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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Kv3.3
Full Name:
Potassium voltage-gated channel subfamily C member 3
Alias:
KCNC3; KSHIIID; Ootassium voltage-gated channel subfamily C member 3; Potassium voltage-gated channel, Shaw-related subfamily, member 3; SCA13; Shaw-related voltage-gated potassium channel protein 3; Voltage-gated potassium channel subunit Kv3.3
Type:
Mass (Da):
80578
Number AA:
757
UniProt ID:
Q14003
International Prot ID:
IPI00289965
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008076
Uniprot
OncoNet
Molecular Function:
GO:0030955
GO:0005515
GO:0005249
PhosphoSite+
KinaseNET
Biological Process:
GO:0008219
GO:0006813
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
L
S
S
V
C
V
S
S
F
Site 2
S8
M
L
S
S
V
C
V
S
S
F
R
G
R
Q
G
Site 3
S9
L
S
S
V
C
V
S
S
F
R
G
R
Q
G
A
Site 4
S30
P
P
P
Q
P
P
E
S
P
P
P
P
P
L
P
Site 5
S51
A
Q
P
G
P
A
A
S
P
A
G
P
P
A
P
Site 6
S87
H
G
G
G
G
G
D
S
G
K
I
V
I
N
V
Site 7
T101
V
G
G
V
R
H
E
T
Y
R
S
T
L
R
T
Site 8
Y102
G
G
V
R
H
E
T
Y
R
S
T
L
R
T
L
Site 9
S104
V
R
H
E
T
Y
R
S
T
L
R
T
L
P
G
Site 10
T105
R
H
E
T
Y
R
S
T
L
R
T
L
P
G
T
Site 11
T108
T
Y
R
S
T
L
R
T
L
P
G
T
R
L
A
Site 12
T112
T
L
R
T
L
P
G
T
R
L
A
G
L
T
E
Site 13
T118
G
T
R
L
A
G
L
T
E
P
E
A
A
A
R
Site 14
Y128
E
A
A
A
R
F
D
Y
D
P
G
A
D
E
F
Site 15
Y146
R
H
P
G
V
F
A
Y
V
L
N
Y
Y
R
T
Site 16
Y150
V
F
A
Y
V
L
N
Y
Y
R
T
G
K
L
H
Site 17
Y151
F
A
Y
V
L
N
Y
Y
R
T
G
K
L
H
C
Site 18
S201
D
A
E
E
A
L
D
S
F
E
A
P
D
P
A
Site 19
Y284
W
A
L
F
E
D
P
Y
S
S
R
A
A
R
Y
Site 20
S285
A
L
F
E
D
P
Y
S
S
R
A
A
R
Y
V
Site 21
S327
N
K
T
V
T
Q
A
S
P
I
P
G
A
P
P
Site 22
S379
D
K
V
E
F
L
K
S
S
L
N
I
I
D
C
Site 23
S380
K
V
E
F
L
K
S
S
L
N
I
I
D
C
V
Site 24
T440
G
L
R
V
L
G
H
T
L
R
A
S
T
N
E
Site 25
Y486
I
L
G
S
N
H
T
Y
F
K
N
I
P
I
G
Site 26
Y510
T
L
G
Y
G
D
M
Y
P
K
T
W
S
G
M
Site 27
S571
P
R
P
P
Q
P
G
S
P
N
Y
C
K
P
D
Site 28
Y574
P
Q
P
G
S
P
N
Y
C
K
P
D
P
P
P
Site 29
S591
P
P
H
P
H
H
G
S
G
G
I
S
P
P
P
Site 30
S595
H
H
G
S
G
G
I
S
P
P
P
P
I
T
P
Site 31
T601
I
S
P
P
P
P
I
T
P
P
S
M
G
V
T
Site 32
Y613
G
V
T
V
A
G
A
Y
P
A
G
P
H
T
H
Site 33
T619
A
Y
P
A
G
P
H
T
H
P
G
L
L
R
G
Site 34
S686
A
I
D
Q
P
A
M
S
P
E
D
K
S
P
I
Site 35
S691
A
M
S
P
E
D
K
S
P
I
T
P
G
S
R
Site 36
T694
P
E
D
K
S
P
I
T
P
G
S
R
G
R
Y
Site 37
S697
K
S
P
I
T
P
G
S
R
G
R
Y
S
R
D
Site 38
Y701
T
P
G
S
R
G
R
Y
S
R
D
R
A
C
F
Site 39
S702
P
G
S
R
G
R
Y
S
R
D
R
A
C
F
L
Site 40
T711
D
R
A
C
F
L
L
T
D
Y
A
P
S
P
D
Site 41
S716
L
L
T
D
Y
A
P
S
P
D
G
S
I
R
K
Site 42
S720
Y
A
P
S
P
D
G
S
I
R
K
A
T
G
A
Site 43
T725
D
G
S
I
R
K
A
T
G
A
P
P
L
P
P
Site 44
S742
W
R
K
P
G
P
P
S
F
L
P
D
L
N
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation