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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GTF2H2
Full Name:
General transcription factor IIH subunit 2
Alias:
Basic transcription factor 2 44 kDa; BTF2; BTF2P44; BTF2-p44; General transcription factor IIH polypeptide 2; General transcription factor IIH, polypeptide 2, 44kDa; T-BTF2P44; TF2H2; TFIIH; TFIIH basal transcription factor complex p44
Type:
Transcription factor
Mass (Da):
44419
Number AA:
395
UniProt ID:
Q13888
International Prot ID:
IPI00426640
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005675
Uniprot
OncoNet
Molecular Function:
GO:0047485
GO:0003700
GO:0008135
PhosphoSite+
KinaseNET
Biological Process:
GO:0002031
GO:0006368
GO:0000718
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
D
E
E
P
E
R
T
K
R
W
E
G
G
Y
Site 2
Y15
T
K
R
W
E
G
G
Y
E
R
T
W
E
I
L
Site 3
S27
E
I
L
K
E
D
E
S
G
S
L
K
A
T
I
Site 4
S29
L
K
E
D
E
S
G
S
L
K
A
T
I
E
D
Site 5
T33
E
S
G
S
L
K
A
T
I
E
D
I
L
F
K
Site 6
T82
D
L
K
P
N
R
L
T
C
T
L
K
L
L
E
Site 7
Y95
L
E
Y
F
V
E
E
Y
F
D
Q
N
P
I
S
Site 8
S111
I
G
I
I
V
T
K
S
K
R
A
E
K
L
T
Site 9
T118
S
K
R
A
E
K
L
T
E
L
S
G
N
P
R
Site 10
S121
A
E
K
L
T
E
L
S
G
N
P
R
K
H
I
Site 11
S130
N
P
R
K
H
I
T
S
L
K
K
A
V
D
M
Site 12
T138
L
K
K
A
V
D
M
T
C
H
G
E
P
S
L
Site 13
S144
M
T
C
H
G
E
P
S
L
Y
N
S
L
S
I
Site 14
Y146
C
H
G
E
P
S
L
Y
N
S
L
S
I
A
M
Site 15
S148
G
E
P
S
L
Y
N
S
L
S
I
A
M
Q
T
Site 16
S150
P
S
L
Y
N
S
L
S
I
A
M
Q
T
L
K
Site 17
S180
S
L
T
T
C
D
P
S
N
I
Y
D
L
I
K
Site 18
Y183
T
C
D
P
S
N
I
Y
D
L
I
K
T
L
K
Site 19
T188
N
I
Y
D
L
I
K
T
L
K
A
A
K
I
R
Site 20
T218
L
A
R
E
T
G
G
T
Y
H
V
I
L
D
E
Site 21
Y228
V
I
L
D
E
S
H
Y
K
E
L
L
T
H
H
Site 22
T233
S
H
Y
K
E
L
L
T
H
H
V
S
P
P
P
Site 23
S237
E
L
L
T
H
H
V
S
P
P
P
A
S
S
S
Site 24
S242
H
V
S
P
P
P
A
S
S
S
S
E
C
S
L
Site 25
S243
V
S
P
P
P
A
S
S
S
S
E
C
S
L
I
Site 26
S244
S
P
P
P
A
S
S
S
S
E
C
S
L
I
R
Site 27
S245
P
P
P
A
S
S
S
S
E
C
S
L
I
R
M
Site 28
S248
A
S
S
S
S
E
C
S
L
I
R
M
G
F
P
Site 29
T258
R
M
G
F
P
Q
H
T
I
A
S
L
S
D
Q
Site 30
S261
F
P
Q
H
T
I
A
S
L
S
D
Q
D
A
K
Site 31
S263
Q
H
T
I
A
S
L
S
D
Q
D
A
K
P
S
Site 32
S270
S
D
Q
D
A
K
P
S
F
S
M
A
H
L
D
Site 33
T285
G
N
T
E
P
G
L
T
L
G
G
Y
F
C
P
Site 34
Y289
P
G
L
T
L
G
G
Y
F
C
P
Q
C
R
A
Site 35
Y298
C
P
Q
C
R
A
K
Y
C
E
L
P
V
E
C
Site 36
Y322
A
P
H
L
A
R
S
Y
H
H
L
F
P
L
D
Site 37
Y346
Y
N
G
E
R
F
C
Y
G
C
Q
G
E
L
K
Site 38
Y358
E
L
K
D
Q
H
V
Y
V
C
A
V
C
Q
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation