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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IQGAP2
Full Name:
GRB2-related adapter protein
Alias:
IQ motif containing GTPase activating protein 2; IQGA2
Type:
Intracellular, Actin cytoskeleton protein
Mass (Da):
180613
Number AA:
1575
UniProt ID:
Q13588
International Prot ID:
IPI00299048
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005070
GO:0005099
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
GO:0007265
GO:0007267
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
E
S
V
A
L
Y
S
F
Q
A
T
E
S
Site 2
S8
M
E
S
V
A
L
Y
S
F
Q
A
T
E
S
D
Site 3
T12
A
L
Y
S
F
Q
A
T
E
S
D
E
L
A
F
Site 4
S14
Y
S
F
Q
A
T
E
S
D
E
L
A
F
N
K
Site 5
T24
L
A
F
N
K
G
D
T
L
K
I
L
N
M
E
Site 6
Y52
E
G
F
I
P
K
N
Y
I
R
V
K
P
H
P
Site 7
Y61
R
V
K
P
H
P
W
Y
S
G
R
I
S
R
Q
Site 8
S62
V
K
P
H
P
W
Y
S
G
R
I
S
R
Q
L
Site 9
S66
P
W
Y
S
G
R
I
S
R
Q
L
A
E
E
I
Site 10
S88
G
A
F
L
I
R
E
S
E
S
S
P
G
E
F
Site 11
S91
L
I
R
E
S
E
S
S
P
G
E
F
S
V
S
Site 12
S96
E
S
S
P
G
E
F
S
V
S
V
N
Y
G
D
Site 13
S98
S
P
G
E
F
S
V
S
V
N
Y
G
D
Q
V
Site 14
S115
F
K
V
L
R
E
A
S
G
K
Y
F
L
W
E
Site 15
Y118
L
R
E
A
S
G
K
Y
F
L
W
E
E
K
F
Site 16
S127
L
W
E
E
K
F
N
S
L
N
E
L
V
D
F
Site 17
Y135
L
N
E
L
V
D
F
Y
R
T
T
T
I
A
K
Site 18
T138
L
V
D
F
Y
R
T
T
T
I
A
K
K
R
Q
Site 19
T139
V
D
F
Y
R
T
T
T
I
A
K
K
R
Q
I
Site 20
S157
D
E
E
P
L
L
K
S
P
G
A
C
F
A
Q
Site 21
S170
A
Q
A
Q
F
D
F
S
A
Q
D
P
S
Q
L
Site 22
S175
D
F
S
A
Q
D
P
S
Q
L
S
F
R
R
G
Site 23
S178
A
Q
D
P
S
Q
L
S
F
R
R
G
D
I
I
Site 24
S210
R
V
G
F
F
P
R
S
Y
V
Q
P
V
H
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation