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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Brk (breast tumour kinase)
Full Name:
Protein-tyrosine kinase 6
Alias:
Brk6; EC 2.7.10.2; PTK6; Tyrosine-protein kinase 6
Type:
Protein-tyrosine kinase, TK group, Src family
Mass (Da):
51834
Number AA:
451
UniProt ID:
Q13882
International Prot ID:
IPI00015927
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004715
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Protein-tyrosine kinase 6 S446+Y447 phosphosite-specific antibody AB-PK547#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK547#Protein-tyrosine kinase 6 Y342 phosphosite-specific antibody AB-PK548#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK548#Protein-tyrosine kinase 6 (S443-P450, human) pS446+pY447 phosphopeptide - Powder PE-04AHP00#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AHP00#Protein-tyrosine kinase 6 (E339-H345, human) pY342 phosphopeptide - Powder PE-04AIV99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AIV99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
Q
A
H
L
G
P
K
Y
V
G
L
W
D
F
K
Site 2
S21
V
G
L
W
D
F
K
S
R
T
D
E
E
L
S
Site 3
T23
L
W
D
F
K
S
R
T
D
E
E
L
S
F
R
Site 4
S28
S
R
T
D
E
E
L
S
F
R
A
G
D
V
F
Site 5
Y66
Q
G
Y
V
P
H
N
Y
L
A
E
R
E
T
V
Site 6
T72
N
Y
L
A
E
R
E
T
V
E
S
E
P
W
F
Site 7
S86
F
F
G
C
I
S
R
S
E
A
V
R
R
L
Q
Site 8
S107
G
A
F
L
I
R
V
S
E
K
P
S
A
D
Y
Site 9
S111
I
R
V
S
E
K
P
S
A
D
Y
V
L
S
V
Site 10
Y114
S
E
K
P
S
A
D
Y
V
L
S
V
R
D
T
Site 11
S117
P
S
A
D
Y
V
L
S
V
R
D
T
Q
A
V
Site 12
T121
Y
V
L
S
V
R
D
T
Q
A
V
R
H
Y
K
Site 13
Y127
D
T
Q
A
V
R
H
Y
K
I
W
R
R
A
G
Site 14
Y154
S
L
P
E
L
V
N
Y
H
R
A
Q
S
L
S
Site 15
S159
V
N
Y
H
R
A
Q
S
L
S
H
G
L
R
L
Site 16
S161
Y
H
R
A
Q
S
L
S
H
G
L
R
L
A
A
Site 17
T192
E
R
P
R
E
E
F
T
L
C
R
K
L
G
S
Site 18
Y201
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
Site 19
S222
Q
V
A
I
K
V
I
S
R
D
N
L
L
H
Q
Site 20
S279
L
L
E
L
L
R
D
S
D
E
K
V
L
P
V
Site 21
Y302
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
Site 22
Y308
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
Site 23
Y342
R
L
I
K
E
D
V
Y
L
S
H
D
H
N
I
Protein-tyrosine kinase 6 Y342 phosphosite-specific antibody AB-PK548#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK548#Protein-tyrosine kinase 6 (E339-H345, human) pY342 phosphopeptide - Powder PE-04AIV99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AIV99
Site 24
S344
I
K
E
D
V
Y
L
S
H
D
H
N
I
P
Y
Site 25
Y351
S
H
D
H
N
I
P
Y
K
W
T
A
P
E
A
Site 26
Y364
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
Site 27
T366
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
Site 28
S368
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
Site 29
S372
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
Site 30
Y388
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
Site 31
Y404
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
Site 32
S442
K
A
L
R
E
R
L
S
S
F
T
S
Y
E
N
Site 33
S443
A
L
R
E
R
L
S
S
F
T
S
Y
E
N
P
Site 34
T445
R
E
R
L
S
S
F
T
S
Y
E
N
P
T
_
Site 35
S446
E
R
L
S
S
F
T
S
Y
E
N
P
T
_
_
Protein-tyrosine kinase 6 S446+Y447 phosphosite-specific antibody AB-PK547#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK547#Protein-tyrosine kinase 6 (S443-P450, human) pS446+pY447 phosphopeptide - Powder PE-04AHP00#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AHP00
Site 36
Y447
R
L
S
S
F
T
S
Y
E
N
P
T
_
_
_
Protein-tyrosine kinase 6 S446+Y447 phosphosite-specific antibody AB-PK547#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK547#Protein-tyrosine kinase 6 (S443-P450, human) pS446+pY447 phosphopeptide - Powder PE-04AHP00#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AHP00
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation