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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CUL1
Full Name:
Cullin-1
Alias:
Type:
Mass (Da):
89661
Number AA:
776
UniProt ID:
Q13616
International Prot ID:
IPI00014310
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000151
GO:0005654
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0019899
PhosphoSite+
KinaseNET
Biological Process:
GO:0000082
GO:0006508
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
S
S
T
R
S
Q
N
P
H
G
L
K
Site 2
Y32
R
A
G
I
Q
Q
V
Y
T
R
Q
S
M
A
K
Site 3
S40
T
R
Q
S
M
A
K
S
R
Y
M
E
L
Y
T
Site 4
Y42
Q
S
M
A
K
S
R
Y
M
E
L
Y
T
H
V
Site 5
Y46
K
S
R
Y
M
E
L
Y
T
H
V
Y
N
Y
C
Site 6
S55
H
V
Y
N
Y
C
T
S
V
H
Q
S
N
Q
A
Site 7
S70
R
G
A
G
V
P
P
S
K
S
K
K
G
Q
T
Site 8
S72
A
G
V
P
P
S
K
S
K
K
G
Q
T
P
G
Site 9
T77
S
K
S
K
K
G
Q
T
P
G
G
A
Q
F
V
Site 10
Y89
Q
F
V
G
L
E
L
Y
K
R
L
K
E
F
L
Site 11
Y99
L
K
E
F
L
K
N
Y
L
T
N
L
L
K
D
Site 12
T101
E
F
L
K
N
Y
L
T
N
L
L
K
D
G
E
Site 13
S114
G
E
D
L
M
D
E
S
V
L
K
F
Y
T
Q
Site 14
Y126
Y
T
Q
Q
W
E
D
Y
R
F
S
S
K
V
L
Site 15
Y157
D
E
G
R
K
G
I
Y
E
I
Y
S
L
A
L
Site 16
T198
R
N
G
E
T
I
N
T
R
L
I
S
G
V
V
Site 17
T226
F
A
K
G
P
T
L
T
V
Y
K
E
S
F
E
Site 18
Y228
K
G
P
T
L
T
V
Y
K
E
S
F
E
S
Q
Site 19
S231
T
L
T
V
Y
K
E
S
F
E
S
Q
F
L
A
Site 20
S234
V
Y
K
E
S
F
E
S
Q
F
L
A
D
T
E
Site 21
T240
E
S
Q
F
L
A
D
T
E
R
F
Y
T
R
E
Site 22
Y244
L
A
D
T
E
R
F
Y
T
R
E
S
T
E
F
Site 23
T245
A
D
T
E
R
F
Y
T
R
E
S
T
E
F
L
Site 24
S248
E
R
F
Y
T
R
E
S
T
E
F
L
Q
Q
N
Site 25
T249
R
F
Y
T
R
E
S
T
E
F
L
Q
Q
N
P
Site 26
Y278
E
Q
R
R
V
Q
V
Y
L
H
E
S
T
Q
D
Site 27
T305
K
H
L
E
I
F
H
T
E
F
Q
N
L
L
D
Site 28
Y323
N
E
D
L
G
R
M
Y
N
L
V
S
R
I
Q
Site 29
S327
G
R
M
Y
N
L
V
S
R
I
Q
D
G
L
G
Site 30
S414
A
V
T
K
M
A
Q
S
S
S
K
S
P
E
L
Site 31
S416
T
K
M
A
Q
S
S
S
K
S
P
E
L
L
A
Site 32
S418
M
A
Q
S
S
S
K
S
P
E
L
L
A
R
Y
Site 33
Y425
S
P
E
L
L
A
R
Y
C
D
S
L
L
K
K
Site 34
S428
L
L
A
R
Y
C
D
S
L
L
K
K
S
S
K
Site 35
S434
D
S
L
L
K
K
S
S
K
N
P
E
E
A
E
Site 36
T445
E
E
A
E
L
E
D
T
L
N
Q
V
M
V
V
Site 37
S479
K
R
L
V
H
Q
N
S
A
S
D
D
A
E
A
Site 38
S481
L
V
H
Q
N
S
A
S
D
D
A
E
A
S
M
Site 39
S487
A
S
D
D
A
E
A
S
M
I
S
K
L
K
Q
Site 40
Y500
K
Q
A
C
G
F
E
Y
T
S
K
L
Q
R
M
Site 41
T526
E
Q
F
K
K
H
L
T
N
S
E
P
L
D
L
Site 42
S528
F
K
K
H
L
T
N
S
E
P
L
D
L
D
F
Site 43
S541
D
F
S
I
Q
V
L
S
S
G
S
W
P
F
Q
Site 44
S542
F
S
I
Q
V
L
S
S
G
S
W
P
F
Q
Q
Site 45
S544
I
Q
V
L
S
S
G
S
W
P
F
Q
Q
S
C
Site 46
S550
G
S
W
P
F
Q
Q
S
C
T
F
A
L
P
S
Site 47
T552
W
P
F
Q
Q
S
C
T
F
A
L
P
S
E
L
Site 48
S557
S
C
T
F
A
L
P
S
E
L
E
R
S
Y
Q
Site 49
S562
L
P
S
E
L
E
R
S
Y
Q
R
F
T
A
F
Site 50
Y563
P
S
E
L
E
R
S
Y
Q
R
F
T
A
F
Y
Site 51
T567
E
R
S
Y
Q
R
F
T
A
F
Y
A
S
R
H
Site 52
Y570
Y
Q
R
F
T
A
F
Y
A
S
R
H
S
G
R
Site 53
S575
A
F
Y
A
S
R
H
S
G
R
K
L
T
W
L
Site 54
T580
R
H
S
G
R
K
L
T
W
L
Y
Q
L
S
K
Site 55
Y583
G
R
K
L
T
W
L
Y
Q
L
S
K
G
E
L
Site 56
Y620
Q
Y
N
T
E
D
A
Y
T
V
Q
Q
L
T
D
Site 57
T621
Y
N
T
E
D
A
Y
T
V
Q
Q
L
T
D
S
Site 58
Y672
P
D
T
L
I
K
L
Y
L
G
Y
K
N
K
K
Site 59
T699
Q
K
Q
E
Q
E
T
T
H
K
N
I
E
E
D
Site 60
T736
Q
L
L
G
E
V
L
T
Q
L
S
S
R
F
K
Site 61
S739
G
E
V
L
T
Q
L
S
S
R
F
K
P
R
V
Site 62
Y761
D
I
L
I
E
K
E
Y
L
E
R
V
D
G
E
Site 63
T771
R
V
D
G
E
K
D
T
Y
S
Y
L
A
_
_
Site 64
Y772
V
D
G
E
K
D
T
Y
S
Y
L
A
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation