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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MTMR3
Full Name:
Myotubularin-related protein 3
Alias:
EC 3.1.3.48; FYVE domain-containing dual specificity protein phosphatase 1; FYVE-DSP1; KIAA0371, ZFYVE10; Zinc finger FYVE domain-containing protein 10
Type:
Protein phosphatase, dual specificity
Mass (Da):
133619
Number AA:
1198
UniProt ID:
Q13615
International Prot ID:
IPI00185018
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0019898
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0004722
GO:0004725
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
D
E
E
T
R
H
S
L
E
C
I
Q
A
N
Site 2
S56
E
D
A
I
I
A
L
S
N
Y
R
L
H
I
K
Site 3
S159
R
P
G
E
H
V
T
S
R
F
K
N
E
V
E
Site 4
Y185
I
S
N
I
N
E
K
Y
K
L
C
G
S
Y
P
Site 5
S190
E
K
Y
K
L
C
G
S
Y
P
Q
E
L
I
V
Site 6
Y191
K
Y
K
L
C
G
S
Y
P
Q
E
L
I
V
P
Site 7
S208
I
T
D
K
E
L
E
S
V
S
S
F
R
S
W
Site 8
S210
D
K
E
L
E
S
V
S
S
F
R
S
W
K
R
Site 9
S211
K
E
L
E
S
V
S
S
F
R
S
W
K
R
I
Site 10
S214
E
S
V
S
S
F
R
S
W
K
R
I
P
A
V
Site 11
Y223
K
R
I
P
A
V
I
Y
R
H
Q
S
N
G
A
Site 12
S227
A
V
I
Y
R
H
Q
S
N
G
A
V
I
A
R
Site 13
S256
D
D
E
H
L
V
Q
S
V
A
K
A
C
A
S
Site 14
S263
S
V
A
K
A
C
A
S
D
S
R
S
S
G
S
Site 15
S265
A
K
A
C
A
S
D
S
R
S
S
G
S
K
L
Site 16
S267
A
C
A
S
D
S
R
S
S
G
S
K
L
S
T
Site 17
S268
C
A
S
D
S
R
S
S
G
S
K
L
S
T
R
Site 18
S270
S
D
S
R
S
S
G
S
K
L
S
T
R
N
T
Site 19
S273
R
S
S
G
S
K
L
S
T
R
N
T
S
R
D
Site 20
T274
S
S
G
S
K
L
S
T
R
N
T
S
R
D
F
Site 21
T277
S
K
L
S
T
R
N
T
S
R
D
F
P
N
G
Site 22
S278
K
L
S
T
R
N
T
S
R
D
F
P
N
G
G
Site 23
S288
F
P
N
G
G
D
L
S
D
V
E
F
D
S
S
Site 24
S294
L
S
D
V
E
F
D
S
S
L
S
N
A
S
G
Site 25
S295
S
D
V
E
F
D
S
S
L
S
N
A
S
G
A
Site 26
S297
V
E
F
D
S
S
L
S
N
A
S
G
A
E
S
Site 27
S300
D
S
S
L
S
N
A
S
G
A
E
S
L
A
I
Site 28
S304
S
N
A
S
G
A
E
S
L
A
I
Q
P
Q
K
Site 29
Y320
L
I
L
D
A
R
S
Y
A
A
A
V
A
N
R
Site 30
Y338
G
G
C
E
C
P
E
Y
Y
P
N
C
E
V
V
Site 31
S354
M
G
M
A
N
I
H
S
I
R
R
S
F
Q
S
Site 32
S358
N
I
H
S
I
R
R
S
F
Q
S
L
R
L
L
Site 33
S361
S
I
R
R
S
F
Q
S
L
R
L
L
C
T
Q
Site 34
T367
Q
S
L
R
L
L
C
T
Q
M
P
D
P
G
N
Site 35
S377
P
D
P
G
N
W
L
S
A
L
E
S
T
K
W
Site 36
T420
C
S
D
G
W
D
R
T
P
Q
I
V
A
L
A
Site 37
Y434
A
K
L
L
L
D
P
Y
Y
R
T
I
E
G
F
Site 38
Y435
K
L
L
L
D
P
Y
Y
R
T
I
E
G
F
Q
Site 39
S466
R
C
G
H
G
E
N
S
D
D
L
N
E
R
C
Site 40
S493
L
Q
R
Q
F
P
C
S
F
E
F
N
E
A
F
Site 41
T529
K
E
R
G
E
K
H
T
Q
E
R
T
C
S
V
Site 42
T533
E
K
H
T
Q
E
R
T
C
S
V
W
S
L
L
Site 43
S535
H
T
Q
E
R
T
C
S
V
W
S
L
L
R
A
Site 44
S538
E
R
T
C
S
V
W
S
L
L
R
A
G
N
K
Site 45
Y552
K
A
F
K
N
L
L
Y
S
S
Q
S
E
A
V
Site 46
S554
F
K
N
L
L
Y
S
S
Q
S
E
A
V
L
Y
Site 47
Y561
S
Q
S
E
A
V
L
Y
P
V
C
H
V
R
N
Site 48
S581
A
V
Y
L
P
C
P
S
P
T
T
P
V
D
D
Site 49
T584
L
P
C
P
S
P
T
T
P
V
D
D
S
C
A
Site 50
S589
P
T
T
P
V
D
D
S
C
A
P
Y
P
A
P
Site 51
Y593
V
D
D
S
C
A
P
Y
P
A
P
G
T
S
P
Site 52
T598
A
P
Y
P
A
P
G
T
S
P
D
D
P
P
L
Site 53
S599
P
Y
P
A
P
G
T
S
P
D
D
P
P
L
S
Site 54
S606
S
P
D
D
P
P
L
S
R
L
P
K
T
R
S
Site 55
T611
P
L
S
R
L
P
K
T
R
S
Y
D
N
L
T
Site 56
S613
S
R
L
P
K
T
R
S
Y
D
N
L
T
T
A
Site 57
Y614
R
L
P
K
T
R
S
Y
D
N
L
T
T
A
C
Site 58
T618
T
R
S
Y
D
N
L
T
T
A
C
D
N
T
V
Site 59
T619
R
S
Y
D
N
L
T
T
A
C
D
N
T
V
P
Site 60
T624
L
T
T
A
C
D
N
T
V
P
L
A
S
R
R
Site 61
S629
D
N
T
V
P
L
A
S
R
R
C
S
D
P
S
Site 62
S633
P
L
A
S
R
R
C
S
D
P
S
L
N
E
K
Site 63
S636
S
R
R
C
S
D
P
S
L
N
E
K
W
Q
E
Site 64
S647
K
W
Q
E
H
R
R
S
L
E
L
S
S
L
A
Site 65
S651
H
R
R
S
L
E
L
S
S
L
A
G
P
G
E
Site 66
S652
R
R
S
L
E
L
S
S
L
A
G
P
G
E
D
Site 67
S662
G
P
G
E
D
P
L
S
A
D
S
L
G
K
P
Site 68
S665
E
D
P
L
S
A
D
S
L
G
K
P
T
R
V
Site 69
T670
A
D
S
L
G
K
P
T
R
V
P
G
G
A
E
Site 70
S727
D
P
L
L
E
K
E
S
R
R
K
T
P
E
A
Site 71
T731
E
K
E
S
R
R
K
T
P
E
A
S
A
I
G
Site 72
S752
L
G
D
A
A
L
R
S
H
L
D
M
S
W
P
Site 73
S757
L
R
S
H
L
D
M
S
W
P
L
F
S
Q
G
Site 74
S762
D
M
S
W
P
L
F
S
Q
G
I
S
E
Q
Q
Site 75
S766
P
L
F
S
Q
G
I
S
E
Q
Q
S
G
L
S
Site 76
S770
Q
G
I
S
E
Q
Q
S
G
L
S
V
L
L
S
Site 77
S773
S
E
Q
Q
S
G
L
S
V
L
L
S
S
L
Q
Site 78
S788
V
P
P
R
G
E
D
S
L
E
V
P
V
E
Q
Site 79
Y820
P
V
D
A
K
V
G
Y
G
T
S
Q
S
C
S
Site 80
S823
A
K
V
G
Y
G
T
S
Q
S
C
S
L
L
P
Site 81
S825
V
G
Y
G
T
S
Q
S
C
S
L
L
P
S
Q
Site 82
S827
Y
G
T
S
Q
S
C
S
L
L
P
S
Q
V
P
Site 83
S831
Q
S
C
S
L
L
P
S
Q
V
P
F
E
T
R
Site 84
S844
T
R
G
P
N
V
D
S
S
T
D
M
L
V
E
Site 85
S845
R
G
P
N
V
D
S
S
T
D
M
L
V
E
D
Site 86
S856
L
V
E
D
K
V
K
S
V
S
G
P
Q
G
H
Site 87
S858
E
D
K
V
K
S
V
S
G
P
Q
G
H
H
R
Site 88
S866
G
P
Q
G
H
H
R
S
C
L
V
N
S
G
K
Site 89
S871
H
R
S
C
L
V
N
S
G
K
D
R
L
P
Q
Site 90
T879
G
K
D
R
L
P
Q
T
M
E
P
S
P
S
E
Site 91
S883
L
P
Q
T
M
E
P
S
P
S
E
T
S
L
V
Site 92
S885
Q
T
M
E
P
S
P
S
E
T
S
L
V
E
R
Site 93
S888
E
P
S
P
S
E
T
S
L
V
E
R
P
Q
V
Site 94
S897
V
E
R
P
Q
V
G
S
V
V
H
R
T
S
L
Site 95
S903
G
S
V
V
H
R
T
S
L
G
S
T
L
S
L
Site 96
S906
V
H
R
T
S
L
G
S
T
L
S
L
T
R
S
Site 97
T907
H
R
T
S
L
G
S
T
L
S
L
T
R
S
P
Site 98
S913
S
T
L
S
L
T
R
S
P
C
A
L
P
L
A
Site 99
T934
V
C
N
G
A
P
E
T
E
N
R
A
S
E
Q
Site 100
S939
P
E
T
E
N
R
A
S
E
Q
P
P
G
L
S
Site 101
S946
S
E
Q
P
P
G
L
S
T
L
Q
M
Y
P
T
Site 102
T947
E
Q
P
P
G
L
S
T
L
Q
M
Y
P
T
P
Site 103
Y951
G
L
S
T
L
Q
M
Y
P
T
P
N
G
H
C
Site 104
T953
S
T
L
Q
M
Y
P
T
P
N
G
H
C
A
N
Site 105
S966
A
N
G
E
A
G
R
S
K
D
S
L
S
R
Q
Site 106
S969
E
A
G
R
S
K
D
S
L
S
R
Q
L
S
A
Site 107
S971
G
R
S
K
D
S
L
S
R
Q
L
S
A
M
S
Site 108
S975
D
S
L
S
R
Q
L
S
A
M
S
C
S
S
A
Site 109
S978
S
R
Q
L
S
A
M
S
C
S
S
A
H
L
H
Site 110
S980
Q
L
S
A
M
S
C
S
S
A
H
L
H
S
R
Site 111
S981
L
S
A
M
S
C
S
S
A
H
L
H
S
R
N
Site 112
S996
L
H
H
K
W
L
H
S
H
S
G
R
P
S
A
Site 113
S998
H
K
W
L
H
S
H
S
G
R
P
S
A
T
S
Site 114
S1002
H
S
H
S
G
R
P
S
A
T
S
S
P
D
Q
Site 115
T1004
H
S
G
R
P
S
A
T
S
S
P
D
Q
P
S
Site 116
S1005
S
G
R
P
S
A
T
S
S
P
D
Q
P
S
R
Site 117
S1006
G
R
P
S
A
T
S
S
P
D
Q
P
S
R
S
Site 118
S1011
T
S
S
P
D
Q
P
S
R
S
H
L
D
D
D
Site 119
S1013
S
P
D
Q
P
S
R
S
H
L
D
D
D
G
M
Site 120
Y1023
D
D
D
G
M
S
V
Y
T
D
T
I
Q
Q
R
Site 121
T1026
G
M
S
V
Y
T
D
T
I
Q
Q
R
L
R
Q
Site 122
S1054
K
Q
V
Q
E
L
K
S
R
L
E
S
Q
Y
L
Site 123
S1058
E
L
K
S
R
L
E
S
Q
Y
L
T
S
S
L
Site 124
Y1060
K
S
R
L
E
S
Q
Y
L
T
S
S
L
H
F
Site 125
T1062
R
L
E
S
Q
Y
L
T
S
S
L
H
F
N
G
Site 126
S1064
E
S
Q
Y
L
T
S
S
L
H
F
N
G
D
F
Site 127
T1076
G
D
F
G
D
E
V
T
S
I
P
D
S
E
S
Site 128
S1077
D
F
G
D
E
V
T
S
I
P
D
S
E
S
N
Site 129
S1081
E
V
T
S
I
P
D
S
E
S
N
L
D
Q
N
Site 130
S1083
T
S
I
P
D
S
E
S
N
L
D
Q
N
C
L
Site 131
S1094
Q
N
C
L
S
R
C
S
T
E
I
F
S
E
A
Site 132
T1095
N
C
L
S
R
C
S
T
E
I
F
S
E
A
S
Site 133
S1099
R
C
S
T
E
I
F
S
E
A
S
W
E
Q
V
Site 134
S1161
N
Q
K
V
P
V
P
S
Q
Q
L
F
E
P
S
Site 135
S1168
S
Q
Q
L
F
E
P
S
R
V
C
K
S
C
Y
Site 136
S1173
E
P
S
R
V
C
K
S
C
Y
S
S
L
H
P
Site 137
Y1175
S
R
V
C
K
S
C
Y
S
S
L
H
P
T
S
Site 138
S1176
R
V
C
K
S
C
Y
S
S
L
H
P
T
S
S
Site 139
S1177
V
C
K
S
C
Y
S
S
L
H
P
T
S
S
S
Site 140
T1181
C
Y
S
S
L
H
P
T
S
S
S
I
D
L
E
Site 141
S1182
Y
S
S
L
H
P
T
S
S
S
I
D
L
E
L
Site 142
S1183
S
S
L
H
P
T
S
S
S
I
D
L
E
L
D
Site 143
S1184
S
L
H
P
T
S
S
S
I
D
L
E
L
D
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation