KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
EIF3A
Full Name:
Eukaryotic translation initiation factor 3 subunit A
Alias:
EIF3; EIF3-p170; EIF3S10; EIF3-theta; Eukaryotic translation initiation factor 3 subunit 10; Eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa; Eukaryotic translation initiation factor 3, subunit A; IF3A; KIAA0139; P167; TIF32
Type:
Translation
Mass (Da):
166569
Number AA:
1382
UniProt ID:
Q14152
International Prot ID:
IPI00029012
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005852
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005198
GO:0003743
PhosphoSite+
KinaseNET
Biological Process:
GO:0001732
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y4
_
_
_
_
M
P
A
Y
F
Q
R
P
E
N
A
Site 2
Y32
Q
P
A
L
D
V
L
Y
D
V
M
K
S
K
K
Site 3
S64
L
C
V
D
L
R
K
S
H
L
A
K
E
G
L
Site 4
Y72
H
L
A
K
E
G
L
Y
Q
Y
K
N
I
C
Q
Site 5
Y74
A
K
E
G
L
Y
Q
Y
K
N
I
C
Q
Q
V
Site 6
S85
C
Q
Q
V
N
I
K
S
L
E
D
V
V
R
A
Site 7
Y93
L
E
D
V
V
R
A
Y
L
K
M
A
E
E
K
Site 8
T123
E
D
L
D
N
I
Q
T
P
E
S
V
L
L
S
Site 9
S130
T
P
E
S
V
L
L
S
A
V
S
G
E
D
T
Site 10
S133
S
V
L
L
S
A
V
S
G
E
D
T
Q
D
R
Site 11
T137
S
A
V
S
G
E
D
T
Q
D
R
T
D
R
L
Site 12
T141
G
E
D
T
Q
D
R
T
D
R
L
L
L
T
P
Site 13
S168
L
D
L
L
R
N
N
S
R
V
E
R
L
Y
H
Site 14
Y174
N
S
R
V
E
R
L
Y
H
D
I
A
Q
Q
A
Site 15
Y188
A
F
K
F
C
L
Q
Y
T
R
K
A
E
F
R
Site 16
S225
I
N
L
N
N
P
E
S
Q
S
M
H
L
E
T
Site 17
S261
E
D
I
H
G
L
F
S
L
S
K
K
P
P
K
Site 18
S263
I
H
G
L
F
S
L
S
K
K
P
P
K
P
Q
Site 19
Y275
K
P
Q
L
M
A
N
Y
Y
N
K
V
S
T
V
Site 20
Y276
P
Q
L
M
A
N
Y
Y
N
K
V
S
T
V
F
Site 21
T295
N
A
L
F
H
A
S
T
L
H
R
L
Y
H
L
Site 22
Y300
A
S
T
L
H
R
L
Y
H
L
S
R
E
M
R
Site 23
S303
L
H
R
L
Y
H
L
S
R
E
M
R
K
N
L
Site 24
T311
R
E
M
R
K
N
L
T
Q
D
E
M
Q
R
M
Site 25
S319
Q
D
E
M
Q
R
M
S
T
R
V
L
L
A
T
Site 26
T320
D
E
M
Q
R
M
S
T
R
V
L
L
A
T
L
Site 27
T332
A
T
L
S
I
P
I
T
P
E
R
T
D
I
A
Site 28
T336
I
P
I
T
P
E
R
T
D
I
A
R
L
L
D
Site 29
T357
E
K
Q
R
R
L
A
T
L
L
G
L
Q
A
P
Site 30
Y382
V
R
F
N
V
L
Q
Y
V
V
P
E
V
K
D
Site 31
Y391
V
P
E
V
K
D
L
Y
N
W
L
E
V
E
F
Site 32
Y427
K
E
P
E
L
Q
Q
Y
V
P
Q
L
Q
N
N
Site 33
S444
L
R
L
L
Q
Q
V
S
Q
I
Y
Q
S
I
E
Site 34
Y447
L
Q
Q
V
S
Q
I
Y
Q
S
I
E
F
S
R
Site 35
S449
Q
V
S
Q
I
Y
Q
S
I
E
F
S
R
L
T
Site 36
T487
L
Q
V
R
I
D
H
T
S
R
T
L
S
F
G
Site 37
S488
Q
V
R
I
D
H
T
S
R
T
L
S
F
G
S
Site 38
T490
R
I
D
H
T
S
R
T
L
S
F
G
S
D
L
Site 39
S492
D
H
T
S
R
T
L
S
F
G
S
D
L
N
Y
Site 40
Y499
S
F
G
S
D
L
N
Y
A
T
R
E
D
A
P
Site 41
S513
P
I
G
P
H
L
Q
S
M
P
S
E
Q
I
R
Site 42
S516
P
H
L
Q
S
M
P
S
E
Q
I
R
N
Q
L
Site 43
T524
E
Q
I
R
N
Q
L
T
A
M
S
S
V
L
A
Site 44
Y557
H
Q
L
A
V
T
A
Y
L
K
N
S
R
K
E
Site 45
T574
R
I
L
A
R
R
Q
T
I
E
E
R
K
E
R
Site 46
S584
E
R
K
E
R
L
E
S
L
N
I
Q
R
E
K
Site 47
T635
H
E
Q
I
K
K
K
T
V
R
E
R
L
E
Q
Site 48
Y697
N
Q
E
K
K
I
D
Y
F
E
R
A
K
R
L
Site 49
S712
E
E
I
P
L
I
K
S
A
Y
E
E
Q
R
I
Site 50
Y714
I
P
L
I
K
S
A
Y
E
E
Q
R
I
K
D
Site 51
T734
Q
Q
E
E
E
R
I
T
T
M
Q
L
E
R
E
Site 52
T735
Q
E
E
E
R
I
T
T
M
Q
L
E
R
E
K
Site 53
S751
L
E
H
K
N
R
M
S
R
M
L
E
D
R
D
Site 54
S770
R
L
K
A
A
R
Q
S
V
Y
E
E
K
L
K
Site 55
T805
R
K
E
E
R
R
I
T
Y
Y
R
E
K
E
E
Site 56
Y806
K
E
E
R
R
I
T
Y
Y
R
E
K
E
E
E
Site 57
Y807
E
E
R
R
I
T
Y
Y
R
E
K
E
E
E
E
Site 58
Y844
R
E
E
E
L
R
E
Y
Q
E
R
V
K
K
L
Site 59
S881
E
E
R
R
L
G
D
S
S
L
S
R
K
D
S
Site 60
S882
E
R
R
L
G
D
S
S
L
S
R
K
D
S
R
Site 61
S884
R
L
G
D
S
S
L
S
R
K
D
S
R
W
G
Site 62
S888
S
S
L
S
R
K
D
S
R
W
G
D
R
D
S
Site 63
S895
S
R
W
G
D
R
D
S
E
G
T
W
R
K
G
Site 64
T898
G
D
R
D
S
E
G
T
W
R
K
G
P
E
A
Site 65
S907
R
K
G
P
E
A
D
S
E
W
R
R
G
P
P
Site 66
S929
E
G
R
D
E
D
R
S
H
R
R
D
E
E
R
Site 67
S949
D
D
E
D
R
E
P
S
L
R
P
D
D
D
R
Site 68
S978
G
P
E
E
D
R
F
S
R
R
G
A
D
D
D
Site 69
S988
G
A
D
D
D
R
P
S
W
R
N
T
D
D
D
Site 70
T992
D
R
P
S
W
R
N
T
D
D
D
R
P
P
R
Site 71
S1028
G
L
D
E
D
R
G
S
W
R
T
A
D
E
D
Site 72
S1058
G
G
A
D
D
E
R
S
S
W
R
N
A
D
D
Site 73
S1059
G
A
D
D
E
R
S
S
W
R
N
A
D
D
D
Site 74
S1149
N
M
D
D
D
R
L
S
R
R
A
D
D
D
R
Site 75
S1164
F
P
R
R
G
D
D
S
R
P
G
P
W
R
P
Site 76
S1188
K
E
K
A
R
E
E
S
W
G
P
P
R
E
S
Site 77
S1195
S
W
G
P
P
R
E
S
R
P
S
E
E
R
E
Site 78
S1198
P
P
R
E
S
R
P
S
E
E
R
E
W
D
R
Site 79
S1256
R
R
G
P
A
E
E
S
S
S
W
R
D
S
S
Site 80
S1257
R
G
P
A
E
E
S
S
S
W
R
D
S
S
R
Site 81
S1258
G
P
A
E
E
S
S
S
W
R
D
S
S
R
R
Site 82
S1262
E
S
S
S
W
R
D
S
S
R
R
D
D
R
D
Site 83
S1263
S
S
S
W
R
D
S
S
R
R
D
D
R
D
R
Site 84
S1302
R
R
G
P
P
L
R
S
E
R
E
E
V
S
S
Site 85
S1309
S
E
R
E
E
V
S
S
W
R
R
A
D
D
R
Site 86
S1336
R
V
P
P
P
A
L
S
R
D
R
E
R
D
R
Site 87
S1355
E
G
E
K
E
K
A
S
W
R
A
E
K
D
R
Site 88
S1364
R
A
E
K
D
R
E
S
L
R
R
T
K
N
E
Site 89
T1368
D
R
E
S
L
R
R
T
K
N
E
T
D
E
D
Site 90
T1372
L
R
R
T
K
N
E
T
D
E
D
G
W
T
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation