KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
DOC2A
Full Name:
Double C2-like domain-containing protein alpha
Alias:
Double C2-like domains, alpha
Type:
Membrane, Synapse, Cytoplasmic vesicle, Synaptosome, Cell junction, Synaptic vesicle protein
Mass (Da):
43959
Number AA:
400
UniProt ID:
Q14183
International Prot ID:
IPI00455076
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0019898
GO:0005764
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005544
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007399
GO:0017158
GO:0007268
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S33
I
R
P
I
R
Q
I
S
D
Y
F
P
R
G
P
Site 2
Y35
P
I
R
Q
I
S
D
Y
F
P
R
G
P
G
P
Site 3
Y82
D
G
A
E
V
D
S
Y
D
S
D
D
A
T
A
Site 4
S84
A
E
V
D
S
Y
D
S
D
D
A
T
A
L
G
Site 5
T88
S
Y
D
S
D
D
A
T
A
L
G
T
L
E
F
Site 6
T147
A
N
K
L
K
T
K
T
Q
R
N
T
L
N
P
Site 7
T151
K
T
K
T
Q
R
N
T
L
N
P
V
W
N
E
Site 8
T161
P
V
W
N
E
D
L
T
Y
S
G
I
T
D
D
Site 9
Y162
V
W
N
E
D
L
T
Y
S
G
I
T
D
D
D
Site 10
T171
G
I
T
D
D
D
I
T
H
K
V
L
R
I
A
Site 11
S186
V
C
D
E
D
K
L
S
H
N
E
F
I
G
E
Site 12
S204
P
L
R
R
L
K
P
S
Q
K
K
H
F
N
I
Site 13
S221
E
R
Q
V
P
L
A
S
P
S
S
M
S
A
A
Site 14
Y235
A
L
R
G
I
S
C
Y
L
K
E
L
E
Q
A
Site 15
S258
E
R
G
R
I
L
L
S
L
S
Y
S
S
R
R
Site 16
S260
G
R
I
L
L
S
L
S
Y
S
S
R
R
R
G
Site 17
Y261
R
I
L
L
S
L
S
Y
S
S
R
R
R
G
L
Site 18
Y286
A
A
M
D
V
N
G
Y
S
D
P
Y
V
K
T
Site 19
Y290
V
N
G
Y
S
D
P
Y
V
K
T
Y
L
R
P
Site 20
T293
Y
S
D
P
Y
V
K
T
Y
L
R
P
D
V
D
Site 21
Y294
S
D
P
Y
V
K
T
Y
L
R
P
D
V
D
K
Site 22
S303
R
P
D
V
D
K
K
S
K
H
K
T
C
V
K
Site 23
T307
D
K
K
S
K
H
K
T
C
V
K
K
K
T
L
Site 24
T313
K
T
C
V
K
K
K
T
L
N
P
E
F
N
E
Site 25
Y324
E
F
N
E
E
F
F
Y
E
I
E
L
S
T
L
Site 26
S329
F
F
Y
E
I
E
L
S
T
L
A
T
K
T
L
Site 27
T333
I
E
L
S
T
L
A
T
K
T
L
E
V
T
V
Site 28
T339
A
T
K
T
L
E
V
T
V
W
D
Y
D
I
G
Site 29
Y343
L
E
V
T
V
W
D
Y
D
I
G
K
S
N
D
Site 30
S356
N
D
F
I
G
G
V
S
L
G
P
G
A
R
G
Site 31
S370
G
E
A
R
K
H
W
S
D
C
L
Q
Q
P
D
Site 32
T385
A
A
L
E
R
W
H
T
L
T
S
E
L
P
P
Site 33
T387
L
E
R
W
H
T
L
T
S
E
L
P
P
A
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation