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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
UBE4A
Full Name:
Ubiquitin conjugation factor E4 A
Alias:
E4; UBOX2; UFD2
Type:
Ubiquitin conjugating system
Mass (Da):
122561
Number AA:
1066
UniProt ID:
Q14139
International Prot ID:
IPI00556075
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000151
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0034450
PhosphoSite+
KinaseNET
Biological Process:
GO:0016567
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S46
Q
S
D
E
L
P
A
S
P
D
D
S
D
N
S
Site 2
S50
L
P
A
S
P
D
D
S
D
N
S
V
S
E
S
Site 3
S53
S
P
D
D
S
D
N
S
V
S
E
S
L
D
E
Site 4
S57
S
D
N
S
V
S
E
S
L
D
E
F
D
Y
S
Site 5
Y63
E
S
L
D
E
F
D
Y
S
V
A
E
I
S
R
Site 6
S64
S
L
D
E
F
D
Y
S
V
A
E
I
S
R
S
Site 7
S71
S
V
A
E
I
S
R
S
F
R
S
Q
Q
E
I
Site 8
S74
E
I
S
R
S
F
R
S
Q
Q
E
I
C
E
Q
Site 9
T95
I
Q
R
I
F
L
I
T
L
D
N
S
D
P
S
Site 10
S99
F
L
I
T
L
D
N
S
D
P
S
L
K
S
G
Site 11
S102
T
L
D
N
S
D
P
S
L
K
S
G
N
G
I
Site 12
S105
N
S
D
P
S
L
K
S
G
N
G
I
P
S
R
Site 13
S111
K
S
G
N
G
I
P
S
R
C
V
Y
L
E
E
Site 14
S156
N
H
L
I
N
M
T
S
S
T
T
L
N
L
S
Site 15
S163
S
S
T
T
L
N
L
S
A
D
R
D
A
G
E
Site 16
Y178
R
H
I
F
C
Y
L
Y
S
C
F
Q
R
A
K
Site 17
T206
A
V
Q
C
R
N
L
T
V
S
N
T
R
T
V
Site 18
S208
Q
C
R
N
L
T
V
S
N
T
R
T
V
L
L
Site 19
T210
R
N
L
T
V
S
N
T
R
T
V
L
L
T
P
Site 20
T216
N
T
R
T
V
L
L
T
P
E
I
Y
V
D
Q
Site 21
Y299
A
Y
L
D
I
L
L
Y
F
T
R
Q
K
D
M
Site 22
Y313
M
A
K
V
F
V
E
Y
I
Q
P
K
D
P
T
Site 23
Y325
D
P
T
N
G
Q
M
Y
Q
K
T
L
L
G
V
Site 24
Y351
G
V
V
E
N
H
G
Y
F
L
N
P
S
R
S
Site 25
S356
H
G
Y
F
L
N
P
S
R
S
S
P
Q
E
I
Site 26
S358
Y
F
L
N
P
S
R
S
S
P
Q
E
I
K
V
Site 27
S359
F
L
N
P
S
R
S
S
P
Q
E
I
K
V
Q
Site 28
S392
L
K
N
L
L
Q
L
S
P
E
T
K
H
C
I
Site 29
S454
Q
P
F
C
K
P
R
S
S
R
L
L
T
F
N
Site 30
S455
P
F
C
K
P
R
S
S
R
L
L
T
F
N
P
Site 31
T459
P
R
S
S
R
L
L
T
F
N
P
T
Y
C
A
Site 32
Y464
L
L
T
F
N
P
T
Y
C
A
L
K
E
L
N
Site 33
Y504
E
P
K
F
P
Q
N
Y
N
L
V
T
E
N
L
Site 34
S549
A
W
R
D
A
Q
Q
S
S
S
P
A
A
D
N
Site 35
S551
R
D
A
Q
Q
S
S
S
P
A
A
D
N
L
R
Site 36
T566
E
Q
F
E
R
L
M
T
I
Y
L
S
T
K
T
Site 37
T611
G
S
Q
P
I
E
L
T
F
P
L
P
D
G
Y
Site 38
S619
F
P
L
P
D
G
Y
S
S
L
A
Y
V
P
E
Site 39
S620
P
L
P
D
G
Y
S
S
L
A
Y
V
P
E
F
Site 40
Y623
D
G
Y
S
S
L
A
Y
V
P
E
F
F
A
D
Site 41
S650
A
D
D
I
L
E
T
S
A
D
S
L
E
H
V
Site 42
T694
V
M
P
H
L
D
Q
T
P
N
P
L
V
S
S
Site 43
S701
T
P
N
P
L
V
S
S
V
F
H
R
K
R
V
Site 44
Y744
Q
F
E
Q
K
F
N
Y
R
R
P
M
Y
P
I
Site 45
Y749
F
N
Y
R
R
P
M
Y
P
I
L
R
Y
M
W
Site 46
Y761
Y
M
W
G
T
D
T
Y
R
E
S
I
K
D
L
Site 47
S764
G
T
D
T
Y
R
E
S
I
K
D
L
A
D
Y
Site 48
Y771
S
I
K
D
L
A
D
Y
A
S
K
N
L
E
A
Site 49
S773
K
D
L
A
D
Y
A
S
K
N
L
E
A
M
N
Site 50
S823
K
D
R
G
E
W
D
S
L
T
P
E
A
R
R
Site 51
T825
R
G
E
W
D
S
L
T
P
E
A
R
R
E
K
Site 52
S938
T
V
P
K
D
G
R
S
Y
S
P
T
L
F
A
Site 53
Y939
V
P
K
D
G
R
S
Y
S
P
T
L
F
A
Q
Site 54
S940
P
K
D
G
R
S
Y
S
P
T
L
F
A
Q
T
Site 55
T942
D
G
R
S
Y
S
P
T
L
F
A
Q
T
V
R
Site 56
S973
N
L
A
E
R
I
K
S
L
A
D
L
Q
Q
Q
Site 57
Y985
Q
Q
Q
E
E
E
T
Y
A
D
A
C
D
E
F
Site 58
S1009
C
D
P
V
V
L
P
S
S
R
V
T
V
D
R
Site 59
S1010
D
P
V
V
L
P
S
S
R
V
T
V
D
R
S
Site 60
S1017
S
R
V
T
V
D
R
S
T
I
A
R
H
L
L
Site 61
T1018
R
V
T
V
D
R
S
T
I
A
R
H
L
L
S
Site 62
T1028
R
H
L
L
S
D
Q
T
D
P
F
N
R
S
P
Site 63
S1034
Q
T
D
P
F
N
R
S
P
L
T
M
D
Q
I
Site 64
T1037
P
F
N
R
S
P
L
T
M
D
Q
I
R
P
N
Site 65
T1045
M
D
Q
I
R
P
N
T
E
L
K
E
K
I
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation