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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DNASE1L3
Full Name:
Deoxyribonuclease gamma
Alias:
Deoxyribonuclease gamma; DHP2; DNAS1L3; DNase I homolog protein DHP2; DNSL3; EC 3.1.21.-; Liver and spleen DNase; LSD
Type:
Apoptosis, Deoxyribonuclease, Calcium-binding protein
Mass (Da):
35504
Number AA:
305
UniProt ID:
Q13609
International Prot ID:
IPI00014286
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005509
GO:0004536
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S30
I
C
S
F
N
V
R
S
F
G
E
S
K
Q
E
Site 2
S34
N
V
R
S
F
G
E
S
K
Q
E
D
K
N
A
Site 3
S79
M
E
K
L
N
R
N
S
R
R
G
I
T
Y
N
Site 4
T84
R
N
S
R
R
G
I
T
Y
N
Y
V
I
S
S
Site 5
Y85
N
S
R
R
G
I
T
Y
N
Y
V
I
S
S
R
Site 6
Y87
R
R
G
I
T
Y
N
Y
V
I
S
S
R
L
G
Site 7
S90
I
T
Y
N
Y
V
I
S
S
R
L
G
R
N
T
Site 8
T97
S
S
R
L
G
R
N
T
Y
K
E
Q
Y
A
F
Site 9
Y98
S
R
L
G
R
N
T
Y
K
E
Q
Y
A
F
L
Site 10
Y106
K
E
Q
Y
A
F
L
Y
K
E
K
L
V
S
V
Site 11
S112
L
Y
K
E
K
L
V
S
V
K
R
S
Y
H
Y
Site 12
Y117
L
V
S
V
K
R
S
Y
H
Y
H
D
Y
Q
D
Site 13
Y119
S
V
K
R
S
Y
H
Y
H
D
Y
Q
D
G
D
Site 14
Y122
R
S
Y
H
Y
H
D
Y
Q
D
G
D
A
D
V
Site 15
S131
D
G
D
A
D
V
F
S
R
E
P
F
V
V
W
Site 16
T156
F
V
I
I
P
L
H
T
T
P
E
T
S
V
K
Site 17
T157
V
I
I
P
L
H
T
T
P
E
T
S
V
K
E
Site 18
T160
P
L
H
T
T
P
E
T
S
V
K
E
I
D
E
Site 19
S161
L
H
T
T
P
E
T
S
V
K
E
I
D
E
L
Site 20
Y196
D
F
N
A
G
C
S
Y
V
P
K
K
A
W
K
Site 21
T223
L
I
G
D
Q
E
D
T
T
V
K
K
S
T
N
Site 22
T224
I
G
D
Q
E
D
T
T
V
K
K
S
T
N
C
Site 23
Y233
K
K
S
T
N
C
A
Y
D
R
I
V
L
R
G
Site 24
S246
R
G
Q
E
I
V
S
S
V
V
P
K
S
N
S
Site 25
S251
V
S
S
V
V
P
K
S
N
S
V
F
D
F
Q
Site 26
S253
S
V
V
P
K
S
N
S
V
F
D
F
Q
K
A
Site 27
S272
E
E
E
A
L
D
V
S
D
H
F
P
V
E
F
Site 28
S283
P
V
E
F
K
L
Q
S
S
R
A
F
T
N
S
Site 29
T288
L
Q
S
S
R
A
F
T
N
S
K
K
S
V
T
Site 30
S290
S
S
R
A
F
T
N
S
K
K
S
V
T
L
R
Site 31
S293
A
F
T
N
S
K
K
S
V
T
L
R
K
K
T
Site 32
T295
T
N
S
K
K
S
V
T
L
R
K
K
T
K
S
Site 33
T300
S
V
T
L
R
K
K
T
K
S
K
R
S
_
_
Site 34
S302
T
L
R
K
K
T
K
S
K
R
S
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation