KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
CUL3
Full Name:
Cullin-3
Alias:
KIAA0617
Type:
Cell cycle protein
Mass (Da):
88930
Number AA:
768
UniProt ID:
Q13618
International Prot ID:
IPI00014312
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0031461
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0031625
GO:0005515
GO:0019899
PhosphoSite+
KinaseNET
Biological Process:
GO:0000082
GO:0007050
GO:0008054
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
G
T
G
S
R
K
D
T
K
M
R
I
R
A
F
Site 2
T24
R
I
R
A
F
P
M
T
M
D
E
K
Y
V
N
Site 3
Y29
P
M
T
M
D
E
K
Y
V
N
S
I
W
D
L
Site 4
S50
E
I
Q
R
K
N
N
S
G
L
S
F
E
E
L
Site 5
S53
R
K
N
N
S
G
L
S
F
E
E
L
Y
R
N
Site 6
Y58
G
L
S
F
E
E
L
Y
R
N
A
Y
T
M
V
Site 7
Y62
E
E
L
Y
R
N
A
Y
T
M
V
L
H
K
H
Site 8
T63
E
L
Y
R
N
A
Y
T
M
V
L
H
K
H
G
Site 9
T75
K
H
G
E
K
L
Y
T
G
L
R
E
V
V
T
Site 10
Y130
L
M
Y
M
D
R
V
Y
V
Q
Q
N
N
V
E
Site 11
Y154
F
R
D
Q
V
V
R
Y
G
C
I
R
D
H
L
Site 12
T164
I
R
D
H
L
R
Q
T
L
L
D
M
I
A
R
Site 13
S199
I
L
G
L
E
G
R
S
V
Y
E
E
D
F
E
Site 14
Y201
G
L
E
G
R
S
V
Y
E
E
D
F
E
A
P
Site 15
S213
E
A
P
F
L
E
M
S
A
E
F
F
Q
M
E
Site 16
S221
A
E
F
F
Q
M
E
S
Q
K
F
L
A
E
N
Site 17
S231
F
L
A
E
N
S
A
S
V
Y
I
K
K
V
E
Site 18
Y233
A
E
N
S
A
S
V
Y
I
K
K
V
E
A
R
Site 19
S255
V
M
H
C
L
D
K
S
T
E
E
P
I
V
K
Site 20
T256
M
H
C
L
D
K
S
T
E
E
P
I
V
K
V
Site 21
T275
L
I
S
K
H
M
K
T
I
V
E
M
E
N
S
Site 22
Y300
T
E
D
L
G
C
M
Y
K
L
F
S
R
V
P
Site 23
S304
G
C
M
Y
K
L
F
S
R
V
P
N
G
L
K
Site 24
T312
R
V
P
N
G
L
K
T
M
C
E
C
M
S
S
Site 25
S318
K
T
M
C
E
C
M
S
S
Y
L
R
E
Q
G
Site 26
S319
T
M
C
E
C
M
S
S
Y
L
R
E
Q
G
K
Site 27
Y320
M
C
E
C
M
S
S
Y
L
R
E
Q
G
K
A
Site 28
Y341
E
G
K
N
P
V
D
Y
I
Q
G
L
L
D
L
Site 29
S350
Q
G
L
L
D
L
K
S
R
F
D
R
F
L
L
Site 30
S359
F
D
R
F
L
L
E
S
F
N
N
D
R
L
F
Site 31
T369
N
D
R
L
F
K
Q
T
I
A
G
D
F
E
Y
Site 32
Y376
T
I
A
G
D
F
E
Y
F
L
N
L
N
S
R
Site 33
S382
E
Y
F
L
N
L
N
S
R
S
P
E
Y
L
S
Site 34
S384
F
L
N
L
N
S
R
S
P
E
Y
L
S
L
F
Site 35
Y387
L
N
S
R
S
P
E
Y
L
S
L
F
I
D
D
Site 36
S389
S
R
S
P
E
Y
L
S
L
F
I
D
D
K
L
Site 37
Y431
E
K
D
V
F
E
R
Y
Y
K
Q
H
L
A
R
Site 38
Y432
K
D
V
F
E
R
Y
Y
K
Q
H
L
A
R
R
Site 39
T442
H
L
A
R
R
L
L
T
N
K
S
V
S
D
D
Site 40
S445
R
R
L
L
T
N
K
S
V
S
D
D
S
E
K
Site 41
S447
L
L
T
N
K
S
V
S
D
D
S
E
K
N
M
Site 42
S450
N
K
S
V
S
D
D
S
E
K
N
M
I
S
K
Site 43
S456
D
S
E
K
N
M
I
S
K
L
K
T
E
C
G
Site 44
S478
E
G
M
F
R
D
M
S
I
S
N
T
T
M
D
Site 45
T482
R
D
M
S
I
S
N
T
T
M
D
E
F
R
Q
Site 46
T483
D
M
S
I
S
N
T
T
M
D
E
F
R
Q
H
Site 47
T509
D
L
T
V
R
V
L
T
T
G
Y
W
P
T
Q
Site 48
Y512
V
R
V
L
T
T
G
Y
W
P
T
Q
S
A
T
Site 49
T515
L
T
T
G
Y
W
P
T
Q
S
A
T
P
K
C
Site 50
T519
Y
W
P
T
Q
S
A
T
P
K
C
N
I
P
P
Site 51
Y539
F
E
I
F
R
R
F
Y
L
A
K
H
S
G
R
Site 52
S544
R
F
Y
L
A
K
H
S
G
R
Q
L
T
L
Q
Site 53
T549
K
H
S
G
R
Q
L
T
L
Q
H
H
M
G
S
Site 54
T562
G
S
A
D
L
N
A
T
F
Y
G
P
V
K
K
Site 55
Y564
A
D
L
N
A
T
F
Y
G
P
V
K
K
E
D
Site 56
S573
P
V
K
K
E
D
G
S
E
V
G
V
G
G
A
Site 57
S585
G
G
A
Q
V
T
G
S
N
T
R
K
H
I
L
Site 58
Y611
L
F
N
N
R
E
K
Y
T
F
E
E
I
Q
Q
Site 59
T640
S
L
A
C
G
K
P
T
Q
R
V
L
T
K
E
Site 60
T645
K
P
T
Q
R
V
L
T
K
E
P
K
S
K
E
Site 61
S650
V
L
T
K
E
P
K
S
K
E
I
E
N
G
H
Site 62
T660
I
E
N
G
H
I
F
T
V
N
D
Q
F
T
S
Site 63
T676
L
H
R
V
K
I
Q
T
V
A
A
K
Q
G
E
Site 64
T691
S
D
P
E
R
K
E
T
R
Q
K
V
D
D
D
Site 65
S737
L
K
A
R
F
L
P
S
P
V
V
I
K
K
R
Site 66
Y753
E
G
L
I
E
R
E
Y
L
A
R
T
P
E
D
Site 67
T757
E
R
E
Y
L
A
R
T
P
E
D
R
K
V
Y
Site 68
Y764
T
P
E
D
R
K
V
Y
T
Y
V
A
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation