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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NCOA4
Full Name:
Nuclear receptor coactivator 4
Alias:
70 kDa androgen receptor coactivator; ARA70; DKFZp762E1112; ELE1; Nuclear receptor coactivator 4 - PTC3 (ELE1); PTC3; RET-activating gene ELE1; RFG
Type:
Nuclear receptor co-regulator
Mass (Da):
69726
Number AA:
614
UniProt ID:
Q13772
International Prot ID:
IPI00015145
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003712
GO:0003713
GO:0005102
PhosphoSite+
KinaseNET
Biological Process:
GO:0003006
GO:0006139
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
N
T
F
Q
D
Q
S
G
S
S
S
N
R
E
Site 2
S10
T
F
Q
D
Q
S
G
S
S
S
N
R
E
P
L
Site 3
S12
Q
D
Q
S
G
S
S
S
N
R
E
P
L
L
R
Site 4
S21
R
E
P
L
L
R
C
S
D
A
R
R
D
L
E
Site 5
S57
A
Q
I
H
S
C
I
S
R
H
L
E
C
L
R
Site 6
S65
R
H
L
E
C
L
R
S
R
E
V
W
L
Y
E
Site 7
Y71
R
S
R
E
V
W
L
Y
E
Q
V
D
L
I
Y
Site 8
Y78
Y
E
Q
V
D
L
I
Y
Q
L
K
E
E
T
L
Site 9
S119
K
D
L
A
N
Q
V
S
V
C
L
E
R
L
G
Site 10
S127
V
C
L
E
R
L
G
S
L
T
L
K
P
E
D
Site 11
T129
L
E
R
L
G
S
L
T
L
K
P
E
D
S
T
Site 12
T136
T
L
K
P
E
D
S
T
V
L
L
F
E
A
D
Site 13
S171
E
H
L
M
A
H
A
S
S
A
N
I
G
P
F
Site 14
S192
I
S
M
P
E
Q
K
S
A
S
G
I
V
A
V
Site 15
S208
F
S
E
W
L
L
G
S
K
P
A
S
G
Y
Q
Site 16
S212
L
L
G
S
K
P
A
S
G
Y
Q
A
P
Y
I
Site 17
Y214
G
S
K
P
A
S
G
Y
Q
A
P
Y
I
P
S
Site 18
Y218
A
S
G
Y
Q
A
P
Y
I
P
S
T
D
P
Q
Site 19
T222
Q
A
P
Y
I
P
S
T
D
P
Q
D
W
L
T
Site 20
T229
T
D
P
Q
D
W
L
T
Q
K
Q
T
L
E
N
Site 21
T233
D
W
L
T
Q
K
Q
T
L
E
N
S
Q
T
S
Site 22
S237
Q
K
Q
T
L
E
N
S
Q
T
S
S
R
A
C
Site 23
T239
Q
T
L
E
N
S
Q
T
S
S
R
A
C
N
F
Site 24
S241
L
E
N
S
Q
T
S
S
R
A
C
N
F
F
N
Site 25
S264
L
E
N
W
L
L
K
S
E
K
S
S
Y
Q
K
Site 26
S267
W
L
L
K
S
E
K
S
S
Y
Q
K
C
N
S
Site 27
S268
L
L
K
S
E
K
S
S
Y
Q
K
C
N
S
H
Site 28
Y269
L
K
S
E
K
S
S
Y
Q
K
C
N
S
H
S
Site 29
S274
S
S
Y
Q
K
C
N
S
H
S
T
T
S
S
F
Site 30
S276
Y
Q
K
C
N
S
H
S
T
T
S
S
F
S
I
Site 31
T277
Q
K
C
N
S
H
S
T
T
S
S
F
S
I
E
Site 32
T278
K
C
N
S
H
S
T
T
S
S
F
S
I
E
M
Site 33
S280
N
S
H
S
T
T
S
S
F
S
I
E
M
E
K
Site 34
S302
D
Q
D
E
M
D
L
S
D
W
L
V
T
P
Q
Site 35
T307
D
L
S
D
W
L
V
T
P
Q
E
S
H
K
L
Site 36
T324
P
E
N
G
S
R
E
T
S
E
K
F
K
L
L
Site 37
S325
E
N
G
S
R
E
T
S
E
K
F
K
L
L
F
Site 38
S334
K
F
K
L
L
F
Q
S
Y
N
V
N
D
W
L
Site 39
T348
L
V
K
T
D
S
C
T
N
C
Q
G
N
Q
P
Site 40
S380
L
E
A
K
K
P
L
S
T
P
S
M
V
T
E
Site 41
T381
E
A
K
K
P
L
S
T
P
S
M
V
T
E
D
Site 42
S383
K
K
P
L
S
T
P
S
M
V
T
E
D
W
L
Site 43
S456
E
P
E
K
H
K
D
S
L
N
M
W
L
C
P
Site 44
T478
T
K
A
P
K
A
M
T
P
S
R
I
A
D
S
Site 45
S480
A
P
K
A
M
T
P
S
R
I
A
D
S
F
Q
Site 46
S485
T
P
S
R
I
A
D
S
F
Q
V
I
K
N
S
Site 47
S495
V
I
K
N
S
P
L
S
E
W
L
I
R
P
P
Site 48
Y503
E
W
L
I
R
P
P
Y
K
E
G
S
P
K
E
Site 49
S507
R
P
P
Y
K
E
G
S
P
K
E
V
P
G
T
Site 50
T514
S
P
K
E
V
P
G
T
E
D
R
A
G
K
Q
Site 51
S525
A
G
K
Q
K
F
K
S
P
M
N
T
S
W
C
Site 52
S550
G
K
K
M
G
N
L
S
Q
L
S
S
G
E
D
Site 53
S554
G
N
L
S
Q
L
S
S
G
E
D
K
W
L
L
Site 54
S572
A
Q
E
V
L
L
N
S
P
L
Q
E
E
H
N
Site 55
Y585
H
N
F
P
P
D
H
Y
G
L
P
A
V
C
D
Site 56
Y608
V
D
K
E
K
W
L
Y
R
T
P
L
Q
M
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation