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Updated November 2019
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Protein Info
Short Name:
NID2
Full Name:
Nidogen-2
Alias:
Osteonidogen
Type:
Mass (Da):
151254
Number AA:
1375
UniProt ID:
Q14112
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S55
L
Q
E
G
D
D
E
S
S
A
V
V
K
L
A
Site 2
S56
Q
E
G
D
D
E
S
S
A
V
V
K
L
A
N
Site 3
Y68
L
A
N
P
L
H
F
Y
E
A
R
F
S
N
L
Site 4
T92
T
Q
D
F
P
R
E
T
Q
Y
V
D
Y
D
F
Site 5
Y94
D
F
P
R
E
T
Q
Y
V
D
Y
D
F
P
T
Site 6
Y97
R
E
T
Q
Y
V
D
Y
D
F
P
T
D
F
P
Site 7
T115
P
F
L
A
D
I
D
T
S
H
G
R
G
R
V
Site 8
S116
F
L
A
D
I
D
T
S
H
G
R
G
R
V
L
Site 9
Y124
H
G
R
G
R
V
L
Y
R
E
D
T
S
P
A
Site 10
T128
R
V
L
Y
R
E
D
T
S
P
A
V
L
G
L
Site 11
S147
V
R
A
G
F
P
R
S
A
R
F
T
P
T
H
Site 12
T151
F
P
R
S
A
R
F
T
P
T
H
A
F
L
A
Site 13
Y166
T
W
E
Q
V
G
A
Y
E
E
V
K
R
G
A
Site 14
S176
V
K
R
G
A
L
P
S
G
E
L
N
T
F
Q
Site 15
S188
T
F
Q
A
V
L
A
S
D
G
S
D
S
Y
A
Site 16
Y194
A
S
D
G
S
D
S
Y
A
L
F
L
Y
P
A
Site 17
T209
N
G
L
Q
F
L
G
T
R
P
K
E
S
Y
N
Site 18
Y215
G
T
R
P
K
E
S
Y
N
V
Q
L
Q
L
P
Site 19
S237
G
E
A
D
D
L
K
S
E
G
P
Y
F
S
L
Site 20
Y241
D
L
K
S
E
G
P
Y
F
S
L
T
S
T
E
Site 21
S243
K
S
E
G
P
Y
F
S
L
T
S
T
E
Q
S
Site 22
S246
G
P
Y
F
S
L
T
S
T
E
Q
S
V
K
N
Site 23
T247
P
Y
F
S
L
T
S
T
E
Q
S
V
K
N
L
Site 24
S250
S
L
T
S
T
E
Q
S
V
K
N
L
Y
Q
L
Site 25
Y255
E
Q
S
V
K
N
L
Y
Q
L
S
N
L
G
I
Site 26
S274
A
F
H
I
G
S
T
S
P
L
D
N
V
R
P
Site 27
S292
G
D
L
S
A
A
H
S
S
V
P
L
G
R
S
Site 28
S293
D
L
S
A
A
H
S
S
V
P
L
G
R
S
F
Site 29
S301
V
P
L
G
R
S
F
S
H
A
T
A
L
E
S
Site 30
S308
S
H
A
T
A
L
E
S
D
Y
N
E
D
N
L
Site 31
Y310
A
T
A
L
E
S
D
Y
N
E
D
N
L
D
Y
Site 32
Y317
Y
N
E
D
N
L
D
Y
Y
D
V
N
E
E
E
Site 33
Y318
N
E
D
N
L
D
Y
Y
D
V
N
E
E
E
A
Site 34
Y327
V
N
E
E
E
A
E
Y
L
P
G
E
P
E
E
Site 35
S341
E
A
L
N
G
H
S
S
I
D
V
S
F
Q
S
Site 36
S345
G
H
S
S
I
D
V
S
F
Q
S
K
V
D
T
Site 37
S348
S
I
D
V
S
F
Q
S
K
V
D
T
K
P
L
Site 38
T352
S
F
Q
S
K
V
D
T
K
P
L
E
E
S
S
Site 39
T360
K
P
L
E
E
S
S
T
L
D
P
H
T
K
E
Site 40
T365
S
S
T
L
D
P
H
T
K
E
G
T
S
L
G
Site 41
T369
D
P
H
T
K
E
G
T
S
L
G
E
V
G
G
Site 42
S370
P
H
T
K
E
G
T
S
L
G
E
V
G
G
P
Site 43
T391
E
P
W
D
E
R
E
T
R
S
P
A
P
P
E
Site 44
S393
W
D
E
R
E
T
R
S
P
A
P
P
E
V
D
Site 45
S403
P
P
E
V
D
R
D
S
L
A
P
S
W
E
T
Site 46
S407
D
R
D
S
L
A
P
S
W
E
T
P
P
P
Y
Site 47
T410
S
L
A
P
S
W
E
T
P
P
P
Y
P
E
N
Site 48
Y414
S
W
E
T
P
P
P
Y
P
E
N
G
S
I
Q
Site 49
S419
P
P
Y
P
E
N
G
S
I
Q
P
Y
P
D
G
Site 50
Y423
E
N
G
S
I
Q
P
Y
P
D
G
G
P
V
P
Site 51
S431
P
D
G
G
P
V
P
S
E
M
D
V
P
P
A
Site 52
S448
E
E
E
I
V
L
R
S
Y
P
A
S
D
H
T
Site 53
Y449
E
E
I
V
L
R
S
Y
P
A
S
D
H
T
T
Site 54
S452
V
L
R
S
Y
P
A
S
D
H
T
T
P
L
S
Site 55
T455
S
Y
P
A
S
D
H
T
T
P
L
S
R
G
T
Site 56
T456
Y
P
A
S
D
H
T
T
P
L
S
R
G
T
Y
Site 57
S459
S
D
H
T
T
P
L
S
R
G
T
Y
E
V
G
Site 58
T462
T
T
P
L
S
R
G
T
Y
E
V
G
L
E
D
Site 59
Y463
T
P
L
S
R
G
T
Y
E
V
G
L
E
D
N
Site 60
Y480
S
N
T
E
V
F
T
Y
N
A
A
N
K
E
T
Site 61
T502
C
S
R
H
A
F
C
T
D
Y
A
T
G
F
C
Site 62
Y504
R
H
A
F
C
T
D
Y
A
T
G
F
C
C
H
Site 63
T506
A
F
C
T
D
Y
A
T
G
F
C
C
H
C
Q
Site 64
T545
G
H
L
H
V
G
H
T
P
V
H
F
T
D
V
Site 65
Y557
T
D
V
D
L
H
A
Y
I
V
G
N
D
G
R
Site 66
Y566
V
G
N
D
G
R
A
Y
T
A
I
S
H
I
P
Site 67
T567
G
N
D
G
R
A
Y
T
A
I
S
H
I
P
Q
Site 68
S601
F
A
L
E
K
P
G
S
E
N
G
F
S
L
A
Site 69
T619
F
T
H
D
M
E
V
T
F
Y
P
G
E
E
T
Site 70
Y621
H
D
M
E
V
T
F
Y
P
G
E
E
T
V
R
Site 71
T626
T
F
Y
P
G
E
E
T
V
R
I
T
Q
T
A
Site 72
T630
G
E
E
T
V
R
I
T
Q
T
A
E
G
L
D
Site 73
Y641
E
G
L
D
P
E
N
Y
L
S
I
K
T
N
I
Site 74
S643
L
D
P
E
N
Y
L
S
I
K
T
N
I
Q
G
Site 75
Y654
N
I
Q
G
Q
V
P
Y
V
P
A
N
F
T
A
Site 76
T660
P
Y
V
P
A
N
F
T
A
H
I
S
P
Y
K
Site 77
S664
A
N
F
T
A
H
I
S
P
Y
K
E
L
Y
H
Site 78
Y670
I
S
P
Y
K
E
L
Y
H
Y
S
D
S
T
V
Site 79
Y672
P
Y
K
E
L
Y
H
Y
S
D
S
T
V
T
S
Site 80
S673
Y
K
E
L
Y
H
Y
S
D
S
T
V
T
S
T
Site 81
S675
E
L
Y
H
Y
S
D
S
T
V
T
S
T
S
S
Site 82
T676
L
Y
H
Y
S
D
S
T
V
T
S
T
S
S
R
Site 83
S679
Y
S
D
S
T
V
T
S
T
S
S
R
D
Y
S
Site 84
T680
S
D
S
T
V
T
S
T
S
S
R
D
Y
S
L
Site 85
S681
D
S
T
V
T
S
T
S
S
R
D
Y
S
L
T
Site 86
S682
S
T
V
T
S
T
S
S
R
D
Y
S
L
T
F
Site 87
Y685
T
S
T
S
S
R
D
Y
S
L
T
F
G
A
I
Site 88
S686
S
T
S
S
R
D
Y
S
L
T
F
G
A
I
N
Site 89
T688
S
S
R
D
Y
S
L
T
F
G
A
I
N
Q
T
Site 90
Y706
R
I
H
Q
N
I
T
Y
Q
V
C
R
H
A
P
Site 91
S717
R
H
A
P
R
H
P
S
F
P
T
T
Q
Q
L
Site 92
T721
R
H
P
S
F
P
T
T
Q
Q
L
N
V
D
R
Site 93
Y733
V
D
R
V
F
A
L
Y
N
D
E
E
R
V
L
Site 94
S755
I
G
P
V
K
E
D
S
D
P
T
P
V
N
P
Site 95
T758
V
K
E
D
S
D
P
T
P
V
N
P
C
Y
D
Site 96
T773
G
S
H
M
C
D
T
T
A
R
C
H
P
G
T
Site 97
T780
T
A
R
C
H
P
G
T
G
V
D
Y
T
C
E
Site 98
Y784
H
P
G
T
G
V
D
Y
T
C
E
C
A
S
G
Site 99
T785
P
G
T
G
V
D
Y
T
C
E
C
A
S
G
Y
Site 100
Y792
T
C
E
C
A
S
G
Y
Q
G
D
G
R
N
C
Site 101
S816
F
H
R
C
G
P
N
S
V
C
I
N
L
P
G
Site 102
Y833
R
C
E
C
R
S
G
Y
E
F
A
D
D
R
H
Site 103
T841
E
F
A
D
D
R
H
T
C
I
L
I
T
P
P
Site 104
T846
R
H
T
C
I
L
I
T
P
P
A
N
P
C
E
Site 105
S856
A
N
P
C
E
D
G
S
H
T
C
A
P
A
G
Site 106
T858
P
C
E
D
G
S
H
T
C
A
P
A
G
Q
A
Site 107
Y883
S
C
A
C
L
P
G
Y
A
G
D
G
H
Q
C
Site 108
T891
A
G
D
G
H
Q
C
T
D
V
D
E
C
S
E
Site 109
Y908
C
H
P
A
A
T
C
Y
N
T
P
G
S
F
S
Site 110
T910
P
A
A
T
C
Y
N
T
P
G
S
F
S
C
R
Site 111
S933
G
F
Q
C
I
P
D
S
T
S
S
L
T
P
C
Site 112
T934
F
Q
C
I
P
D
S
T
S
S
L
T
P
C
E
Site 113
S935
Q
C
I
P
D
S
T
S
S
L
T
P
C
E
Q
Site 114
S936
C
I
P
D
S
T
S
S
L
T
P
C
E
Q
Q
Site 115
T938
P
D
S
T
S
S
L
T
P
C
E
Q
Q
Q
R
Site 116
Y951
Q
R
H
A
Q
A
Q
Y
A
Y
P
G
A
R
F
Site 117
Y953
H
A
Q
A
Q
Y
A
Y
P
G
A
R
F
H
I
Site 118
T994
D
G
H
E
V
P
G
T
Q
T
P
P
G
S
T
Site 119
T996
H
E
V
P
G
T
Q
T
P
P
G
S
T
P
P
Site 120
S1000
G
T
Q
T
P
P
G
S
T
P
P
H
C
G
P
Site 121
T1001
T
Q
T
P
P
G
S
T
P
P
H
C
G
P
S
Site 122
S1008
T
P
P
H
C
G
P
S
P
E
P
T
Q
R
P
Site 123
T1012
C
G
P
S
P
E
P
T
Q
R
P
P
T
I
C
Site 124
T1017
E
P
T
Q
R
P
P
T
I
C
E
R
W
R
E
Site 125
T1033
L
L
E
H
Y
G
G
T
P
R
D
D
Q
Y
V
Site 126
Y1039
G
T
P
R
D
D
Q
Y
V
P
Q
C
D
D
L
Site 127
T1074
D
G
R
E
V
Q
G
T
R
S
Q
P
G
T
T
Site 128
S1076
R
E
V
Q
G
T
R
S
Q
P
G
T
T
P
A
Site 129
T1080
G
T
R
S
Q
P
G
T
T
P
A
C
I
P
T
Site 130
T1081
T
R
S
Q
P
G
T
T
P
A
C
I
P
T
V
Site 131
T1096
A
P
P
M
V
R
P
T
P
R
P
D
V
T
P
Site 132
T1102
P
T
P
R
P
D
V
T
P
P
S
V
G
T
F
Site 133
Y1120
T
Q
G
Q
Q
I
G
Y
L
P
L
N
G
T
R
Site 134
Y1157
D
C
R
E
R
M
V
Y
W
T
D
V
A
G
R
Site 135
S1167
D
V
A
G
R
T
I
S
R
A
G
L
E
L
G
Site 136
S1183
E
P
E
T
I
V
N
S
G
L
I
S
P
E
G
Site 137
Y1201
D
H
I
R
R
T
M
Y
W
T
D
S
V
L
D
Site 138
T1203
I
R
R
T
M
Y
W
T
D
S
V
L
D
K
I
Site 139
S1205
R
T
M
Y
W
T
D
S
V
L
D
K
I
E
S
Site 140
S1218
E
S
A
L
L
D
G
S
E
R
K
V
L
F
Y
Site 141
Y1225
S
E
R
K
V
L
F
Y
T
D
L
V
N
P
R
Site 142
T1226
E
R
K
V
L
F
Y
T
D
L
V
N
P
R
A
Site 143
Y1244
D
P
I
R
G
N
L
Y
W
T
D
W
N
R
E
Site 144
S1259
A
P
K
I
E
T
S
S
L
D
G
E
N
R
R
Site 145
T1271
N
R
R
I
L
I
N
T
D
I
G
L
P
N
G
Site 146
T1301
G
T
K
K
L
E
C
T
L
P
D
G
T
G
R
Site 147
T1306
E
C
T
L
P
D
G
T
G
R
R
V
I
Q
N
Site 148
S1320
N
N
L
K
Y
P
F
S
I
V
S
Y
A
D
H
Site 149
Y1324
Y
P
F
S
I
V
S
Y
A
D
H
F
Y
H
T
Site 150
Y1329
V
S
Y
A
D
H
F
Y
H
T
D
W
R
R
D
Site 151
T1331
Y
A
D
H
F
Y
H
T
D
W
R
R
D
G
V
Site 152
S1340
W
R
R
D
G
V
V
S
V
N
K
H
S
G
Q
Site 153
T1349
N
K
H
S
G
Q
F
T
D
E
Y
L
P
E
Q
Site 154
Y1352
S
G
Q
F
T
D
E
Y
L
P
E
Q
R
S
H
Site 155
Y1369
G
I
T
A
V
Y
P
Y
C
P
T
G
R
K
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation