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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDE7A
Full Name:
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Alias:
HCP1; PDE7; phosphodiesterase 7A
Type:
Phosphodiesterase
Mass (Da):
55505
Number AA:
482
UniProt ID:
Q13946
International Prot ID:
IPI00217833
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000267
Uniprot
OncoNet
Molecular Function:
GO:0004115
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
P
V
P
Q
H
V
L
S
R
R
G
A
I
S
F
Site 2
S28
L
S
R
R
G
A
I
S
F
S
S
S
S
A
L
Site 3
S30
R
R
G
A
I
S
F
S
S
S
S
A
L
F
G
Site 4
S45
C
P
N
P
R
Q
L
S
Q
R
R
G
A
I
S
Site 5
S52
S
Q
R
R
G
A
I
S
Y
D
S
S
D
Q
T
Site 6
Y53
Q
R
R
G
A
I
S
Y
D
S
S
D
Q
T
A
Site 7
S55
R
G
A
I
S
Y
D
S
S
D
Q
T
A
L
Y
Site 8
S56
G
A
I
S
Y
D
S
S
D
Q
T
A
L
Y
I
Site 9
T59
S
Y
D
S
S
D
Q
T
A
L
Y
I
R
M
L
Site 10
Y62
S
S
D
Q
T
A
L
Y
I
R
M
L
G
D
V
Site 11
S73
L
G
D
V
R
V
R
S
R
A
G
F
E
S
E
Site 12
S79
R
S
R
A
G
F
E
S
E
R
R
G
S
H
P
Site 13
S84
F
E
S
E
R
R
G
S
H
P
Y
I
D
F
R
Site 14
Y87
E
R
R
G
S
H
P
Y
I
D
F
R
I
F
H
Site 15
S95
I
D
F
R
I
F
H
S
Q
S
E
I
E
V
S
Site 16
S97
F
R
I
F
H
S
Q
S
E
I
E
V
S
V
S
Site 17
S102
S
Q
S
E
I
E
V
S
V
S
A
R
N
I
R
Site 18
S104
S
E
I
E
V
S
V
S
A
R
N
I
R
R
L
Site 19
S113
R
N
I
R
R
L
L
S
F
Q
R
Y
L
R
S
Site 20
Y117
R
L
L
S
F
Q
R
Y
L
R
S
S
R
F
F
Site 21
S120
S
F
Q
R
Y
L
R
S
S
R
F
F
R
G
T
Site 22
S121
F
Q
R
Y
L
R
S
S
R
F
F
R
G
T
A
Site 23
T127
S
S
R
F
F
R
G
T
A
V
S
N
S
L
N
Site 24
S132
R
G
T
A
V
S
N
S
L
N
I
L
D
D
D
Site 25
Y140
L
N
I
L
D
D
D
Y
N
G
Q
A
K
C
M
Site 26
S169
D
R
L
T
N
G
N
S
L
V
S
L
T
F
H
Site 27
Y205
L
V
M
I
Q
E
D
Y
H
S
Q
N
P
Y
H
Site 28
Y211
D
Y
H
S
Q
N
P
Y
H
N
A
V
H
A
A
Site 29
S236
K
E
P
K
L
A
N
S
V
T
P
W
D
I
L
Site 30
T273
K
T
N
H
Y
L
A
T
L
Y
K
N
T
S
V
Site 31
Y275
N
H
Y
L
A
T
L
Y
K
N
T
S
V
L
E
Site 32
S300
L
R
E
S
G
L
F
S
H
L
P
L
E
S
R
Site 33
T312
E
S
R
Q
Q
M
E
T
Q
I
G
A
L
I
L
Site 34
S324
L
I
L
A
T
D
I
S
R
Q
N
E
Y
L
S
Site 35
Y329
D
I
S
R
Q
N
E
Y
L
S
L
F
R
S
H
Site 36
S331
S
R
Q
N
E
Y
L
S
L
F
R
S
H
L
D
Site 37
S335
E
Y
L
S
L
F
R
S
H
L
D
R
G
D
L
Site 38
T347
G
D
L
C
L
E
D
T
R
H
R
H
L
V
L
Site 39
S377
W
E
L
S
K
Q
W
S
E
K
V
T
E
E
F
Site 40
T381
K
Q
W
S
E
K
V
T
E
E
F
F
H
Q
G
Site 41
Y394
Q
G
D
I
E
K
K
Y
H
L
G
V
S
P
L
Site 42
S399
K
K
Y
H
L
G
V
S
P
L
C
D
R
H
T
Site 43
T406
S
P
L
C
D
R
H
T
E
S
I
A
N
I
Q
Site 44
T426
Y
L
V
E
P
L
F
T
E
W
A
R
F
S
N
Site 45
S432
F
T
E
W
A
R
F
S
N
T
R
L
S
Q
T
Site 46
S437
R
F
S
N
T
R
L
S
Q
T
M
L
G
H
V
Site 47
S459
K
G
L
Q
R
E
Q
S
S
S
E
D
T
D
A
Site 48
S461
L
Q
R
E
Q
S
S
S
E
D
T
D
A
A
F
Site 49
T464
E
Q
S
S
S
E
D
T
D
A
A
F
E
L
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation