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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TNFAIP1
Full Name:
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
Alias:
B12; B61; EDP1; MGC2317; TNAP1; tumor necrosis factor, alpha-induced protein 1 (endothelial); Tumor necrosis factor, alpha-induced protein 1, endothelial
Type:
Mass (Da):
36204
Number AA:
316
UniProt ID:
Q13829
International Prot ID:
IPI00015819
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008076
GO:0016020
GO:0032991
Uniprot
OncoNet
Molecular Function:
GO:0005249
GO:0005216
GO:0005244
PhosphoSite+
KinaseNET
Biological Process:
GO:0006260
GO:0009790
GO:0006955
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T5
_
_
_
M
S
G
D
T
C
L
C
P
A
S
G
Site 2
S11
D
T
C
L
C
P
A
S
G
A
K
P
K
L
S
Site 3
S18
S
G
A
K
P
K
L
S
G
F
K
G
G
G
L
Site 4
Y29
G
G
G
L
G
N
K
Y
V
Q
L
N
V
G
G
Site 5
T42
G
G
S
L
Y
Y
T
T
V
R
A
L
T
R
H
Site 6
T47
Y
T
T
V
R
A
L
T
R
H
D
T
M
L
K
Site 7
T51
R
A
L
T
R
H
D
T
M
L
K
A
M
F
S
Site 8
T65
S
G
R
M
E
V
L
T
D
K
E
G
W
I
L
Site 9
T82
R
C
G
K
H
F
G
T
I
L
N
Y
L
R
D
Site 10
Y86
H
F
G
T
I
L
N
Y
L
R
D
D
T
I
T
Site 11
T91
L
N
Y
L
R
D
D
T
I
T
L
P
Q
N
R
Site 12
T93
Y
L
R
D
D
T
I
T
L
P
Q
N
R
Q
E
Site 13
S130
A
L
Q
D
K
K
D
S
Y
Q
P
V
C
N
I
Site 14
Y131
L
Q
D
K
K
D
S
Y
Q
P
V
C
N
I
P
Site 15
S142
C
N
I
P
I
I
T
S
L
K
E
E
E
R
L
Site 16
S153
E
E
R
L
I
E
S
S
T
K
P
V
V
K
L
Site 17
Y162
K
P
V
V
K
L
L
Y
N
R
S
N
N
K
Y
Site 18
S165
V
K
L
L
Y
N
R
S
N
N
K
Y
S
Y
T
Site 19
Y169
Y
N
R
S
N
N
K
Y
S
Y
T
S
N
S
D
Site 20
S170
N
R
S
N
N
K
Y
S
Y
T
S
N
S
D
D
Site 21
Y171
R
S
N
N
K
Y
S
Y
T
S
N
S
D
D
H
Site 22
T172
S
N
N
K
Y
S
Y
T
S
N
S
D
D
H
L
Site 23
S175
K
Y
S
Y
T
S
N
S
D
D
H
L
L
K
N
Site 24
S190
I
E
L
F
D
K
L
S
L
R
F
N
G
R
V
Site 25
T237
Y
A
T
E
K
K
Q
T
K
V
E
F
P
E
A
Site 26
Y247
E
F
P
E
A
R
I
Y
E
E
T
L
N
V
L
Site 27
T250
E
A
R
I
Y
E
E
T
L
N
V
L
L
Y
E
Site 28
Y256
E
T
L
N
V
L
L
Y
E
T
P
R
V
P
D
Site 29
T258
L
N
V
L
L
Y
E
T
P
R
V
P
D
N
S
Site 30
S265
T
P
R
V
P
D
N
S
L
L
E
A
T
S
R
Site 31
S271
N
S
L
L
E
A
T
S
R
S
R
S
Q
A
S
Site 32
S273
L
L
E
A
T
S
R
S
R
S
Q
A
S
P
S
Site 33
S275
E
A
T
S
R
S
R
S
Q
A
S
P
S
E
D
Site 34
S278
S
R
S
R
S
Q
A
S
P
S
E
D
E
E
T
Site 35
S280
S
R
S
Q
A
S
P
S
E
D
E
E
T
F
E
Site 36
T285
S
P
S
E
D
E
E
T
F
E
L
R
D
R
V
Site 37
S301
R
I
H
V
K
R
Y
S
T
Y
D
D
R
Q
L
Site 38
T302
I
H
V
K
R
Y
S
T
Y
D
D
R
Q
L
G
Site 39
Y303
H
V
K
R
Y
S
T
Y
D
D
R
Q
L
G
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation