PhosphoNET

           
Protein Info 
   
Short Name:  RUNX2
Full Name:  Runt-related transcription factor 2
Alias:  Acute myeloid leukemia 3 protein; AML3; CBFA1; CBF-alpha 1; CCD; CCD1; Core-binding factor, alpha 1 subunit; Oncogene AML-3; OSF2; OSF-2; Osteoblast- specific transcription factor 2; PEA2-alpha A; PEBP2A; PEBP2A1; PEBP2aA1; PEBP2-alpha A; Polyomavirus enhancer-binding protein 2 alpha A subunit; SL3/AKV core-binding factor alpha A subunit; SL3-3 enhancer factor 1 alpha A subunit
Type:  Transcription protein
Mass (Da):  56648
Number AA:  521
UniProt ID:  Q13950
International Prot ID:  IPI00216242
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:      Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0003702  GO:0005515 PhosphoSite+ KinaseNET
Biological Process:  GO:0016481  GO:0006350   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T9ASNSLFSTVTPCQQN
Site 2T11NSLFSTVTPCQQNFF
Site 3S22QNFFWDPSTSRRFSP
Site 4T23NFFWDPSTSRRFSPP
Site 5S24FFWDPSTSRRFSPPS
Site 6S28PSTSRRFSPPSSSLQ
Site 7S31SRRFSPPSSSLQPGK
Site 8S32RRFSPPSSSLQPGKM
Site 9S33RFSPPSSSLQPGKMS
Site 10S43PGKMSDVSPVVAAQQ
Site 11T101RPPHDNRTMVEIIAD
Site 12T116HPAELVRTDSPNFLC
Site 13S118AELVRTDSPNFLCSV
Site 14S124DSPNFLCSVLPSHWR
Site 15Y164MAGNDENYSAELRNA
Site 16S172SAELRNASAVMKNQV
Site 17S191DLRFVGRSGRGKSFT
Site 18S196GRSGRGKSFTLTITV
Site 19T200RGKSFTLTITVFTNP
Site 20T202KSFTLTITVFTNPPQ
Site 21T220YHRAIKVTVDGPREP
Site 22S237HRQKLDDSKPSLFSD
Site 23S240KLDDSKPSLFSDRLS
Site 24S243DSKPSLFSDRLSDLG
Site 25S247SLFSDRLSDLGRIPH
Site 26S256LGRIPHPSMRVGVPP
Site 27S269PPQNPRPSLNSAPSP
Site 28S272NPRPSLNSAPSPFNP
Site 29S275PSLNSAPSPFNPQGQ
Site 30S283PFNPQGQSQITDPRQ
Site 31S293TDPRQAQSSPPWSYD
Site 32S294DPRQAQSSPPWSYDQ
Site 33S298AQSSPPWSYDQSYPS
Site 34Y299QSSPPWSYDQSYPSY
Site 35S302PPWSYDQSYPSYLSQ
Site 36Y303PWSYDQSYPSYLSQM
Site 37S305SYDQSYPSYLSQMTS
Site 38Y306YDQSYPSYLSQMTSP
Site 39S308QSYPSYLSQMTSPSI
Site 40S312SYLSQMTSPSIHSTT
Site 41S314LSQMTSPSIHSTTPL
Site 42S317MTSPSIHSTTPLSST
Site 43T318TSPSIHSTTPLSSTR
Site 44T319SPSIHSTTPLSSTRG
Site 45S322IHSTTPLSSTRGTGL
Site 46S323HSTTPLSSTRGTGLP
Site 47T327PLSSTRGTGLPAITD
Site 48T333GTGLPAITDVPRRIS
Site 49S340TDVPRRISDDDTATS
Site 50T344RRISDDDTATSDFCL
Site 51T346ISDDDTATSDFCLWP
Site 52S347SDDDTATSDFCLWPS
Site 53S354SDFCLWPSTLSKKSQ
Site 54T355DFCLWPSTLSKKSQA
Site 55S360PSTLSKKSQAGASEL
Site 56S371ASELGPFSDPRQFPS
Site 57S378SDPRQFPSISSLTES
Site 58S380PRQFPSISSLTESRF
Site 59S381RQFPSISSLTESRFS
Site 60T383FPSISSLTESRFSNP
Site 61S385SISSLTESRFSNPRM
Site 62S388SLTESRFSNPRMHYP
Site 63Y394FSNPRMHYPATFTYT
Site 64T397PRMHYPATFTYTPPV
Site 65Y400HYPATFTYTPPVTSG
Site 66T401YPATFTYTPPVTSGM
Site 67S406TYTPPVTSGMSLGMS
Site 68S413SGMSLGMSATTHYHT
Site 69Y418GMSATTHYHTYLPPP
Site 70T420SATTHYHTYLPPPYP
Site 71Y421ATTHYHTYLPPPYPG
Site 72Y426HTYLPPPYPGSSQSQ
Site 73S429LPPPYPGSSQSQSGP
Site 74S430PPPYPGSSQSQSGPF
Site 75S432PYPGSSQSQSGPFQT
Site 76S434PGSSQSQSGPFQTSS
Site 77S440QSGPFQTSSTPYLYY
Site 78S441SGPFQTSSTPYLYYG
Site 79T442GPFQTSSTPYLYYGT
Site 80Y444FQTSSTPYLYYGTSS
Site 81Y446TSSTPYLYYGTSSGS
Site 82Y447SSTPYLYYGTSSGSY
Site 83T449TPYLYYGTSSGSYQF
Site 84S450PYLYYGTSSGSYQFP
Site 85Y454YGTSSGSYQFPMVPG
Site 86S465MVPGGDRSPSRMLPP
Site 87S467PGGDRSPSRMLPPCT
Site 88T474SRMLPPCTTTSNGST
Site 89T475RMLPPCTTTSNGSTL
Site 90S477LPPCTTTSNGSTLLN
Site 91T481TTTSNGSTLLNPNLP
Site 92S499DGVDADGSHSSSPTV
Site 93S501VDADGSHSSSPTVLN
Site 94S502DADGSHSSSPTVLNS
Site 95S503ADGSHSSSPTVLNSS
Site 96T505GSHSSSPTVLNSSGR
Site 97S509SSPTVLNSSGRMDES
Site 98S510SPTVLNSSGRMDESV
Site 99Y521DESVWRPY_______
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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