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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PWP1
Full Name:
Periodic tryptophan protein 1 homolog
Alias:
Keratinocyte protein IEF SSP 950; Keratinocyte protein IEF SSP 9502
Type:
Histone binding protein
Mass (Da):
55828
Number AA:
501
UniProt ID:
Q13610
International Prot ID:
IPI00014298
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
N
R
S
R
Q
V
T
C
V
A
W
V
R
C
Site 2
T21
R
C
G
V
A
K
E
T
P
D
K
V
E
L
S
Site 3
S28
T
P
D
K
V
E
L
S
K
E
E
V
K
R
L
Site 4
S50
L
Q
E
E
G
G
G
S
D
E
E
E
T
G
S
Site 5
T55
G
G
S
D
E
E
E
T
G
S
P
S
E
D
G
Site 6
S57
S
D
E
E
E
T
G
S
P
S
E
D
G
M
Q
Site 7
S59
E
E
E
T
G
S
P
S
E
D
G
M
Q
S
A
Site 8
S65
P
S
E
D
G
M
Q
S
A
R
T
Q
A
R
P
Site 9
T86
G
D
P
E
D
D
R
T
L
D
D
D
E
L
A
Site 10
Y95
D
D
D
E
L
A
E
Y
D
L
D
K
Y
D
E
Site 11
Y100
A
E
Y
D
L
D
K
Y
D
E
E
G
D
P
D
Site 12
T110
E
G
D
P
D
A
E
T
L
G
E
S
L
L
G
Site 13
T119
G
E
S
L
L
G
L
T
V
Y
G
S
N
D
Q
Site 14
Y121
S
L
L
G
L
T
V
Y
G
S
N
D
Q
D
P
Site 15
S123
L
G
L
T
V
Y
G
S
N
D
Q
D
P
Y
V
Site 16
Y129
G
S
N
D
Q
D
P
Y
V
T
L
K
D
T
E
Site 17
T135
P
Y
V
T
L
K
D
T
E
Q
Y
E
R
E
D
Site 18
Y138
T
L
K
D
T
E
Q
Y
E
R
E
D
F
L
I
Site 19
Y169
C
N
L
E
V
H
V
Y
N
Q
E
E
D
S
F
Site 20
Y177
N
Q
E
E
D
S
F
Y
V
H
H
D
I
L
L
Site 21
S199
E
W
L
N
F
D
P
S
P
D
D
S
T
G
N
Site 22
S203
F
D
P
S
P
D
D
S
T
G
N
Y
I
A
V
Site 23
T204
D
P
S
P
D
D
S
T
G
N
Y
I
A
V
G
Site 24
Y207
P
D
D
S
T
G
N
Y
I
A
V
G
N
M
T
Site 25
T233
D
S
L
E
P
V
F
T
L
G
S
K
L
S
K
Site 26
S236
E
P
V
F
T
L
G
S
K
L
S
K
K
K
K
Site 27
S239
F
T
L
G
S
K
L
S
K
K
K
K
K
K
G
Site 28
S249
K
K
K
K
G
K
K
S
S
S
A
E
G
H
T
Site 29
S250
K
K
K
G
K
K
S
S
S
A
E
G
H
T
D
Site 30
S251
K
K
G
K
K
S
S
S
A
E
G
H
T
D
A
Site 31
S263
T
D
A
V
L
D
L
S
W
N
K
L
I
R
N
Site 32
S294
S
L
G
K
P
A
A
S
L
A
V
H
T
D
K
Site 33
T314
F
H
P
F
E
A
Q
T
L
I
S
G
S
Y
D
Site 34
S317
F
E
A
Q
T
L
I
S
G
S
Y
D
K
S
V
Site 35
S323
I
S
G
S
Y
D
K
S
V
A
L
Y
D
C
R
Site 36
Y327
Y
D
K
S
V
A
L
Y
D
C
R
S
P
D
E
Site 37
S331
V
A
L
Y
D
C
R
S
P
D
E
S
H
R
M
Site 38
T349
S
G
Q
I
E
R
V
T
W
N
H
F
S
P
C
Site 39
S361
S
P
C
H
F
L
A
S
T
D
D
G
F
V
Y
Site 40
T362
P
C
H
F
L
A
S
T
D
D
G
F
V
Y
N
Site 41
Y368
S
T
D
D
G
F
V
Y
N
L
D
A
R
S
D
Site 42
S374
V
Y
N
L
D
A
R
S
D
K
P
I
F
T
L
Site 43
S389
N
A
H
N
D
E
I
S
G
L
D
L
S
S
Q
Site 44
S421
D
I
L
G
D
R
P
S
L
V
H
S
R
D
M
Site 45
S425
D
R
P
S
L
V
H
S
R
D
M
K
M
G
V
Site 46
Y446
C
P
D
L
P
F
I
Y
A
F
G
G
Q
K
E
Site 47
S461
G
L
R
V
W
D
I
S
T
V
S
S
V
N
E
Site 48
S465
W
D
I
S
T
V
S
S
V
N
E
A
F
G
R
Site 49
S480
R
E
R
L
V
L
G
S
A
R
N
S
S
I
S
Site 50
S484
V
L
G
S
A
R
N
S
S
I
S
G
P
F
G
Site 51
S485
L
G
S
A
R
N
S
S
I
S
G
P
F
G
S
Site 52
S487
S
A
R
N
S
S
I
S
G
P
F
G
S
R
S
Site 53
S492
S
I
S
G
P
F
G
S
R
S
S
D
T
P
M
Site 54
S494
S
G
P
F
G
S
R
S
S
D
T
P
M
E
S
Site 55
S495
G
P
F
G
S
R
S
S
D
T
P
M
E
S
_
Site 56
T497
F
G
S
R
S
S
D
T
P
M
E
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation