KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PTCH1
Full Name:
Protein patched homolog 1
Alias:
BCNS; Homolog of Drosophila Patched gene; HPE7; NBCCS; patched 1; PTC; PTC1; PTCH
Type:
Membrane protein, integral; Cell cycle regulation
Mass (Da):
160540
Number AA:
UniProt ID:
Q13635
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0008158
PhosphoSite+
KinaseNET
Biological Process:
GO:0030326
GO:0040015
GO:0016485
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
Q
D
R
G
G
G
G
S
G
C
I
G
A
P
G
Site 2
T36
G
G
G
R
R
R
R
T
G
G
L
R
R
A
A
Site 3
Y49
A
A
A
P
D
R
D
Y
L
H
R
P
S
Y
C
Site 4
S54
R
D
Y
L
H
R
P
S
Y
C
D
A
A
F
A
Site 5
Y55
D
Y
L
H
R
P
S
Y
C
D
A
A
F
A
L
Site 6
T71
Q
I
S
K
G
K
A
T
G
R
K
A
P
L
W
Site 7
S137
V
E
V
G
G
R
V
S
R
E
L
N
Y
T
R
Site 8
Y142
R
V
S
R
E
L
N
Y
T
R
Q
K
I
G
E
Site 9
T143
V
S
R
E
L
N
Y
T
R
Q
K
I
G
E
E
Site 10
T161
N
P
Q
L
M
I
Q
T
P
K
E
E
G
A
N
Site 11
Y191
Q
A
S
R
V
H
V
Y
M
Y
N
R
Q
W
K
Site 12
Y193
S
R
V
H
V
Y
M
Y
N
R
Q
W
K
L
E
Site 13
Y204
W
K
L
E
H
L
C
Y
K
S
G
E
L
I
T
Site 14
S206
L
E
H
L
C
Y
K
S
G
E
L
I
T
E
T
Site 15
Y215
E
L
I
T
E
T
G
Y
M
D
Q
I
I
E
Y
Site 16
Y247
K
L
Q
S
G
T
A
Y
L
L
G
K
P
P
L
Site 17
T257
G
K
P
P
L
R
W
T
N
F
D
P
L
E
F
Site 18
Y273
E
E
L
K
K
I
N
Y
Q
V
D
S
W
E
E
Site 19
Y291
K
A
E
V
G
H
G
Y
M
D
R
P
C
L
N
Site 20
T307
A
D
P
D
C
P
A
T
A
P
N
K
N
S
T
Site 21
Y334
C
H
G
L
S
R
K
Y
M
H
W
Q
E
E
L
Site 22
T346
E
E
L
I
V
G
G
T
V
K
N
S
T
G
K
Site 23
Y373
L
M
T
P
K
Q
M
Y
E
H
F
K
G
Y
E
Site 24
Y379
M
Y
E
H
F
K
G
Y
E
Y
V
S
H
I
N
Site 25
Y403
L
E
A
W
Q
R
T
Y
V
E
V
V
H
Q
S
Site 26
S421
N
S
T
Q
K
V
L
S
F
T
T
T
T
L
D
Site 27
S435
D
D
I
L
K
S
F
S
D
V
S
V
I
R
V
Site 28
S463
T
M
L
R
W
D
C
S
K
S
Q
G
A
V
G
Site 29
S465
L
R
W
D
C
S
K
S
Q
G
A
V
G
L
A
Site 30
T537
R
I
P
F
E
D
R
T
G
E
C
L
K
R
T
Site 31
Y601
A
I
L
S
M
D
L
Y
R
R
E
D
R
R
L
Site 32
Y630
I
Q
V
E
P
Q
A
Y
T
D
T
H
D
N
T
Site 33
T633
E
P
Q
A
Y
T
D
T
H
D
N
T
R
Y
S
Site 34
T637
Y
T
D
T
H
D
N
T
R
Y
S
P
P
P
P
Site 35
Y639
D
T
H
D
N
T
R
Y
S
P
P
P
P
Y
S
Site 36
S640
T
H
D
N
T
R
Y
S
P
P
P
P
Y
S
S
Site 37
Y645
R
Y
S
P
P
P
P
Y
S
S
H
S
F
A
H
Site 38
S646
Y
S
P
P
P
P
Y
S
S
H
S
F
A
H
E
Site 39
S647
S
P
P
P
P
Y
S
S
H
S
F
A
H
E
T
Site 40
S649
P
P
P
Y
S
S
H
S
F
A
H
E
T
Q
I
Site 41
T657
F
A
H
E
T
Q
I
T
M
Q
S
T
V
Q
L
Site 42
T661
T
Q
I
T
M
Q
S
T
V
Q
L
R
T
E
Y
Site 43
Y668
T
V
Q
L
R
T
E
Y
D
P
H
T
H
V
Y
Site 44
T672
R
T
E
Y
D
P
H
T
H
V
Y
Y
T
T
A
Site 45
Y676
D
P
H
T
H
V
Y
Y
T
T
A
E
P
R
S
Site 46
T678
H
T
H
V
Y
Y
T
T
A
E
P
R
S
E
I
Site 47
S683
Y
T
T
A
E
P
R
S
E
I
S
V
Q
P
V
Site 48
S686
A
E
P
R
S
E
I
S
V
Q
P
V
T
V
T
Site 49
T691
E
I
S
V
Q
P
V
T
V
T
Q
D
T
L
S
Site 50
T693
S
V
Q
P
V
T
V
T
Q
D
T
L
S
C
Q
Site 51
T696
P
V
T
V
T
Q
D
T
L
S
C
Q
S
P
E
Site 52
S698
T
V
T
Q
D
T
L
S
C
Q
S
P
E
S
T
Site 53
S701
Q
D
T
L
S
C
Q
S
P
E
S
T
S
S
T
Site 54
S704
L
S
C
Q
S
P
E
S
T
S
S
T
R
D
L
Site 55
T705
S
C
Q
S
P
E
S
T
S
S
T
R
D
L
L
Site 56
S706
C
Q
S
P
E
S
T
S
S
T
R
D
L
L
S
Site 57
S707
Q
S
P
E
S
T
S
S
T
R
D
L
L
S
Q
Site 58
T708
S
P
E
S
T
S
S
T
R
D
L
L
S
Q
F
Site 59
S713
S
S
T
R
D
L
L
S
Q
F
S
D
S
S
L
Site 60
S716
R
D
L
L
S
Q
F
S
D
S
S
L
H
C
L
Site 61
S718
L
L
S
Q
F
S
D
S
S
L
H
C
L
E
P
Site 62
S719
L
S
Q
F
S
D
S
S
L
H
C
L
E
P
P
Site 63
T731
E
P
P
C
T
K
W
T
L
S
S
F
A
E
K
Site 64
Y740
S
S
F
A
E
K
H
Y
A
P
F
L
L
K
P
Site 65
T778
V
R
D
G
L
D
L
T
D
I
V
P
R
E
T
Site 66
T785
T
D
I
V
P
R
E
T
R
E
Y
D
F
I
A
Site 67
Y788
V
P
R
E
T
R
E
Y
D
F
I
A
A
Q
F
Site 68
Y812
I
V
T
Q
K
A
D
Y
P
N
I
Q
H
L
L
Site 69
Y820
P
N
I
Q
H
L
L
Y
D
L
H
R
S
F
S
Site 70
S825
L
L
Y
D
L
H
R
S
F
S
N
V
K
Y
V
Site 71
S827
Y
D
L
H
R
S
F
S
N
V
K
Y
V
M
L
Site 72
Y831
R
S
F
S
N
V
K
Y
V
M
L
E
E
N
K
Site 73
S861
G
L
Q
D
A
F
D
S
D
W
E
T
G
K
I
Site 74
Y873
G
K
I
M
P
N
N
Y
K
N
G
S
D
D
G
Site 75
S877
P
N
N
Y
K
N
G
S
D
D
G
V
L
A
Y
Site 76
Y884
S
D
D
G
V
L
A
Y
K
L
L
V
Q
T
G
Site 77
S892
K
L
L
V
Q
T
G
S
R
D
K
P
I
D
I
Site 78
S900
R
D
K
P
I
D
I
S
Q
L
T
K
Q
R
L
Site 79
Y934
V
S
N
D
P
V
A
Y
A
A
S
Q
A
N
I
Site 80
S937
D
P
V
A
Y
A
A
S
Q
A
N
I
R
P
H
Site 81
Y955
W
V
H
D
K
A
D
Y
M
P
E
T
R
L
R
Site 82
T959
K
A
D
Y
M
P
E
T
R
L
R
I
P
A
A
Site 83
Y977
E
Y
A
Q
F
P
F
Y
L
N
G
L
R
D
T
Site 84
T984
Y
L
N
G
L
R
D
T
S
D
F
V
E
A
I
Site 85
S985
L
N
G
L
R
D
T
S
D
F
V
E
A
I
E
Site 86
T996
E
A
I
E
K
V
R
T
I
C
S
N
Y
T
S
Site 87
S999
E
K
V
R
T
I
C
S
N
Y
T
S
L
G
L
Site 88
T1002
R
T
I
C
S
N
Y
T
S
L
G
L
S
S
Y
Site 89
S1003
T
I
C
S
N
Y
T
S
L
G
L
S
S
Y
P
Site 90
S1007
N
Y
T
S
L
G
L
S
S
Y
P
N
G
Y
P
Site 91
S1008
Y
T
S
L
G
L
S
S
Y
P
N
G
Y
P
F
Site 92
Y1009
T
S
L
G
L
S
S
Y
P
N
G
Y
P
F
L
Site 93
Y1013
L
S
S
Y
P
N
G
Y
P
F
L
F
W
E
Q
Site 94
S1185
F
G
P
Y
P
E
V
S
P
A
N
G
L
N
R
Site 95
T1195
N
G
L
N
R
L
P
T
P
S
P
E
P
P
P
Site 96
S1197
L
N
R
L
P
T
P
S
P
E
P
P
P
S
V
Site 97
S1203
P
S
P
E
P
P
P
S
V
V
R
F
A
M
P
Site 98
T1214
F
A
M
P
P
G
H
T
H
S
G
S
D
S
S
Site 99
S1216
M
P
P
G
H
T
H
S
G
S
D
S
S
D
S
Site 100
S1218
P
G
H
T
H
S
G
S
D
S
S
D
S
E
Y
Site 101
S1220
H
T
H
S
G
S
D
S
S
D
S
E
Y
S
S
Site 102
S1221
T
H
S
G
S
D
S
S
D
S
E
Y
S
S
Q
Site 103
S1223
S
G
S
D
S
S
D
S
E
Y
S
S
Q
T
T
Site 104
Y1225
S
D
S
S
D
S
E
Y
S
S
Q
T
T
V
S
Site 105
S1227
S
S
D
S
E
Y
S
S
Q
T
T
V
S
G
L
Site 106
T1230
S
E
Y
S
S
Q
T
T
V
S
G
L
S
E
E
Site 107
Y1241
L
S
E
E
L
R
H
Y
E
A
Q
Q
G
A
G
Site 108
S1267
E
N
P
V
F
A
H
S
T
V
V
H
P
E
S
Site 109
T1268
N
P
V
F
A
H
S
T
V
V
H
P
E
S
R
Site 110
S1274
S
T
V
V
H
P
E
S
R
H
H
P
P
S
N
Site 111
S1280
E
S
R
H
H
P
P
S
N
P
R
Q
Q
P
H
Site 112
S1290
R
Q
Q
P
H
L
D
S
G
S
L
P
P
G
R
Site 113
S1292
Q
P
H
L
D
S
G
S
L
P
P
G
R
Q
G
Site 114
Y1316
E
G
L
W
P
P
P
Y
R
P
R
R
D
A
F
Site 115
S1326
R
R
D
A
F
E
I
S
T
E
G
H
S
G
P
Site 116
T1327
R
D
A
F
E
I
S
T
E
G
H
S
G
P
S
Site 117
S1334
T
E
G
H
S
G
P
S
N
R
A
R
W
G
P
Site 118
S1346
W
G
P
R
G
A
R
S
H
N
P
R
N
P
A
Site 119
S1354
H
N
P
R
N
P
A
S
T
A
M
G
S
S
V
Site 120
T1355
N
P
R
N
P
A
S
T
A
M
G
S
S
V
P
Site 121
S1359
P
A
S
T
A
M
G
S
S
V
P
G
Y
C
Q
Site 122
Y1401
R
G
G
L
C
P
G
Y
P
E
T
D
H
G
L
Site 123
T1404
L
C
P
G
Y
P
E
T
D
H
G
L
F
E
D
Site 124
S1425
V
R
C
E
R
R
D
S
K
V
E
V
I
E
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation