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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GNL2
Full Name:
Nucleolar GTP-binding protein 2
Alias:
Autoantigen NGP-1; Guanine nucleotide binding protein-like 2 (nucleolar); HUMAUANTIG; NGP1; Ngp-1; NOG2
Type:
GTPase activating protein, misc.
Mass (Da):
83655
Number AA:
731
UniProt ID:
Q13823
International Prot ID:
IPI00015808
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0003924
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0042254
GO:0003924
GO:0005515
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T11
P
K
Y
K
G
R
S
T
I
N
P
S
K
A
S
Site 2
S15
G
R
S
T
I
N
P
S
K
A
S
T
N
P
D
Site 3
T19
I
N
P
S
K
A
S
T
N
P
D
R
V
Q
G
Site 4
T37
Q
N
M
R
D
R
A
T
I
R
R
L
N
M
Y
Site 5
Y44
T
I
R
R
L
N
M
Y
R
Q
K
E
R
R
N
Site 6
S52
R
Q
K
E
R
R
N
S
R
G
K
I
I
K
P
Site 7
Y62
K
I
I
K
P
L
Q
Y
Q
S
T
V
A
S
G
Site 8
S64
I
K
P
L
Q
Y
Q
S
T
V
A
S
G
T
V
Site 9
T65
K
P
L
Q
Y
Q
S
T
V
A
S
G
T
V
A
Site 10
S68
Q
Y
Q
S
T
V
A
S
G
T
V
A
R
V
E
Site 11
T70
Q
S
T
V
A
S
G
T
V
A
R
V
E
P
N
Site 12
S90
N
T
R
V
I
K
Q
S
S
L
Q
K
F
Q
E
Site 13
S91
T
R
V
I
K
Q
S
S
L
Q
K
F
Q
E
E
Site 14
T101
K
F
Q
E
E
M
D
T
V
M
K
D
P
Y
K
Site 15
Y107
D
T
V
M
K
D
P
Y
K
V
V
M
K
Q
S
Site 16
S119
K
Q
S
K
L
P
M
S
L
L
H
D
R
I
R
Site 17
T137
L
K
V
H
I
L
D
T
E
S
F
E
T
T
F
Site 18
S139
V
H
I
L
D
T
E
S
F
E
T
T
F
G
P
Site 19
T142
L
D
T
E
S
F
E
T
T
F
G
P
K
S
Q
Site 20
T143
D
T
E
S
F
E
T
T
F
G
P
K
S
Q
R
Site 21
S148
E
T
T
F
G
P
K
S
Q
R
K
R
P
N
L
Site 22
S158
K
R
P
N
L
F
A
S
D
M
Q
S
L
I
E
Site 23
Y174
A
E
M
S
T
E
S
Y
D
Q
G
K
D
R
D
Site 24
T184
G
K
D
R
D
L
V
T
E
D
T
G
V
R
N
Site 25
T187
R
D
L
V
T
E
D
T
G
V
R
N
E
A
Q
Site 26
Y198
N
E
A
Q
E
E
I
Y
K
K
G
Q
S
K
R
Site 27
S203
E
I
Y
K
K
G
Q
S
K
R
I
W
G
E
L
Site 28
Y211
K
R
I
W
G
E
L
Y
K
V
I
D
S
S
D
Site 29
T232
D
A
R
D
P
M
G
T
R
S
P
H
I
E
T
Site 30
S234
R
D
P
M
G
T
R
S
P
H
I
E
T
Y
L
Site 31
Y240
R
S
P
H
I
E
T
Y
L
K
K
E
K
P
W
Site 32
S273
K
R
W
V
A
V
L
S
Q
D
Y
P
T
L
A
Site 33
S284
P
T
L
A
F
H
A
S
L
T
N
P
F
G
K
Site 34
S312
H
T
D
K
K
Q
I
S
V
G
F
I
G
Y
P
Site 35
S324
G
Y
P
N
V
G
K
S
S
V
I
N
T
L
R
Site 36
T329
G
K
S
S
V
I
N
T
L
R
S
K
K
V
C
Site 37
Y367
I
D
C
P
G
V
V
Y
P
S
E
D
S
E
T
Site 38
T374
Y
P
S
E
D
S
E
T
D
I
V
L
K
G
V
Site 39
S389
V
Q
V
E
K
I
K
S
P
E
D
H
I
G
A
Site 40
Y405
L
E
R
A
K
P
E
Y
I
S
K
T
Y
K
I
Site 41
S407
R
A
K
P
E
Y
I
S
K
T
Y
K
I
D
S
Site 42
T409
K
P
E
Y
I
S
K
T
Y
K
I
D
S
W
E
Site 43
S414
S
K
T
Y
K
I
D
S
W
E
N
A
E
D
F
Site 44
T442
G
G
E
P
D
L
Q
T
V
G
K
M
V
L
N
Site 45
T497
P
G
E
E
V
T
E
T
A
G
E
G
S
E
S
Site 46
S504
T
A
G
E
G
S
E
S
I
I
K
E
E
T
E
Site 47
T510
E
S
I
I
K
E
E
T
E
E
N
S
H
C
D
Site 48
S553
D
L
V
P
V
E
V
S
D
L
E
E
E
L
E
Site 49
S561
D
L
E
E
E
L
E
S
F
S
D
E
E
E
E
Site 50
S563
E
E
E
L
E
S
F
S
D
E
E
E
E
E
Q
Site 51
S580
Q
R
D
D
A
E
E
S
S
S
E
P
E
E
E
Site 52
S581
R
D
D
A
E
E
S
S
S
E
P
E
E
E
N
Site 53
S582
D
D
A
E
E
S
S
S
E
P
E
E
E
N
V
Site 54
Y607
L
D
E
K
I
A
K
Y
Q
K
F
L
D
K
A
Site 55
S620
K
A
K
A
K
K
F
S
A
V
R
I
S
K
G
Site 56
S625
K
F
S
A
V
R
I
S
K
G
L
S
E
K
I
Site 57
S629
V
R
I
S
K
G
L
S
E
K
I
F
A
K
P
Site 58
T642
K
P
E
E
Q
R
K
T
L
E
E
D
V
D
D
Site 59
S653
D
V
D
D
R
A
P
S
K
K
G
K
K
R
K
Site 60
S670
R
E
E
E
Q
E
H
S
N
K
A
P
R
A
L
Site 61
T678
N
K
A
P
R
A
L
T
S
K
E
R
R
R
A
Site 62
S679
K
A
P
R
A
L
T
S
K
E
R
R
R
A
V
Site 63
Y698
P
K
K
V
G
V
R
Y
Y
E
T
H
N
V
K
Site 64
Y699
K
K
V
G
V
R
Y
Y
E
T
H
N
V
K
N
Site 65
T714
R
N
R
N
K
K
K
T
N
D
S
E
G
Q
K
Site 66
S717
N
K
K
K
T
N
D
S
E
G
Q
K
H
K
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation