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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GIT2
Full Name:
ARF GTPase-activating protein GIT2
Alias:
G protein-coupled receptor kinase interacting ArfGAP 2; G protein-coupled receptor kinase- interactor 2; G protein-coupled receptor kinase-interactor 2; KIAA0148; Tyrosine-phosphorylated protein CAT-2
Type:
GTPase-activating protein for G protein
Mass (Da):
84543
Number AA:
759
UniProt ID:
Q14161
International Prot ID:
IPI00238218
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0008060
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0032312
GO:0008277
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
S
K
R
L
R
S
S
E
V
C
A
D
C
Site 2
S8
M
S
K
R
L
R
S
S
E
V
C
A
D
C
S
Site 3
S15
S
E
V
C
A
D
C
S
G
P
D
P
S
W
A
Site 4
S20
D
C
S
G
P
D
P
S
W
A
S
V
N
R
G
Site 5
S23
G
P
D
P
S
W
A
S
V
N
R
G
T
F
L
Site 6
S40
E
C
C
S
V
H
R
S
L
G
R
H
I
S
Q
Site 7
S46
R
S
L
G
R
H
I
S
Q
V
R
H
L
K
H
Site 8
T54
Q
V
R
H
L
K
H
T
P
W
P
P
T
L
L
Site 9
Y68
L
Q
M
V
E
T
L
Y
N
N
G
A
N
S
I
Site 10
S79
A
N
S
I
W
E
H
S
L
L
D
P
A
S
I
Site 11
S85
H
S
L
L
D
P
A
S
I
M
S
G
R
R
K
Site 12
S88
L
D
P
A
S
I
M
S
G
R
R
K
A
N
P
Site 13
S127
L
P
C
R
D
D
D
S
V
T
A
K
D
L
S
Site 14
T129
C
R
D
D
D
S
V
T
A
K
D
L
S
K
Q
Site 15
S134
S
V
T
A
K
D
L
S
K
Q
L
H
S
S
V
Site 16
S139
D
L
S
K
Q
L
H
S
S
V
R
T
G
N
L
Site 17
S140
L
S
K
Q
L
H
S
S
V
R
T
G
N
L
E
Site 18
T169
F
H
P
E
K
G
N
T
P
L
H
V
A
S
K
Site 19
Y189
Q
A
E
L
L
A
V
Y
G
A
D
P
G
T
Q
Site 20
T195
V
Y
G
A
D
P
G
T
Q
D
S
S
G
K
T
Site 21
S198
A
D
P
G
T
Q
D
S
S
G
K
T
P
V
D
Site 22
S199
D
P
G
T
Q
D
S
S
G
K
T
P
V
D
Y
Site 23
T202
T
Q
D
S
S
G
K
T
P
V
D
Y
A
R
Q
Site 24
Y206
S
G
K
T
P
V
D
Y
A
R
Q
G
G
H
H
Site 25
Y233
L
T
D
R
L
A
F
Y
L
C
G
R
K
P
D
Site 26
S260
A
D
S
S
L
D
L
S
E
L
A
K
A
A
K
Site 27
S272
A
A
K
K
K
L
Q
S
L
S
N
H
L
F
E
Site 28
S274
K
K
K
L
Q
S
L
S
N
H
L
F
E
E
L
Site 29
Y286
E
E
L
A
M
D
V
Y
D
E
V
D
R
R
E
Site 30
T294
D
E
V
D
R
R
E
T
D
A
V
W
L
A
T
Site 31
Y323
F
L
P
V
N
P
E
Y
S
S
T
R
N
Q
G
Site 32
S325
P
V
N
P
E
Y
S
S
T
R
N
Q
G
R
Q
Site 33
T326
V
N
P
E
Y
S
S
T
R
N
Q
G
R
Q
K
Site 34
T344
F
N
A
H
E
F
A
T
L
V
I
D
I
L
S
Site 35
S351
T
L
V
I
D
I
L
S
D
A
K
R
R
Q
Q
Site 36
S360
A
K
R
R
Q
Q
G
S
S
L
S
G
S
K
D
Site 37
S361
K
R
R
Q
Q
G
S
S
L
S
G
S
K
D
N
Site 38
S363
R
Q
Q
G
S
S
L
S
G
S
K
D
N
V
E
Site 39
S365
Q
G
S
S
L
S
G
S
K
D
N
V
E
L
I
Site 40
S381
K
T
I
N
N
Q
H
S
V
E
S
Q
D
N
D
Site 41
Y392
Q
D
N
D
Q
P
D
Y
D
S
V
A
S
D
E
Site 42
S394
N
D
Q
P
D
Y
D
S
V
A
S
D
E
D
T
Site 43
S397
P
D
Y
D
S
V
A
S
D
E
D
T
D
L
E
Site 44
T401
S
V
A
S
D
E
D
T
D
L
E
T
T
A
S
Site 45
T405
D
E
D
T
D
L
E
T
T
A
S
K
T
N
R
Site 46
T406
E
D
T
D
L
E
T
T
A
S
K
T
N
R
Q
Site 47
S408
T
D
L
E
T
T
A
S
K
T
N
R
Q
K
S
Site 48
T410
L
E
T
T
A
S
K
T
N
R
Q
K
S
L
D
Site 49
S415
S
K
T
N
R
Q
K
S
L
D
S
D
L
S
D
Site 50
S418
N
R
Q
K
S
L
D
S
D
L
S
D
G
P
V
Site 51
S421
K
S
L
D
S
D
L
S
D
G
P
V
T
V
Q
Site 52
T426
D
L
S
D
G
P
V
T
V
Q
E
F
M
E
V
Site 53
S455
M
K
V
N
N
N
L
S
D
E
L
R
I
M
Q
Site 54
S470
K
K
L
Q
T
L
Q
S
E
N
S
N
L
R
K
Site 55
S473
Q
T
L
Q
S
E
N
S
N
L
R
K
Q
A
T
Site 56
T480
S
N
L
R
K
Q
A
T
T
N
V
Y
Q
V
Q
Site 57
T481
N
L
R
K
Q
A
T
T
N
V
Y
Q
V
Q
T
Site 58
Y484
K
Q
A
T
T
N
V
Y
Q
V
Q
T
G
S
E
Site 59
T488
T
N
V
Y
Q
V
Q
T
G
S
E
Y
T
D
T
Site 60
S490
V
Y
Q
V
Q
T
G
S
E
Y
T
D
T
S
N
Site 61
Y492
Q
V
Q
T
G
S
E
Y
T
D
T
S
N
H
S
Site 62
T493
V
Q
T
G
S
E
Y
T
D
T
S
N
H
S
S
Site 63
T495
T
G
S
E
Y
T
D
T
S
N
H
S
S
L
K
Site 64
S496
G
S
E
Y
T
D
T
S
N
H
S
S
L
K
R
Site 65
S499
Y
T
D
T
S
N
H
S
S
L
K
R
R
P
S
Site 66
S500
T
D
T
S
N
H
S
S
L
K
R
R
P
S
A
Site 67
S506
S
S
L
K
R
R
P
S
A
R
G
S
R
P
M
Site 68
S510
R
R
P
S
A
R
G
S
R
P
M
S
M
Y
E
Site 69
S514
A
R
G
S
R
P
M
S
M
Y
E
T
G
S
G
Site 70
Y516
G
S
R
P
M
S
M
Y
E
T
G
S
G
Q
K
Site 71
T518
R
P
M
S
M
Y
E
T
G
S
G
Q
K
P
Y
Site 72
Y525
T
G
S
G
Q
K
P
Y
L
P
M
G
E
A
S
Site 73
S532
Y
L
P
M
G
E
A
S
R
P
E
E
S
R
M
Site 74
S537
E
A
S
R
P
E
E
S
R
M
R
L
Q
P
F
Site 75
S556
G
R
S
A
L
V
T
S
S
S
S
L
P
S
F
Site 76
S557
R
S
A
L
V
T
S
S
S
S
L
P
S
F
P
Site 77
S558
S
A
L
V
T
S
S
S
S
L
P
S
F
P
S
Site 78
S559
A
L
V
T
S
S
S
S
L
P
S
F
P
S
T
Site 79
S562
T
S
S
S
S
L
P
S
F
P
S
T
L
S
W
Site 80
S565
S
S
L
P
S
F
P
S
T
L
S
W
S
R
D
Site 81
T566
S
L
P
S
F
P
S
T
L
S
W
S
R
D
E
Site 82
S568
P
S
F
P
S
T
L
S
W
S
R
D
E
S
A
Site 83
S570
F
P
S
T
L
S
W
S
R
D
E
S
A
R
R
Site 84
S574
L
S
W
S
R
D
E
S
A
R
R
A
S
R
L
Site 85
S579
D
E
S
A
R
R
A
S
R
L
E
K
Q
N
S
Site 86
S586
S
R
L
E
K
Q
N
S
T
P
E
S
D
Y
D
Site 87
T587
R
L
E
K
Q
N
S
T
P
E
S
D
Y
D
N
Site 88
S590
K
Q
N
S
T
P
E
S
D
Y
D
N
T
P
N
Site 89
Y592
N
S
T
P
E
S
D
Y
D
N
T
P
N
D
M
Site 90
T595
P
E
S
D
Y
D
N
T
P
N
D
M
E
P
D
Site 91
S606
M
E
P
D
G
M
G
S
S
R
K
G
R
Q
R
Site 92
S607
E
P
D
G
M
G
S
S
R
K
G
R
Q
R
S
Site 93
S614
S
R
K
G
R
Q
R
S
M
V
W
P
G
D
G
Site 94
T626
G
D
G
L
V
P
D
T
A
E
P
H
V
A
P
Site 95
S634
A
E
P
H
V
A
P
S
P
T
L
P
S
T
E
Site 96
T636
P
H
V
A
P
S
P
T
L
P
S
T
E
D
V
Site 97
S639
A
P
S
P
T
L
P
S
T
E
D
V
I
R
K
Site 98
T640
P
S
P
T
L
P
S
T
E
D
V
I
R
K
T
Site 99
T647
T
E
D
V
I
R
K
T
E
Q
I
T
K
N
I
Site 100
S668
A
Q
E
N
K
H
D
S
Y
I
P
C
S
E
R
Site 101
Y669
Q
E
N
K
H
D
S
Y
I
P
C
S
E
R
I
Site 102
S673
H
D
S
Y
I
P
C
S
E
R
I
H
V
A
V
Site 103
S693
L
F
P
K
K
P
K
S
D
M
V
R
T
S
L
Site 104
T698
P
K
S
D
M
V
R
T
S
L
R
L
L
T
S
Site 105
S699
K
S
D
M
V
R
T
S
L
R
L
L
T
S
S
Site 106
T704
R
T
S
L
R
L
L
T
S
S
A
Y
R
L
Q
Site 107
S705
T
S
L
R
L
L
T
S
S
A
Y
R
L
Q
S
Site 108
S706
S
L
R
L
L
T
S
S
A
Y
R
L
Q
S
E
Site 109
Y708
R
L
L
T
S
S
A
Y
R
L
Q
S
E
C
K
Site 110
S712
S
S
A
Y
R
L
Q
S
E
C
K
K
T
L
P
Site 111
T717
L
Q
S
E
C
K
K
T
L
P
G
D
P
G
S
Site 112
S724
T
L
P
G
D
P
G
S
P
T
D
V
Q
L
V
Site 113
T726
P
G
D
P
G
S
P
T
D
V
Q
L
V
T
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation