
S425
S
V
K
L
E
V
L
S
Q
G
Q
D
N
L
S
Site 31
Y494
D
P
A
H
A
Q
H
Y
Q
D
V
L
Y
H
A
Site 32
Y499
Q
H
Y
Q
D
V
L
Y
H
A
K
S
Q
K
L
Site 33
S503
D
V
L
Y
H
A
K
S
Q
K
L
G
D
S
E
Site 34
S509
K
S
Q
K
L
G
D
S
E
S
V
S
K
V
L
Site 35
S511
Q
K
L
G
D
S
E
S
V
S
K
V
L
W
L
Site 36
S513
L
G
D
S
E
S
V
S
K
V
L
W
L
D
E
Site 37
S554
Q
C
L
E
G
K
K
S
S
D
I
L
S
V
L
Site 38
S555
C
L
E
G
K
K
S
S
D
I
L
S
V
L
K
Site 39
S559
K
K
S
S
D
I
L
S
V
L
K
S
S
T
S
Site 40
S563
D
I
L
S
V
L
K
S
S
T
S
N
A
N
D
Site 41
S566
S
V
L
K
S
S
T
S
N
A
N
D
I
I
P
Site 42
Y579
I
P
E
C
A
D
K
Y
Y
D
A
L
V
K
A
Site 43
Y580
P
E
C
A
D
K
Y
Y
D
A
L
V
K
A
K
Site 44
S591
V
K
A
K
E
L
K
S
E
R
V
S
S
D
G
Site 45
S595
E
L
K
S
E
R
V
S
S
D
G
S
W
L
K
Site 46
S596
L
K
S
E
R
V
S
S
D
G
S
W
L
K
L
Site 47
S599
E
R
V
S
S
D
G
S
W
L
K
L
N
L
H
Site 48
Y609
K
L
N
L
H
K
K
Y
D
Y
Y
Y
N
T
D
Site 49
Y611
N
L
H
K
K
Y
D
Y
Y
Y
N
T
D
S
K
Site 50
Y612
L
H
K
K
Y
D
Y
Y
Y
N
T
D
S
K
E
Site 51
Y613
H
K
K
Y
D
Y
Y
Y
N
T
D
S
K
E
S
Site 52
S621
N
T
D
S
K
E
S
S
W
V
T
P
E
S
C
Site 53
T624
S
K
E
S
S
W
V
T
P
E
S
C
F
Y
K
Site 54
Y630
V
T
P
E
S
C
F
Y
K
E
S
W
L
T
G
Site 55
T636
F
Y
K
E
S
W
L
T
G
K
E
I
E
D
I
Site 56
Y651
I
E
E
V
T
V
G
Y
I
R
E
N
I
W
S
Site 57
S658
Y
I
R
E
N
I
W
S
A
S
E
E
L
L
L
Site 58
S660
R
E
N
I
W
S
A
S
E
E
L
L
L
R
F
Site 59
S671
L
L
R
F
Q
A
T
S
S
G
P
I
L
R
E
Site 60
S672
L
R
F
Q
A
T
S
S
G
P
I
L
R
E
E
Site 61
S685
E
E
F
E
A
R
K
S
F
L
H
E
Q
E
E
Site 62
Y710
G
Y
K
Q
R
K
E
Y
M
H
R
R
Q
T
F
Site 63
T716
E
Y
M
H
R
R
Q
T
F
I
D
N
T
D
S
Site 64
T721
R
Q
T
F
I
D
N
T
D
S
V
V
K
I
Q
Site 65
T735
Q
S
W
F
R
M
A
T
A
R
K
S
Y
L
S
Site 66
S739
R
M
A
T
A
R
K
S
Y
L
S
R
L
Q
Y
Site 67
Y740
M
A
T
A
R
K
S
Y
L
S
R
L
Q
Y
F
Site 68
S742
T
A
R
K
S
Y
L
S
R
L
Q
Y
F
R
D
Site 69
Y746
S
Y
L
S
R
L
Q
Y
F
R
D
H
N
N
E
Site 70
S759
N
E
I
V
K
I
Q
S
L
L
R
A
N
K
A
Site 71
Y770
A
N
K
A
R
D
D
Y
K
T
L
V
G
S
E
Site 72
T772
K
A
R
D
D
Y
K
T
L
V
G
S
E
N
P
Site 73
T782
G
S
E
N
P
P
L
T
V
I
R
K
F
V
Y
Site 74
S794
F
V
Y
L
L
D
Q
S
D
L
D
F
Q
E
E
Site 75
T813
R
L
R
E
E
V
V
T
K
I
R
A
N
Q
Q
Site 76
S847
I
T
L
E
D
V
I
S
H
S
K
K
L
N
K
Site 77
S873
T
D
N
Q
G
I
K
S
L
S
K
E
R
R
K
Site 78
S875
N
Q
G
I
K
S
L
S
K
E
R
R
K
T
L
Site 79
T881
L
S
K
E
R
R
K
T
L
E
T
Y
Q
Q
L
Site 80
T884
E
R
R
K
T
L
E
T
Y
Q
Q
L
F
Y
L
Site 81
Y885
R
R
K
T
L
E
T
Y
Q
Q
L
F
Y
L
L
Site 82
Y890
E
T
Y
Q
Q
L
F
Y
L
L
Q
T
N
P
L
Site 83
T917
K
S
T
K
F
M
D
T
V
I
F
T
L
Y
N
Site 84
Y923
D
T
V
I
F
T
L
Y
N
Y
A
S
N
Q
R
Site 85
Y933
A
S
N
Q
R
E
E
Y
L
L
L
K
L
F
K
Site 86
S949
A
L
E
E
E
I
K
S
K
V
D
Q
V
Q
D
Site 87
T959
D
Q
V
Q
D
I
V
T
G
N
P
T
V
I
K
Site 88
T980
R
G
A
R
G
Q
N
T
L
R
Q
L
L
A
P
Site 89
S997
K
E
I
I
D
D
K
S
L
I
I
N
T
N
P
Site 90
Y1027
G
E
A
S
K
L
P
Y
D
V
T
T
E
Q
A
Site 91
T1030
S
K
L
P
Y
D
V
T
T
E
Q
A
L
T
Y
Site 92
T1036
V
T
T
E
Q
A
L
T
Y
P
E
V
K
N
K
Site 93
Y1037
T
T
E
Q
A
L
T
Y
P
E
V
K
N
K
L
Site 94
T1055
I
E
N
L
R
R
V
T
D
K
V
L
N
S
I
Site 95
S1064
K
V
L
N
S
I
I
S
S
L
D
L
L
P
Y
Site 96
S1065
V
L
N
S
I
I
S
S
L
D
L
L
P
Y
G
Site 97
Y1105
K
I
V
G
N
L
L
Y
Y
R
Y
M
N
P
A
Site 98
Y1106
I
V
G
N
L
L
Y
Y
R
Y
M
N
P
A
I
Site 99
S1132
T
A
G
G
Q
I
N
S
D
Q
R
R
N
L
G
Site 100
S1140
D
Q
R
R
N
L
G
S
V
A
K
V
L
Q
H
Site 101
S1150
K
V
L
Q
H
A
A
S
N
K
L
F
E
G
E
Site 102
S1162
E
G
E
N
E
H
L
S
S
M
N
N
Y
L
S
Site 103
S1163
G
E
N
E
H
L
S
S
M
N
N
Y
L
S
E
Site 104
Y1167
H
L
S
S
M
N
N
Y
L
S
E
T
Y
Q
E
Site 105
S1169
S
S
M
N
N
Y
L
S
E
T
Y
Q
E
F
R
Site 106
Y1172
N
N
Y
L
S
E
T
Y
Q
E
F
R
K
Y
F
Site 107
Y1178
T
Y
Q
E
F
R
K
Y
F
K
E
A
C
N
V
Site 108
Y1197
E
K
F
N
M
D
K
Y
T
D
L
V
T
V
S
Site 109
T1198
K
F
N
M
D
K
Y
T
D
L
V
T
V
S
K
Site 110
T1202
D
K
Y
T
D
L
V
T
V
S
K
P
V
I
Y
Site 111
S1220
E
E
I
I
S
T
H
S
L
L
L
E
H
Q
D
Site 112
S1238
P
E
K
N
D
L
L
S
E
L
L
G
S
L
G
Site 113
S1271
P
N
K
A
N
T
L
S
Q
L
S
K
T
E
I
Site 114
T1276
T
L
S
Q
L
S
K
T
E
I
S
L
V
L
T
Site 115
S1279
Q
L
S
K
T
E
I
S
L
V
L
T
S
K
Y
Site 116
T1283
T
E
I
S
L
V
L
T
S
K
Y
D
I
E
D
Site 117
S1284
E
I
S
L
V
L
T
S
K
Y
D
I
E
D
G
Site 118
Y1286
S
L
V
L
T
S
K
Y
D
I
E
D
G
E
A
Site 119
S1296
E
D
G
E
A
I
D
S
R
S
L
M
I
K
T
Site 120
S1298
G
E
A
I
D
S
R
S
L
M
I
K
T
K
K
Site 121
T1325
T
L
T
E
I
L
E
T
P
A
T
A
Q
Q
E
Site 122
T1328
E
I
L
E
T
P
A
T
A
Q
Q
E
V
D
H
Site 123
T1337
Q
Q
E
V
D
H
A
T
D
M
V
S
R
A
M
Site 124
S1347
V
S
R
A
M
I
D
S
R
T
P
E
E
M
K
Site 125
T1349
R
A
M
I
D
S
R
T
P
E
E
M
K
H
S
Site 126
S1356
T
P
E
E
M
K
H
S
Q
S
M
I
E
D
A
Site 127
S1358
E
E
M
K
H
S
Q
S
M
I
E
D
A
Q
L
Site 128
T1380
K
I
Q
R
N
L
R
T
L
E
Q
T
G
H
V
Site 129
T1384
N
L
R
T
L
E
Q
T
G
H
V
S
S
E
N
Site 130
S1388
L
E
Q
T
G
H
V
S
S
E
N
K
Y
Q
D
Site 131
S1389
E
Q
T
G
H
V
S
S
E
N
K
Y
Q
D
I
Site 132
Y1393
H
V
S
S
E
N
K
Y
Q
D
I
L
N
E
I
Site 133
Y1410
D
I
R
N
Q
R
I
Y
R
K
L
R
K
A
E
Site 134
Y1435
L
N
K
K
A
A
F
Y
E
E
Q
I
N
Y
Y
Site 135
Y1441
F
Y
E
E
Q
I
N
Y
Y
D
T
Y
I
K
T
Site 136
Y1442
Y
E
E
Q
I
N
Y
Y
D
T
Y
I
K
T
C
Site 137
Y1445
Q
I
N
Y
Y
D
T
Y
I
K
T
C
L
D
N
Site 138
T1458
D
N
L
K
R
K
N
T
R
R
S
I
K
L
D
Site 139
S1461
K
R
K
N
T
R
R
S
I
K
L
D
G
K
G
Site 140
Y1481
K
R
A
K
P
V
K
Y
T
A
A
K
L
H
E
Site 141
Y1545
Q
D
L
L
Q
M
Q
Y
E
G
V
A
V
M
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
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2019 Kinexus Bioinformatics Corporation