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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CUL4A
Full Name:
Cullin-4A
Alias:
Type:
Cullin-RING ubiquitin ligase complex protein
Mass (Da):
87680
Number AA:
759
UniProt ID:
Q13619
International Prot ID:
IPI00419273
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031461
GO:0031461
GO:0032991
Uniprot
OncoNet
Molecular Function:
GO:0031625
GO:0005515
GO:0019899
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0000082
GO:0007050
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
D
E
A
P
R
K
G
S
F
S
A
L
V
G
R
Site 2
S12
A
P
R
K
G
S
F
S
A
L
V
G
R
T
N
Site 3
T22
V
G
R
T
N
G
L
T
K
P
A
A
L
A
A
Site 4
Y58
R
P
R
L
P
D
N
Y
T
Q
D
T
W
R
K
Site 5
T59
P
R
L
P
D
N
Y
T
Q
D
T
W
R
K
L
Site 6
T62
P
D
N
Y
T
Q
D
T
W
R
K
L
H
E
A
Site 7
S76
A
V
R
A
V
Q
S
S
T
S
I
R
Y
N
L
Site 8
S78
R
A
V
Q
S
S
T
S
I
R
Y
N
L
E
E
Site 9
Y87
R
Y
N
L
E
E
L
Y
Q
A
V
E
N
L
C
Site 10
S95
Q
A
V
E
N
L
C
S
H
K
V
S
P
M
L
Site 11
S99
N
L
C
S
H
K
V
S
P
M
L
Y
K
Q
L
Site 12
Y103
H
K
V
S
P
M
L
Y
K
Q
L
R
Q
A
C
Site 13
S165
R
T
Y
V
L
Q
N
S
T
L
P
S
I
W
D
Site 14
S169
L
Q
N
S
T
L
P
S
I
W
D
M
G
L
E
Site 15
S184
L
F
R
T
H
I
I
S
D
K
M
V
Q
S
K
Site 16
S205
L
L
I
E
R
E
R
S
G
E
A
V
D
R
S
Site 17
S212
S
G
E
A
V
D
R
S
L
L
R
S
L
L
G
Site 18
S222
R
S
L
L
G
M
L
S
D
L
Q
V
Y
K
D
Site 19
Y227
M
L
S
D
L
Q
V
Y
K
D
S
F
E
L
K
Site 20
S230
D
L
Q
V
Y
K
D
S
F
E
L
K
F
L
E
Site 21
Y243
L
E
E
T
N
C
L
Y
A
A
E
G
Q
R
L
Site 22
Y259
Q
E
R
E
V
P
E
Y
L
N
H
V
S
K
R
Site 23
S264
P
E
Y
L
N
H
V
S
K
R
L
E
E
E
G
Site 24
T276
E
E
G
D
R
V
I
T
Y
L
D
H
S
T
Q
Site 25
Y277
E
G
D
R
V
I
T
Y
L
D
H
S
T
Q
K
Site 26
Y323
V
P
D
L
A
Q
M
Y
Q
L
F
S
R
V
R
Site 27
S327
A
Q
M
Y
Q
L
F
S
R
V
R
G
G
Q
Q
Site 28
Y343
L
L
Q
H
W
S
E
Y
I
K
T
F
G
T
A
Site 29
T396
L
M
K
E
S
F
E
T
F
I
N
K
R
P
N
Site 30
S415
L
I
A
K
H
V
D
S
K
L
R
A
G
N
K
Site 31
T432
T
D
E
E
L
E
R
T
L
D
K
I
M
I
L
Site 32
S466
K
R
L
L
V
G
K
S
A
S
V
D
A
E
K
Site 33
S474
A
S
V
D
A
E
K
S
M
L
S
K
L
K
H
Site 34
S477
D
A
E
K
S
M
L
S
K
L
K
H
E
C
G
Site 35
S516
K
Q
H
M
Q
N
Q
S
D
S
G
P
I
D
L
Site 36
S518
H
M
Q
N
Q
S
D
S
G
P
I
D
L
T
V
Site 37
Y532
V
N
I
L
T
M
G
Y
W
P
T
Y
T
P
M
Site 38
T544
T
P
M
E
V
H
L
T
P
E
M
I
K
L
Q
Site 39
Y558
Q
E
V
F
K
A
F
Y
L
G
K
H
S
G
R
Site 40
T572
R
K
L
Q
W
Q
T
T
L
G
H
A
V
L
K
Site 41
S609
F
N
E
G
D
G
F
S
F
E
E
I
K
M
A
Site 42
S622
M
A
T
G
I
E
D
S
E
L
R
R
T
L
Q
Site 43
T627
E
D
S
E
L
R
R
T
L
Q
S
L
A
C
G
Site 44
S630
E
L
R
R
T
L
Q
S
L
A
C
G
K
A
R
Site 45
S642
K
A
R
V
L
I
K
S
P
K
G
K
E
V
E
Site 46
S683
E
T
V
E
E
Q
V
S
T
T
E
R
V
F
Q
Site 47
T684
T
V
E
E
Q
V
S
T
T
E
R
V
F
Q
D
Site 48
T685
V
E
E
Q
V
S
T
T
E
R
V
F
Q
D
R
Site 49
Y694
R
V
F
Q
D
R
Q
Y
Q
I
D
A
A
I
V
Site 50
T709
R
I
M
K
M
R
K
T
L
G
H
N
L
L
V
Site 51
S738
D
L
K
K
R
I
E
S
L
I
D
R
D
Y
M
Site 52
Y744
E
S
L
I
D
R
D
Y
M
E
R
D
K
D
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation